Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ghazaleh M. Shahriary"'
Autor:
Jamie Zagozewski, Stephanie Borlase, Brent J. Guppy, Ludivine Coudière-Morrison, Ghazaleh M. Shahriary, Victor Gordon, Lisa Liang, Stephen Cheng, Christopher J. Porter, Rhonda Kelley, Cynthia Hawkins, Jennifer A. Chan, Yan Liang, Jingjing Gong, Carolina Nör, Olivier Saulnier, Robert J. Wechsler-Reya, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
RNA sequencing of MEK inhibitor (selumetinib)-treated tumors reveals an upregulation of the JAK/STAT3 pathway, with combinatorial therapeutic strategies of JAK/STAT3 inhibitors and selumetinib investigated for the SHH subgroup of medulloblastoma.
Externí odkaz:
https://doaj.org/article/7089de720db644bf9d6c9ef8dd5e7822
Autor:
Jamie Zagozewski, Ghazaleh M. Shahriary, Ludivine Coudière Morrison, Olivier Saulnier, Margaret Stromecki, Agnes Fresnoza, Gareth Palidwor, Christopher J. Porter, Antoine Forget, Olivier Ayrault, Cynthia Hawkins, Jennifer A. Chan, Maria C. Vladoiu, Lakshmikirupa Sundaresan, Janilyn Arsenio, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.
Externí odkaz:
https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb2070
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Microglia play diverse roles in homeostasis and pathology of the central nervous system (CNS). Their response to injury or insult is critical for initiating neuroinflammation and tissue damage as well as resolution of inflammation and wound healing.
Externí odkaz:
https://doaj.org/article/08188ba4eda84917a096af6137c77ef2
Autor:
Ludivine Coudière Morrison, Jennifer A. Chan, Margaret Stromecki, Gareth A. Palidwor, Maria C. Vladoiu, Cynthia Hawkins, Jamie Zagozewski, Tamra E. Werbowetski-Ogilvie, Ghazaleh M. Shahriary, Janilyn Arsenio, Olivier Ayrault, Lakshmikirupa Sundaresan, Vijay Ramaswamy, Antoine Forget, Agnes Fresnoza, Christopher J. Porter, Michael D. Taylor, Olivier Saulnier
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation are not well characterized. Here, we perform extensive multiomic analyses to identify an OTX2 regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459b190d3ef9954563e763e01f7f9b7e
https://www.hal.inserm.fr/inserm-02946666/document
https://www.hal.inserm.fr/inserm-02946666/document
Autor:
Soheila Karimi-Abdolrezaee, Arsalan Alizadeh, Hardeep Kataria, Scott M. Dyck, Kallivalappil T. Santhosh, Ghazaleh M. Shahriary, Dung H. Nguyen
Publikováno v:
Glia. 65:1152-1175
Spinal cord injury (SCI) results in glial activation and neuroinflammation, which play pivotal roles in the secondary injury mechanisms with both pro- and antiregeneration effects. Presently, little is known about the endogenous molecular mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4359019c88297066d0d7ad28b5cd7640
https://doi.org/10.1002/glia.23150
https://doi.org/10.1002/glia.23150
Publikováno v:
Stem Cells International
Stem Cells International, Vol 2019 (2019)
Stem Cells International, Vol 2019 (2019)
Microglia play diverse roles in homeostasis and pathology of the central nervous system (CNS). Their response to injury or insult is critical for initiating neuroinflammation and tissue damage as well as resolution of inflammation and wound healing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d2977f126120b8cccaea6d15c747e8
http://europepmc.org/articles/PMC6476022
http://europepmc.org/articles/PMC6476022
Autor:
Hardeep Kataria, Soheila Karimi-Abdolrezaee, Ghazaleh M. Shahriary, Ryan Nathan Henrie, James A. Thliveris, Arsalan Alizadeh, Shekoofeh Saboktakin Rizi, Kallivalappil T. Santhosh
Publikováno v:
Glia. 66(3)
Oligodendroglial cell death and demyelination are hallmarks of neurotrauma and multiple sclerosis that cause axonal damage and functional impairments. Remyelination remains a challenge as the ability of endogenous precursor cells for oligodendrocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eba3064b18bcae05954270e0073f0a
https://pubmed.ncbi.nlm.nih.gov/29148104
https://pubmed.ncbi.nlm.nih.gov/29148104
Autor:
Antoine Forget, Michael D. Taylor, Jamie Zagozewski, Jennifer A. Chan, Tamra E. Werbowetski-Ogilvie, Cynthia Hawkins, Agnes Fresnoza, Gareth A. Palidwor, Ludivine Coudière Morrison, Olivier Saulnier, Olivier Ayrault, Christopher J. Porter, Margaret Stromecki, Vijay Ramaswamy, Maria C. Vladoiu, Ghazaleh M. Shahriary
Publikováno v:
Neuro Oncol
The majority of Group 3 medulloblastomas (MB) exhibit amplification or increased expression of OTX2. OTX2 is primarily known as an oncogenic driver of tumor growth and cell cycle progression in Group 3 MB; however, its role as a repressor of differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e9655b67e60257d8eee673ffe20c0c
https://doi.org/10.1093/neuonc/noz175.804
https://doi.org/10.1093/neuonc/noz175.804