X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition.

Autor: Volpatti JR; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada.; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Ghahramani-Seno MM; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Mansat M; Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM, UMR-S U1297 and University of Toulouse III, CHU-Rangueil, Toulouse, France., Sabha N; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Sarikaya E; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada.; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Goodman SJ; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, M5S 1A1, Canada., Chater-Diehl E; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Celik A; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Pannia E; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Froment C; Institut de Pharmacologie Et Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France., Combes-Soia L; Institut de Pharmacologie Et Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France., Maani N; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada.; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Yuki KE; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Chicanne G; Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM, UMR-S U1297 and University of Toulouse III, CHU-Rangueil, Toulouse, France., Uusküla-Reimand L; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Monis S; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada.; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Alvi SA; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada., Genetti CA; Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Payrastre B; Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM, UMR-S U1297 and University of Toulouse III, CHU-Rangueil, Toulouse, France.; Laboratoire d'Hématologie, Centre Hospitalier Universitaire (CHU) de Toulouse, Toulouse Cedex, France., Beggs AH; Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Bonnemann CG; Neuromuscular and Neurogenetic Disorders of Childhood Section, NINDS, NIH, Bethesda, MD, USA., Muntoni F; Dubowitz Neuromuscular Centre, NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Institute of Child Health, University College London, London, UK., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada.; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada.; Program for Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Weksberg R; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada.; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada.; Department of Paediatrics, University of Toronto, Toronto, ON, M5S 1A1, Canada.; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Viaud J; Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM, UMR-S U1297 and University of Toulouse III, CHU-Rangueil, Toulouse, France., Dowling JJ; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada. james.dowling@sickkids.ca.; Program for Genetics and Genome Biology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 0A4, Canada. james.dowling@sickkids.ca.; Department of Paediatrics, University of Toronto, Toronto, ON, M5S 1A1, Canada. james.dowling@sickkids.ca.; Division of Neurology, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada. james.dowling@sickkids.ca.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2022 Sep; Vol. 144 (3), pp. 537-563. Date of Electronic Publication: 2022 Jul 17.

Transposase-CRISPR mediated targeted integration (TransCRISTI) in the human genome.

Autor: Rezazade Bazaz M; Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, 9177948974, Mashhad, Iran.; Stem Cell Biology and Regenerative Medicine Research Group, Research Institute of Biotechnology, Ferdowsi University of Mashhad, Azadi Square, 9177948974, Mashhad, Iran., Ghahramani Seno MM; Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, 9177948974, Mashhad, Iran.; Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, 9177948974, Mashhad, Iran., Dehghani H; Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, 9177948974, Mashhad, Iran. dehghani@um.ac.ir.; Stem Cell Biology and Regenerative Medicine Research Group, Research Institute of Biotechnology, Ferdowsi University of Mashhad, Azadi Square, 9177948974, Mashhad, Iran. dehghani@um.ac.ir.; Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, 9177948974, Mashhad, Iran. dehghani@um.ac.ir.

Publikováno v: Scientific reports [Sci Rep] 2022 Mar 01; Vol. 12 (1), pp. 3390. Date of Electronic Publication: 2022 Mar 01.

Child Neurology: RNA Sequencing for the Diagnosis of Lissencephaly.

Autor: Qashqari H; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada., Ramani A; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada., Gonorazky H; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada., Amburgey K; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada., Ghahramani Seno MM; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada., Brudno M; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada., Naumenko S; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada., Das S; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada., Dowling JJ; From the Division of Neurology, Department of Pediatrics (H.Q., H.G., K.A., J.J.D.), Centre for Computational Medicine (A.R., M.B.), and Program of Genetic and Genome Biology (H.G., K.A., M.M.G.S., M.B., J.J.D.), the Hospital for Sick Children, and Department of Pediatrics (J.J.D.), Department of Molecular Genetics (J.J.D.), and Research Department of Computer Science (M.B.), University of Toronto, Canada; Department of Biostatistics (S.N.), Harvard Chan School of Public Health, Boston, MA; Department of Human Genetics (S.D.), University of Chicago, IL; and Techna Institute (M.B.), University Health Network, Toronto, Canada. James.Dowling@sickkids.ca.

Publikováno v: Neurology [Neurology] 2021 Sep 20; Vol. 97 (12), pp. e1253-e1256. Date of Electronic Publication: 2021 Sep 20.

CRISPR/dCas9-mediated transposition with specificity and efficiency of site-directed genomic insertions.

Autor: Goshayeshi L; Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.; Stem Cell Biology and Regenerative Medicine Research Group, Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran., Yousefi Taemeh S; Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.; Stem Cell Biology and Regenerative Medicine Research Group, Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran., Dehdilani N; Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.; Stem Cell Biology and Regenerative Medicine Research Group, Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran., Nasiri M; Recombinant Proteins Research Group, Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran.; Department of Animal Science, Ferdowsi University of Mashhad, Mashhad, Iran., Ghahramani Seno MM; Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.; Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran., Dehghani H; Division of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.; Stem Cell Biology and Regenerative Medicine Research Group, Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran.; Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Feb; Vol. 35 (2), pp. e21359.

Expression Analysis of MALAT1, GAS5, SRA, and NEAT1 lncRNAs in Breast Cancer Tissues from Young Women and Women over 45 Years of Age.

Autor: Arshi A; Young Researchers and Elite Club, Najafabad Branch, Islamic Azad University, Najafabad, Iran., Sharifi FS; Biotechnology Research Center, School of Basic Sciences, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran., Khorramian Ghahfarokhi M; Division of Biotechnology, Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran., Faghih Z; Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Doosti A; Biotechnology Research Center, School of Basic Sciences, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran., Ostovari S; Department of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran., Mahmoudi Maymand E; Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Ghahramani Seno MM; Division of Biotechnology, Department of Pathobiology and Department of Basic Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address: mgseno@um.ac.ir.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2018 Sep 07; Vol. 12, pp. 751-757. Date of Electronic Publication: 2018 Jul 31.