Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Ghahhari, Nastaran"'
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Akademický článek
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2
Cooperative interaction between ERα and ZEB1 in breast cancer mediates global reprogramming of ERα signaling towards a metastatic phenotype during early EMT
Autor: Mohammadi Ghahhari, Nastaran
Metastasis is one of the major causes of endocrine resistance and mortality in breast cancer patients. The epithelial to mesenchymal transition (EMT) enables the metastatic spread of cancer cells. EMT-promoting transcription factors determine a conti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3be4f5b19291e0ac285cd916d9d1b8b
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3
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Autor: Joshi, Abhinav, Dai, Li, Liu, Yanxin, Lee, Jungsoon, Ghahhari, Nastaran Mohammadi, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa M., Lyons, Gaelyn C., Bernasconi, Lilia, Tsai, Francis T. F., Agard, David A., Neckers, Len, Picard, Didier
Publikováno v: BMC Biology
BMC Biology, Vol 18, Iss 1, Pp 1-23 (2020)
BMC Biology, Vol. 18, No 10 (2020)
Background The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitocho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0b1cfd4731c77edaf19067c23e184a9c
http://europepmc.org/articles/PMC6986101
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Additional file 2 of The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Autor: Abhinav Joshi, Dai, Li, Yanxin Liu, Jungsoon Lee, Ghahhari, Nastaran, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa, Gaelyn Lyons, Bernasconi, Lilia, Tsai, Francis, Agard, David, Neckers, Len, Picard, Didier
Additional file 2: Figure S2. Carbon flux and total quantitation of target metabolites. (a) Schematic metabolic map showing the flow and distribution of 13C atoms in metabolites of the TCA cycle when cells consume 13C-Gln. Note that most of these met
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5
Additional file 12 of The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Autor: Abhinav Joshi, Dai, Li, Yanxin Liu, Jungsoon Lee, Ghahhari, Nastaran, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa, Gaelyn Lyons, Bernasconi, Lilia, Tsai, Francis, Agard, David, Neckers, Len, Picard, Didier
Additional file 12: Figure S5. An extension of Figure 5 showing TRAP1-GST pulldown MS strategy and analysis, and a control experiment for mitochondrial lysis conditions. (a) TRAP1-GST pulldown strategy. (b) Venn diagram of the proteins identified by
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6
Additional file 6 of The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Autor: Abhinav Joshi, Dai, Li, Yanxin Liu, Jungsoon Lee, Ghahhari, Nastaran, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa, Gaelyn Lyons, Bernasconi, Lilia, Tsai, Francis, Agard, David, Neckers, Len, Picard, Didier
Additional file 6: Figure S4. Analysis of the whole cell proteome and TRAP1-associated proteins. (a) Control immunoblot performed to check TRAP1 WT and mutant expression in the KO cells used for the IP-MS experiments. (b, c) Comparative relative abun
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7
Additional file 5 of The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
Autor: Abhinav Joshi, Dai, Li, Yanxin Liu, Jungsoon Lee, Ghahhari, Nastaran, Segala, Gregory, Beebe, Kristin, Jenkins, Lisa, Gaelyn Lyons, Bernasconi, Lilia, Tsai, Francis, Agard, David, Neckers, Len, Picard, Didier
Additional file 5: Figure S3. TRAP1 truncation and point mutants. (a) Schematic representation of the constructs for expression of mitochondrially targeted TRAP1 and EGFP. (b) Fluorescence micrographs showing proper targeting of mitoEGFP to mitochond
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9
Akademický článek
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10
Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients
Autor: Piryaei, Mohammad, Ghaderian, Sayyed Mohammad Hossein, Vakili, Hossein, Zaimkohan, Hooshang, Mohammadi Ghahhari, Nastaran, Mafi Golchin, Maryam
Publikováno v: International Journal of Molecular and Cellular Medicine
Although genetic variants that affect susceptibility to coronary artery disease (CAD) have been greatly known, a number of these single nucleotide polymorphisms (SNPs) remain to be analyzed in populations with different ethnicities. CAD is influenced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79f468685c3734a09586659345a8bda4
http://europepmc.org/articles/PMC4644527
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