Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ghania Chikh"'
Publikováno v:
Vaccines, Vol 4, Iss 2, p 14 (2016)
Endosomal Toll-like receptors (TLR) such as TLR3, 7, 8 and 9 recognize pathogen associated nucleic acids. While DNA sequence does influence degree of binding to and activation of TLR9, it also appears to influence the ability of the ligand to reach t
Externí odkaz:
https://doaj.org/article/1a4951b0392c4b94986a5382708cbae1
Autor:
Heather L. Davis, Brian Robert Champion, Ghania Chikh, James D. Fraser, Lu Zhang, James R. Merson, Michael J. McCluskie, Jennifer Marie Thorn, Risini D. Weeratna
Publikováno v:
Immunity, Inflammation and Disease
The anti‐human immunoglobulin E (IgE) monoclonal antibody, omalizumab (Xolair®, Genentech, South San Fransisco, CA), is effective in the treatment of poorly controlled moderate to severe allergic asthma and chronic idiopathic urticaria. It acts by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a52465f12853abfab9920596b30c2b
https://doi.org/10.1002/iid3.98
https://doi.org/10.1002/iid3.98
Autor:
Richard Klasa, Marcel B. Bally, Gigi N.C. Chiu, Rebecca Ng, Jesse Popov, Anita I Kapanen, Ghania Chikh, Catherine Tucker, Christopher Turner
Publikováno v:
Nanomedicine. 6:1575-1591
Aims: The activity of therapeutic antibodies can be enhanced by creating multivalent constructs, such as antibody lipid nanoparticles (LNPs). Here, we examine differences between rituximab (Ritux) and Ritux-LNPs in terms of their indirect mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4ad2ea0dbb969d3532b660961a06a9
https://doi.org/10.2217/nnm.11.50
https://doi.org/10.2217/nnm.11.50
Autor:
Arthur M. Krieg, Marion Jurk, Rachel Luu, Alain Vicari, Bettina Schulte, Ghania Chikh, Denise Richardt-Pargmann, Andrea Kritzler, Catherine Lampron, Jörg Vollmer
Publikováno v:
Nucleic Acid Therapeutics. 21:201-214
Microbial infections trigger a multiplicity of responses in the host via innate immune sensors, including the Toll-like receptors (TLRs). TLR7 and TLR8, located in endosomes, detect pathogen-derived RNA, which can be mimicked by synthetic single-stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9243fbeae12856bbd6e7fc91218559b3
https://doi.org/10.1089/nat.2011.0298
https://doi.org/10.1089/nat.2011.0298
Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles
Autor:
Susan D. de Jong, Pieter R. Cullis, Sameersingh G. Raney, Laura Sekirov, Jan P. Dutz, Ghania Chikh, Mikameh Kazem, Ying K. Tam, Kaley D. Wilson
Publikováno v:
International Immunology. 21:757-767
Although it is well documented that the immunological activity of cytosine-guanine (CpG) motifs is abrogated by 5' methylation of the cytosine residue, encapsulation within stabilized lipid nanoparticles endows these methylated cytosine-guanine- (mCp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996d6b6640c815b4beb30496c1ecd9fa
https://doi.org/10.1093/intimm/dxp044
https://doi.org/10.1093/intimm/dxp044
Autor:
Dana Masin, Richard Klasa, Alastair H. Kyle, Anita I Kapanen, Ian M. Wilson, Catherine Tucker, Brad G. Hoffman, Ghania Chikh, Randy D. Gascoyne, Marcel B. Bally
Publikováno v:
Molecular Cancer Therapeutics. 7:749-758
Molecular mechanisms responsible for lymphoma resistance to apoptosis often involve the bcl-2 pathway. In this study, we investigated the cell signaling pathways activated in bcl-2-overexpressing human mantle cell lymphoma cell lines (JVM-2 and Z-138
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493dd98c9fb4ae5276706651e88928da
https://doi.org/10.1158/1535-7163.mct-07-0302
https://doi.org/10.1158/1535-7163.mct-07-0302
Autor:
Ghania Chikh, Laura Sekirov, Jennifer Takasaki, Steven M. Ansell, Sameersingh G. Raney, Ying Tam, Irina Brodsky
Publikováno v:
Bioconjugate Chemistry. 17:451-458
A mixture of ionizable cationic lipids, steric barrier lipids, and colipids is used to encapsulate oligonucleotide DNA in lipidic particles called SALP. This material is under development as an adjuvant for vaccines. Previously we have shown that cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8c8a686c08513f658958ae45f756ac
https://doi.org/10.1021/bc050052j
https://doi.org/10.1021/bc050052j
Autor:
Jean-Claude Meunier, Marie-Paule Schutze-Redelmeier, Marcel B. Bally, Wai Ming Li, Ghania Chikh
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1567:204-212
The therapeutic potential of selected peptides and proteins is enormous, with applications ranging from use as therapeutic vaccines, as modulators of intracellular signaling pathways and as highly selective agents capable of recognizing unique extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af723cf2962d7e68acc89962e1975e0c
Autor:
Natalie Tam, Connor McCarthy, Anthony Cheung, Dauphinee Shauna, Jeremy Dupal-Chicoine, Ghania Chikh, Eric Hsu
Publikováno v:
Gastroenterology. 152:S1311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55261c9b87d465f2d8d49a30ad832837
https://doi.org/10.1016/s0016-5085(17)34366-4
https://doi.org/10.1016/s0016-5085(17)34366-4
Autor:
Keshab Bhattacharya, Jennifer Marie Thorn, Michael J. McCluskie, Ghania Chikh, Jari I. Finneman, Dana M. Evans, Ningli Zhang, Heather L. Davis, James R. Merson, Paul Robert Mehelic, David Robert Stead, Michele Bailey Piatchek, Janna Cartier, Parag Kolhe
Publikováno v:
International immunopharmacology. 25(2)
Anti-nicotine vaccines aim to prevent nicotine entering the brain, and thus reduce or eliminate the reward that drives nicotine addiction. Those tested in humans to date have failed to improve quit rates over placebo, possibly because antibody (Ab) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f927cafb6fa8190aeb42bfc93f4eb5
https://pubmed.ncbi.nlm.nih.gov/25737198
https://pubmed.ncbi.nlm.nih.gov/25737198