Výsledky vyhledávání - "Ghassan J Maghzal"

Akademický článek

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

Publikováno v: eLife, Vol 7 (2018)

Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a ra

Externí odkaz: https://doaj.org/article/8a5796fc74b24c25b9c3c989e6b15e61

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Akademický článek

AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation.

Autor: Jason K Cullen, Norazian Abdul Murad, Abrey Yeo, Matthew McKenzie, Micheal Ward, Kok Leong Chong, Nicole L Schieber, Robert G Parton, Yi Chieh Lim, Ernst Wolvetang, Ghassan J Maghzal, Roland Stocker, Martin F Lavin

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148213 (2016)

Autosomal recessive ataxias are a clinically diverse group of syndromes that in some cases are caused by mutations in genes with roles in the DNA damage response, transcriptional regulation or mitochondrial function. One of these ataxias, known as Au

Externí odkaz: https://doaj.org/article/32ca33b3dacf4526975bede3ed24da0b

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Akademický článek

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

Publikováno v: Redox Biology, Vol 46, Iss , Pp 102127- (2021)

Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a rang

Externí odkaz: https://doaj.org/article/e5e37048d10e4f0db080cc6d7d4696a3

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Akademický článek

Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques

Autor: Nay Min Htun, Yung Chih Chen, Bock Lim, Tara Schiller, Ghassan J. Maghzal, Alex L. Huang, Kirstin D. Elgass, Jennifer Rivera, Hans G. Schneider, Bayden R. Wood, Roland Stocker, Karlheinz Peter

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

Atherosclerosis diagnosis relies primarily on imaging and early detection of high-risk atherosclerotic plaques is important for risk stratification of patients and stabilization therapies. Here Htun et al. demonstrate that vulnerable atherosclerotic

Externí odkaz: https://doaj.org/article/075fffd059534647982193229c37d9e4

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Akademický článek

Behavioral and cognitive data in mice with different tryptophan-metabolizing enzymes knocked out

Autor: Lay Khoon Too, Kong M. Li, Cacang Suarna, Ghassan J. Maghzal, Roland Stocker, Iain S. McGregor, Nicholas H. Hunt

Publikováno v: Data in Brief, Vol 9, Iss C, Pp 275-287 (2016)

This article demonstrates behavioral changes in mice in response to free adaptation and drinking session adaptation modules implemented in their social home environment, the IntelliCage. These data complement the study “Deletion of TDO2, IDO-1 and

Externí odkaz: https://doaj.org/article/f350cec6827a4a8ba5b378fdeaac196c

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Effect of chronic mucus hypersecretion on treatment responses to inhaled therapies in patients with chronic obstructive pulmonary disease: Post hoc analysis of the IMPACT trial

Autor: Philip J. Thompson, Gerard J. Criner, Mark T. Dransfield, David M. G. Halpin, MeiLan K. Han, David A. Lipson, Ghassan J. Maghzal, Fernando J. Martinez, Dawn Midwinter, Dave Singh, Lee Tombs, Robert A. Wise

Publikováno v: Respirology (Carlton, Vic.)REFERENCES. 27(12)

Chronic mucus hypersecretion (CMH) is a clinical phenotype of COPD. This exploratory post hoc analysis assessed relationship between CMH status and treatment response in IMPACT.Patients were randomized to once-daily fluticasone furoate/umeclidinium/v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b148640eb928e46773c35177512fca
https://pubmed.ncbi.nlm.nih.gov/36031687

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Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

Publikováno v: Redox Biology
Redox Biology, Vol 46, Iss, Pp 102127-(2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a42dc8296c2423f7fa00c428c954af
https://escholarship.org/uc/item/2vq9169s

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Akademický článek

Heme oxygenase-1 deficiency alters erythroblastic island formation, steady-state erythropoiesis and red blood cell lifespan in mice

Autor: Stuart T. Fraser, Robyn G. Midwinter, Lucy A. Coupland, Stephanie Kong, Birgit S. Berger, Jia Hao Yeo, Osvaldo Cooley Andrade, Deborah Cromer, Cacang Suarna, Magda Lam, Ghassan J. Maghzal, Beng H. Chong, Christopher R. Parish, Roland Stocker

Publikováno v: Haematologica, Vol 100, Iss 5 (2015)

Heme oxygenase-1 is critical for iron recycling during red blood cell turnover, whereas its impact on steady-state erythropoiesis and red blood cell lifespan is not known. We show here that in 8- to 14-week old mice, heme oxygenase-1 deficiency adver

Externí odkaz: https://doaj.org/article/a784017e99d7465b947593a790120954

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Hmox1 (Heme Oxygenase-1) Protects Against Ischemia-Mediated Injury via Stabilization of HIF-1α (Hypoxia-Inducible Factor-1α)

Autor: James Cantley, Robyn G. Midwinter, Kim H. Chan, Weiyu Chen, Anita Ayer, Ghassan J. Maghzal, Stephanie M.Y. Kong, Louise L. Dunn, Martin K.C. Ng, Roland Stocker, Sergey Tumanov

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 41(1)

Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the degradation of heme to carbon monoxide, iron, and biliverdin. Induction of Hmox1 and its products protect against cardiovascular disease, including ischemic injury. Hmo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ef5b0a5ed20e9680db4f96b4c82120
https://pubmed.ncbi.nlm.nih.gov/33207934

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