Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.

Autor: Green AC; Weston Park Cancer Centre and Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK., Marttila P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Kiweler N; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Chalkiadaki C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Cookson V; Weston Park Cancer Centre and Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK., Lesur A; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Eiden K; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Bernardin F; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Vallin KSA; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.; RISE Research Institutes of Sweden, Södertälje, Sweden., Borhade S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.; RedGlead Discover, Lund, Sweden., Long M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Ghahe EK; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark., Jiménez-Alonso JJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.; Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain., Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Loseva O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Mortusewicz O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Meyers M; Faculty of Science, Technology and Medicine, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Viry E; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Johansson AI; Swedish Metabolomics Centre, Department of Plant Physiology, Umeå University, Umeå, Sweden., Hodek O; Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden., Homan E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Bonagas N; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Ramos L; Weston Park Cancer Centre and Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK., Sandberg L; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Frödin M; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark., Moussay E; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Slipicevic A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.; One-carbon Therapeutics AB, Stockholm, Sweden., Letellier E; Faculty of Science, Technology and Medicine, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Paggetti J; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Sørensen CS; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark., Helleday T; Weston Park Cancer Centre and Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK. thomas.helleday@scilifelab.se.; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. thomas.helleday@scilifelab.se., Henriksson M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. martin.henriksson@scilifelab.se., Meiser J; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg. Johannes.Meiser@lih.lu.

Publikováno v: Nature metabolism [Nat Metab] 2023 Apr; Vol. 5 (4), pp. 642-659. Date of Electronic Publication: 2023 Apr 03.