Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Ghanim Ullah"'
Autor:
Jesutofunmi Ayo Fajemisin, Glebys Gonzalez, Stephen A. Rosenberg, Ghanim Ullah, Gage Redler, Kujtim Latifi, Eduardo G. Moros, Issam El Naqa
Publikováno v:
Tomography, Vol 10, Iss 9, Pp 1439-1454 (2024)
Magnetic resonance imaging (MRI) is known for its accurate soft tissue delineation of tumors and normal tissues. This development has significantly impacted the imaging and treatment of cancers. Radiomics is the process of extracting high-dimensional
Externí odkaz:
https://doaj.org/article/13cf0027437c438aba098cee878ac967
Publikováno v:
eLife, Vol 13 (2024)
Ischemia leads to a severe dysregulation of glutamate homeostasis and excitotoxic cell damage in the brain. Shorter episodes of energy depletion, for instance during peri-infarct depolarizations, can also acutely perturb glutamate signaling. It is le
Externí odkaz:
https://doaj.org/article/5cfb633bde8249dca841a174ef157cc7
Autor:
Bettina Kolen, Bart Borghans, Daniel Kortzak, Victor Lugo, Cora Hannack, Raul E. Guzman, Ghanim Ullah, Christoph Fahlke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Vesicular glutamate transporters accumulate glutamate in synaptic vesicles, where they also function as a major Cl- efflux pathway. Here we combine heterologous expression and cellular electrophysiology with mathematical modeling to understa
Externí odkaz:
https://doaj.org/article/d23f45dcf0ea4ebfa5e44b1ac9fca332
Autor:
Katharina Everaerts, Pawan Thapaliya, Nils Pape, Simone Durry, Sara Eitelmann, Eleni Roussa, Ghanim Ullah, Christine R. Rose
Publikováno v:
Cells, Vol 12, Iss 23, p 2675 (2023)
Ischemic conditions cause an increase in the sodium concentration of astrocytes, driving the breakdown of ionic homeostasis and exacerbating cellular damage. Astrocytes express high levels of the electrogenic sodium-bicarbonate cotransporter1 (NBCe1)
Externí odkaz:
https://doaj.org/article/b08869e758e243e296f1ac4d9b6d80b9
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Emerging evidence indicates that neuronal activity-evoked changes in sodium concentration in astrocytes Naa represent a special form of excitability, which is tightly linked to all other major ions in the astrocyte and extracellular space, as well as
Externí odkaz:
https://doaj.org/article/98fd5c40ce0148e1874f462dd94885c8
Publikováno v:
Cells, Vol 11, Iss 22, p 3630 (2022)
Strong evidence indicates that amyloid beta (Aβ) inflicts its toxicity in Alzheimer’s disease (AD) by promoting uncontrolled elevation of cytosolic Ca2+ in neurons. We have previously shown that synthetic Aβ42 oligomers stimulate abnormal intrace
Externí odkaz:
https://doaj.org/article/79a6e5bcd9044971b2363bc8b45e2305
Publikováno v:
Cells, Vol 11, Iss 14, p 2167 (2022)
Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca2+ influx through membrane-resident voltage-gated Ca2+ channels (VGCCs). Moreover, accumulating evidence indicates that the endoplasmic reticulum (ER) is extensivel
Externí odkaz:
https://doaj.org/article/7be7f90cb2514c3c933243ce37cdee56
Autor:
Manasa Kanithi, Sunil Junapudi, Syed Islamuddin Shah, Alavala Matta Reddy, Ghanim Ullah, Bojjibabu Chidipi
Publikováno v:
Cells, Vol 11, Iss 10, p 1688 (2022)
Toxins present in cigarette and e-cigarette smoke constitute a significant cause of illnesses and are known to have fatal health impacts. Specific mechanisms by which toxins present in smoke impair cell repair are still being researched and are of pr
Externí odkaz:
https://doaj.org/article/e17bdacbd1eb4212b69b1e1fe700209d
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0223014 (2019)
Fragmentation of mitochondrial network has been implicated in many neurodegenerative, renal, and metabolic diseases. However, a quantitative measure of the microscopic parameters resulting in the impaired balance between fission and fusion of mitocho
Externí odkaz:
https://doaj.org/article/fab1ac2d85774fddb7e96db651223461
Autor:
Bojjibabu Chidipi, Syed Islamuddin Shah, Michelle Reiser, Manasa Kanithi, Amanda Garces, Byeong J. Cha, Ghanim Ullah, Sami F. Noujaim
Publikováno v:
Cells, Vol 10, Iss 5, p 1202 (2021)
In the heart, mitochondrial homeostasis is critical for sustaining normal function and optimal responses to metabolic and environmental stressors. Mitochondrial fusion and fission are thought to be necessary for maintaining a robust population of mit
Externí odkaz:
https://doaj.org/article/d02aa3fdae3e4f77a62e01fcf8b723ec