Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ghazi Atassi"'
Autor:
Rohit Duggal, Jason Isaacson, Heyue Zhou, James T. Patterson, Yanwen Fu, Tong Zhu, Gunnar F. Kaufmann, Ghazi Atassi, Lisa Kerwin, Damien Bresson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5490-5495
Bioconjugate formats provide alternative strategies for antigen targeting with bispecific antibodies. Here, PSMA-targeted Fab conjugates were generated using different bispecific formats. Interchain disulfide bridging of an αCD3 Fab enabled installa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8c4906ce0bafb63d6fafbe888c3519
https://doi.org/10.1016/j.bmcl.2017.09.065
https://doi.org/10.1016/j.bmcl.2017.09.065
Autor:
James T. Patterson, Gunnar F. Kaufmann, Heyue Zhou, Tong Zhu, Bryan Jones, Ghazi Atassi, Lisa Kerwin, Lisa Carmody, Edwige Gros, Yanwen Fu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3647-3652
Bispecific antibodies (BsAbs) are designed to engage two antigens simultaneously, thus, effectively expanding the ability of antibody-based therapeutics to target multiple pathways within the same cell, engage two separate soluble antigens, bind the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b519269b029bf1a38f25eb5bf72780
https://doi.org/10.1016/j.bmcl.2017.07.021
https://doi.org/10.1016/j.bmcl.2017.07.021