Novel benzenesulfonamides as dual VEGFR2/FGFR1 inhibitors targeting breast cancer: Design, synthesis, anticancer activity and in silico studies.

Autor: Hassan RM; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Ali IH; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., El Kerdawy AM; School of Pharmacy, College of Health and Science, University of Lincoln, Joseph Banks Laboratories, Green Lane, Lincoln, United Kingdom; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Abo-Elfadl MT; Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo 12622, Egypt; Biochemistry Department, Biotechnology Research Institute, National Research Centre, Dokki, Cairo, Egypt., Ghannam IAY; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: iman.youssef.ghannam@gmail.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Nov; Vol. 152, pp. 107728. Date of Electronic Publication: 2024 Aug 17.

Diphenyl urea-benzylidene acetohydrazide hybrids as fibroblast growth factor receptor 1 inhibitors and anticancer agents.

Autor: Abdel-Mohsen HT; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt., Nageeb AM; High Throughput Molecular and Genetic Technology Lab, Center of Excellence for Advanced Sciences, Biochemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt., Ghannam IAY; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt.

Publikováno v: Drug development research [Drug Dev Res] 2024 Sep; Vol. 85 (6), pp. e22249.

Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance.

Autor: Hassan RM; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt. Electronic address: rashahassan_pharma@yahoo.ca., Abd El-Maksoud MS; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Ghannam IAY; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, 12622, Egypt., El-Azzouny AA; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Aboul-Enein MN; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt. Electronic address: mnaboulenein@yahoo.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 15; Vol. 262, pp. 115867. Date of Electronic Publication: 2023 Oct 11.

Design, synthesis and anticancer activity of novel 2-arylbenzimidazole/2-thiopyrimidines and 2-thioquinazolin-4(3H)-ones conjugates as targeted RAF and VEGFR-2 kinases inhibitors.

Autor: Ali IH; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Abdel-Mohsen HT; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Mounier MM; Department of Pharmacognosy, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Abo-Elfadl MT; Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo 12622, Egypt; Biochemistry Department, Biotechnology Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., El Kerdawy AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Department of Organic and Pharmaceutical Chemistry, School of Pharmacy, NewGiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, Cairo, Egypt., Ghannam IAY; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: iman.youssef.ghannam@gmail.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2022 Sep; Vol. 126, pp. 105883. Date of Electronic Publication: 2022 May 21.

Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design, synthesis and in vitro/in vivo biological evaluation.

Autor: Hassan RM; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt., Aboutabl ME; Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), 33 El Bohouth St., P.O. 12622, Dokki, Giza, Egypt., Bozzi M; Dipartimento Universitario di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore di Roma, Largo F. Vito 1, 00168 Roma, Italy; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta'- SCITEC (CNR) Sede di Roma, Largo F. Vito 1, 00168 Roma, Italy. Electronic address: Manuela.Bozzi@unicatt.it., El-Behairy MF; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Egypt., El Kerdawy AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Department of Pharmaceutical Chemistry, School of Pharmacy, New Giza University, Newgiza, km 22 Cairo-Alexandria Desert Road, Cairo, Egypt., Sampaolese B; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta'- SCITEC (CNR) Sede di Roma, Largo F. Vito 1, 00168 Roma, Italy., Desiderio C; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta'- SCITEC (CNR) Sede di Roma, Largo F. Vito 1, 00168 Roma, Italy., Vincenzoni F; Dipartimento Universitario di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore di Roma, Largo F. Vito 1, 00168 Roma, Italy; Fondazione Policlinico Universitario 'A. Gemelli', IRCCS, Largo A. Gemelli 8, 00168 Roma, Italy., Sciandra F; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta'- SCITEC (CNR) Sede di Roma, Largo F. Vito 1, 00168 Roma, Italy. Electronic address: francesca.sciandra@cnr.it., Ghannam IAY; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: iman.youssef.ghannam@gmail.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Oct; Vol. 115, pp. 105170. Date of Electronic Publication: 2021 Jul 16.