Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ghamdan Al-Eryani"'
Autor:
Taopeng Wang, Michael J. Roach, Kate Harvey, Javier Escudero Morlanes, Beata Kiedik, Ghamdan Al-Eryani, Alissa Greenwald, Nikolaos Kalavros, Felipe Segato Dezem, Yuling Ma, Yered H. Pita-Juarez, Kellie Wise, Cyril Degletagne, Anna Elz, Azi Hadadianpour, Jack Johanneson, Fiona Pakiam, Heeju Ryu, Evan W. Newell, Laurie Tonon, Andrew Kohlway, Tingsheng Drennon, Jawad Abousoud, Ryan Stott, Paul Lund, Jens Durruthy, Andres F. Vallejo, Wenyan Li, Robert Salomon, Dominik Kaczorowski, Joanna Warren, Lisa M. Butler, Sandra O’Toole, Jasmine Plummer, Ioannis S. Vlachos, Joakim Lundeberg, Alexander Swarbrick, Luciano G. Martelotto
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Formalin-fixed paraffin-embedded (FFPE) samples are valuable but underutilized in single-cell omics research due to their low RNA quality. In this study, leveraging a recent advance in single-cell genomic technology, we introduce snPATHO-seq
Externí odkaz:
https://doaj.org/article/e72696809e1b4d6fbd26435761d09282
Autor:
Khoa A. Tran, Venkateswar Addala, Rebecca L. Johnston, David Lovell, Andrew Bradley, Lambros T. Koufariotis, Scott Wood, Sunny Z. Wu, Daniel Roden, Ghamdan Al-Eryani, Alexander Swarbrick, Elizabeth D. Williams, John V. Pearson, Olga Kondrashova, Nicola Waddell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cells within the tumour microenvironment (TME) can impact tumour development and influence treatment response. Computational approaches have been developed to deconvolve the TME from bulk RNA-seq. Using scRNA-seq profiling from breast tumour
Externí odkaz:
https://doaj.org/article/f9576e0a75aa4ba79006d2ea6d404d7b
Autor:
Louise A. Baldwin, Nenad Bartonicek, Jessica Yang, Sunny Z. Wu, Niantao Deng, Daniel L. Roden, Chia-Ling Chan, Ghamdan Al-Eryani, Damien J. Zanker, Belinda S. Parker, Alexander Swarbrick, Simon Junankar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Understanding the molecular mechanisms of cancer immunoediting could provide insight into resistance to immunotherapy. Here, DNA barcoding provides evidence of ongoing immunoediting during metastasis and treatment with anti-PD1 and anti-CTLA4, and id
Externí odkaz:
https://doaj.org/article/65c4b7296f594b7ab39104a26aaa50c8
Autor:
Alma Andersson, Ludvig Larsson, Linnea Stenbeck, Fredrik Salmén, Anna Ehinger, Sunny Z. Wu, Ghamdan Al-Eryani, Daniel Roden, Alex Swarbrick, Åke Borg, Jonas Frisén, Camilla Engblom, Joakim Lundeberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
While transcriptomics have enhanced our understanding for cancer, spatial transcriptomics enable the characterisation of cellular interactions. Here, the authors integrate single cell data with spatial information for HER2 + tumours and develop tools
Externí odkaz:
https://doaj.org/article/67d1fcd9923241f29ad4682c878c5800
Autor:
Sunny Z. Wu, Daniel L. Roden, Ghamdan Al-Eryani, Nenad Bartonicek, Kate Harvey, Aurélie S. Cazet, Chia-Ling Chan, Simon Junankar, Mun N. Hui, Ewan A. Millar, Julia Beretov, Lisa Horvath, Anthony M. Joshua, Phillip Stricker, James S. Wilmott, Camelia Quek, Georgina V. Long, Richard A. Scolyer, Bertrand Z. Yeung, Davendra Segara, Cindy Mak, Sanjay Warrier, Joseph E. Powell, Sandra O’Toole, Elgene Lim, Alexander Swarbrick
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult
Externí odkaz:
https://doaj.org/article/a5ef0303cd954e8fa8a1cccb863078c6
Autor:
Mandeep Singh, Ghamdan Al-Eryani, Shaun Carswell, James M. Ferguson, James Blackburn, Kirston Barton, Daniel Roden, Fabio Luciani, Tri Giang Phan, Simon Junankar, Katherine Jackson, Christopher C. Goodnow, Martin A. Smith, Alexander Swarbrick
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Single cell RNA sequencing generates short reads from one end of a template, providing incomplete transcript coverage and limiting identification of diverse sequences such as antigen receptors. Here the authors combine long read nanopore sequencing w
Externí odkaz:
https://doaj.org/article/c60a66377d0242a7a325fe287cec34d3
Autor:
Kiranj Chaudagar, Hanna M. Hieromnimon, Rimpi Khurana, Brian Labadie, Taghreed Hirz, Shenglin Mei, Raisa Hasan, Jordan Shafran, Anne Kelley, Eva Apostolov, Ghamdan Al-Eryani, Kate Harvey, Srikrishnan Rameshbabu, Mayme Loyd, Kaela Bynoe, Catherine Drovetsky, Ani Solanki, Erica Markiewicz, Marta Zamora, Xiaobing Fan, Stephan Schürer, Alex Swarbrick, David B. Sykes, Akash Patnaik
Publikováno v:
Clinical Cancer Research. 29:1952-1968
Purpose: Phosphatase and tensin homolog (PTEN) loss of function occurs in approximately 50% of patients with metastatic castrate-resistant prostate cancer (mCRPC), and is associated with poor prognosis and responsiveness to standard-of-care therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be68d3800b4a39cbb166c623f9acb33
https://doi.org/10.1158/1078-0432.ccr-22-3350
https://doi.org/10.1158/1078-0432.ccr-22-3350
Autor:
Taopeng Wang, Kate Harvey, John Reeves, Daniel L. Roden, Nenad Bartonicek, Jessica Yang, Ghamdan Al-Eryani, Dominik Kaczorowski, Chia-Ling Chan, Joseph Powell, Sandra O’Toole, Elgene Lim, Alexander Swarbrick
BackgroundSpatial transcriptomic technologies are powerful tools for resolving the spatial heterogeneity of gene expression in tissue samples. However, little evidence exists on relative strengths and weaknesses of the various available technologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::870b4b87d7f1713fbc83300d00d5d066
https://doi.org/10.1101/2023.04.06.535805
https://doi.org/10.1101/2023.04.06.535805
Autor:
Akash Patnaik, David B. Sykes, Alex Swarbrick, Stephan Schürer, Xiaobing Fan, Marta Zamora, Erica Markiewicz, Ani Solanki, Catherine Drovetsky, Kaela Bynoe, Mayme Loyd, Srikrishnan Rameshbabu, Kate Harvey, Ghamdan Al-Eryani, Eva Apostolov, Anne Kelley, Jordan Shafran, Raisa Hasan, Shenglin Mei, Taghreed Hirz, Brian Labadie, Rimpi Khurana, Hanna M. Hieromnimon, Kiranj Chaudagar
Purpose:Phosphatase and tensin homolog (PTEN) loss of function occurs in approximately 50% of patients with metastatic castrate-resistant prostate cancer (mCRPC), and is associated with poor prognosis and responsiveness to standard-of-care therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabfb09a9cb30f9f1e328f0b008a53c6
https://doi.org/10.1158/1078-0432.c.6563227.v1
https://doi.org/10.1158/1078-0432.c.6563227.v1
Autor:
Akash Patnaik, David B. Sykes, Alex Swarbrick, Stephan Schürer, Xiaobing Fan, Marta Zamora, Erica Markiewicz, Ani Solanki, Catherine Drovetsky, Kaela Bynoe, Mayme Loyd, Srikrishnan Rameshbabu, Kate Harvey, Ghamdan Al-Eryani, Eva Apostolov, Anne Kelley, Jordan Shafran, Raisa Hasan, Shenglin Mei, Taghreed Hirz, Brian Labadie, Rimpi Khurana, Hanna M. Hieromnimon, Kiranj Chaudagar
Supplementary Figure S1. The majority of Pb-Cre; PTENfl/fl Trp53fl/fl mice are de novo resistant to ADT. Supplementary Figure S2. ADT/PI3Ki combination therapy halts prostate tumor growth up to 14 days, followed by development of resistance in majori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998c4977bf8201764c79ff7057327293
https://doi.org/10.1158/1078-0432.22551388
https://doi.org/10.1158/1078-0432.22551388