Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Ghanshyam Swarup"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101672- (2024)
Autophagy has emerged as a critical innate immune mechanism for host elimination of intracellular pathogens, however, the role of the autophagy receptor Optineurin during mycobacterial infection is not fully understood. To address this lacuna, we inf
Externí odkaz:
https://doaj.org/article/06c3ba4c4e5a419ab08b3463e66f0c20
Publikováno v:
Communicative & Integrative Biology, Vol 11, Iss 2, Pp 1-4 (2018)
Autophagy is an essential physiological process that maintains cellular homeostasis by eliminating harmful protein aggregates, damaged organelles and certain pathogens through lysosomal degradation. During autophagy specialized structures, known as a
Externí odkaz:
https://doaj.org/article/a438eb49ae2f4fda84887551bb27e22d
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract A photoreceptor cell line, 661W, derived from a mouse retinal tumor that expresses several markers of cone photoreceptor cells has been described earlier. However, these cells can be differentiated into neuronal cells. Here, we report that t
Externí odkaz:
https://doaj.org/article/72730e92429a43929b5a51022c8d1c75
Autor:
Ghanshyam Swarup, Zuberwasim Sayyad
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Optineurin (OPTN) is an adaptor protein that is involved in mediating a variety of cellular processes such as signaling, vesicle trafficking, and autophagy. Certain mutations in OPTN (gene OPTN) are associated with primary open angle glaucoma, a lead
Externí odkaz:
https://doaj.org/article/f90304d485e54593be198fcd6a95b46e
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138289 (2015)
Certain missense mutations in optineurin/OPTN and amplification of TBK1 are associated with normal tension glaucoma. A glaucoma-associated variant of OPTN, M98K, induces autophagic degradation of transferrin receptor (TFRC) and death in retinal cells
Externí odkaz:
https://doaj.org/article/5c441bcc643f4f7abc1b1937270793f5
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95758 (2014)
The protein optineurin coded by OPTN gene is involved in several functions including regulation of endocytic trafficking, autophagy and signal transduction. Certain missense mutations in the gene OPTN cause normal tension glaucoma. A glaucoma-causing
Externí odkaz:
https://doaj.org/article/1a2e61bcc14049d7b6aa99a5b3688c73
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17477 (2011)
The nuclear factor kappa B (NF-κB) regulates genes that function in diverse cellular processes like inflammation, immunity and cell survival. The activation of NF-κB is tightly controlled and the deubiquitinase CYLD has emerged as a key negative re
Externí odkaz:
https://doaj.org/article/4cd6f29d210840b79b67394f60e202f9
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5114 (2009)
Optineurin is a ubiquitously expressed multifunctional cytoplasmic protein encoded by OPTN gene. The expression of optineurin is induced by various cytokines. Here we have investigated the molecular mechanisms which regulate optineurin gene expressio
Externí odkaz:
https://doaj.org/article/9331527a054c4387b061acbbb712d35b
Autor:
Zuberwasim Sayyad, Sreeram Kaveti, Debanjan Bhattacharjee, Dhiviya Vedagiri, Nishant Jain, Ghanshyam Swarup
Publikováno v:
The FEBS Journal.
Autor:
Nandini Rangaraj, Vipul Vaibhava, Cherukuri Sudhakar, Shivranjani C Moharir, Ghanshyam Swarup
Transferrin and its receptor play an important role in iron homeostasis. Binding of transferrin to its receptor (TFRC, transferrin receptor protein 1) initiates endocytic trafficking and subsequent recycling of TFRC to the plasma membrane. RAB8-posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a701987d3a14e697c6ab7027bcdfebc
https://doi.org/10.1101/2023.02.06.527405
https://doi.org/10.1101/2023.02.06.527405