Výsledky vyhledávání - "Ghazi A. Dannan"

Characterization of Pulmonary CYP4B2, Specific Catalyst of Methyl Oxidation of 3-Methylindole

Autor: Swayampakula Ramakanth, Brian A. Carr, Garold S. Yost, Ghazi A. Dannan

Publikováno v: Molecular Pharmacology. 63:1137-1147

The selective toxicity of chemicals to lung tissues is predominantly mediated by the selective expression of certain pulmonary cytochrome P450 enzymes. This report describes the purification, cloning, and characterization of a unique enzyme, CYP4B2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bb0213c0a28eeac3fc026b43be1068
https://doi.org/10.1124/mol.63.5.1137

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Liver microsomal enzyme induction and toxicity studies with 2,4,5,3′,4′-pentabromobiphenyl

Autor: J. D. Krehbiel, Stuart D. Sleight, Pamela J. Fraker, Ghazi A. Dannan, Steven D. Aust

Publikováno v: Toxicology and Applied Pharmacology. 64:187-203

A relatively minor component of Firemaster, 2,4,5,3′,4′-pentabromobiphenyl (PenBB), was purified and compared to the effects of Firemaster and 3,4,5,3′,4′,5′-hexabromobiphenyl (HBB). Male rats were given 90 mg/kg, ip, of PenBB or Firemaster

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5e41483fd9eba29c24297cfacfe88b
https://doi.org/10.1016/0041-008x(82)90215-0

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2,4,5,3′,4′,5′-hexabromobiphenyl is both a 3-methylcholanthrene-and a phenobarbital-type inducer of microsomal drug metabolizing enzymes

Autor: Lawrence C. Besaw, Steven D. Aust, Ghazi A. Dannan, Robert W. Moore

Publikováno v: Biochemical and Biophysical Research Communications. 85:450-458

Summary The effects of 2, 4,5, 3′, 4′,5′-hexabromobiphenyl (HBB) on hepatic microsomal drug metabolizing enzymes have been determined. Male rats were injected ip with 90 mg HBB/kg and sacrificed 7 days later. HBB increased liver weight and micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39dda2b54e4efd47af8604d1f0383ed0
https://doi.org/10.1016/s0006-291x(78)80063-1

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Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450

Autor: Ghazi A. Dannan, David J. Waxman, F. P. Guengerich

Publikováno v: Journal of Biological Chemistry. 261:10728-10735

Neonatal gonadectomy studies and hormonal replacement regimens were employed to characterize the regulation of delta 4-steroid 5 alpha-reductase, microsomal flavin-containing monooxygenase, and several forms of rat hepatic microsomal cytochrome P-450

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6484727ba8fcb7b436a21653569dce4
https://doi.org/10.1016/s0021-9258(18)67446-0

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Toxicity and microsomal enzyme induction effects of several polybrominated biphenyls of firemaster1

Autor: Steven D. Aust, Stuart D. Sleight, Ghazi A. Dannan

Publikováno v: Fundamental and Applied Toxicology. 2:313-321

Some toxicological and pharmacological effects of 2,4,5,2′,5′-penta- (congener 1), 2,3,4,2′,4′,5′-hexa- (congener 5), 2,4,5,3′,4′,5′-hexa- (congener 6), 2,3,4,5,3′,4′,-hexa- (congener 7), and 2,3,4,5,2′,3′,4′-hepta-bromobiph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf3de13f6eadf917f40d9d7493439725
https://doi.org/10.1016/s0272-0590(82)80011-0

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Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners

Autor: L S Kaminsky, Steven D. Aust, Ghazi A. Dannan, F. P. Guengerich

Publikováno v: Journal of Biological Chemistry. 258:1282-1288

Specific immunochemical techniques were used to quantitate the levels of eight isozymes of cytochrome P-450 (P-450) and epoxide hydrolase in liver microsomes of untreated rats and rats treated with phenobarbital, 3-methylcholanthrene, a mixture of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10a57f32589bc7218f87b664a3c347d9
https://doi.org/10.1016/s0021-9258(18)33190-9

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Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

Autor: Ghazi A. Dannan, David J. Waxman, F P Guengerich

Publikováno v: Biochemistry. 24(16)

The influence of age, sex, and hormonal status on the expression of eight rat hepatic cytochrome P-450 (P-450) isoenzymes was evaluated by both catalytic and immunochemical methods. The male specificity of P-450 2c(male)/UT-A, the major microsomal st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61ae908e751f5917365568a9e52e3d8
https://pubmed.ncbi.nlm.nih.gov/4052406

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Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450)

Autor: Ghazi A. Dannan, F. Peter Guengerich, Laurence S. Kaminsky

Publikováno v: European journal of biochemistry. 141(1)

The composition of isozymes of hepatic microsomal cytochrome P-450 (P-450) from C57BL/6 (B6) and DBA/2 (D2) inbred strains of mice, uninduced and treated with phenobarbital (PB), pregnenolone-16 alpha-carbonitrile (PCN), and beta-naphthoflavone (BNF)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16da91b00f8ad279010c50336c3b8c15
https://pubmed.ncbi.nlm.nih.gov/6723656

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