Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ghadamali Khodarahmi"'
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38365- (2024)
In this study novel triazine-tyrosine hybrids containing thiazole or pyridine fragments were introduced as anti- Multiple Sclerosis agents. The compounds were designed according to the structure of the Sphingosine-1-phosphate receptor subtype 1 (S1P1
Externí odkaz:
https://doaj.org/article/5fee9aba57d14c0fbcbe5d4f7bbd793f
Identification of new small molecules as dual FoxM1 and Hsp70 inhibitors using computational methods
Autor:
Zahra Alimardan, Maryam Abbasi, Ghadamali Khodarahmi, Khosrow Kashfi, Farshid Hasanzadeh, Aghaei Mahmud
Publikováno v:
Research in Pharmaceutical Sciences, Vol 17, Iss 6, Pp 635-656 (2022)
Background and purpose: FoxM1 and Hsp70 proteins are highly expressed in many cancers. Thus, their inhibition serves as Bonafede targets in cancer treatment. Experimental approach: FDI-6, an inhibitor of FoxM1, was selected as a template, and based o
Externí odkaz:
https://doaj.org/article/6628ce09445c48478e76468f2adbf31c
Autor:
Fateme Azimi, Homa Azizian, Mohammad Najafi, Ghadamali Khodarahmi, Lotfollah Saghaei, Motahareh Hassanzadeh, Jahan B. Ghasemi, Mohammad Ali Faramarzi, Bagher Larijani, Farshid Hassanzadeh, Mohammad Mahdavi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract In this work, new derivatives of biphenyl pyrazole-benzofuran hybrids were designed, synthesized and evaluated in vitro through enzymatic assay for inhibitory effect against α-glucosidase activity. Newly identified inhibitors were found to
Externí odkaz:
https://doaj.org/article/f66407a315e44ced928a38ae344fb9e1
Publikováno v:
Research in Pharmaceutical Sciences, Vol 16, Iss 5, Pp 455-463 (2021)
Background and purpose: Pyridopyrimidine and its derivatives have a variety of chemical and biological significances. Thiazole-containing compounds have also been reported to have a wide range of biological activities. Due to the valuable cytotoxic e
Externí odkaz:
https://doaj.org/article/26403b5fe7cd46b6a3060519fb15b114
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 5, Pp 454-462 (2020)
Background and purpose: Oxadiazole-derived compounds have been shown to have a wide range of pharmacological activities. 2, 5-Disubstituted 1, 3, 4-oxadiazole derivatives have occupied a specific place in the design of anti-proliferative agents. In t
Externí odkaz:
https://doaj.org/article/33ac2dbab7f841ffbdf23ba0cd338f3f
Publikováno v:
Research in Pharmaceutical Sciences, Vol 14, Iss 3, Pp 247-254 (2019)
Quinazolinone and benzimidazole are both fused heterocyclic compounds which have shown valuable biological properties including cytotoxic, antibacterial, and antifungal activities. In this study, a series of novel quinazolinone derivatives substitute
Externí odkaz:
https://doaj.org/article/6eeda0a337334eeaa46882d6ff40da3b
Publikováno v:
Journal of Research in Medical Sciences, Vol 27, Iss 1, Pp 68-68 (2022)
Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural
Externí odkaz:
https://doaj.org/article/d81f3bd87bf44e44ba069d19b543d321
Publikováno v:
Research in Pharmaceutical Sciences, Vol 13, Iss 2, Pp 168-176 (2018)
A series of novel sorafenib analogues containing a quinoxalinedione ring and amide linker were synthesized. A total of 9 novel compounds in 6 synthetic steps were synthesized. Briefly, the amino group of p-aminophenol was first protected which then f
Externí odkaz:
https://doaj.org/article/4a93a176926c4954a7c016431af6c542
Autor:
Sedighe Sadeghian-Rizi, Ghadamali Khodarahmi, Amirhossein Sakhteman, Ali Jahanian-Najafabadi, Mahboubeh Rostami, Mahmoud Mirzaei, Farshid Hassanzadeh
Publikováno v:
Research in Pharmaceutical Sciences, Vol 13, Iss 1, Pp 82-92 (2018)
Diaryl urea derivatives have exhibited a broad spectrum of biochemical effects and pharmaceutical applications. Several diaryl urea derivatives such as sorafenib, regorafenib, linifanib, and tivozanib and lenvatinib are in clinical trial or clinical
Externí odkaz:
https://doaj.org/article/1a616a658a984cc0b3cbf7310b9f4c4c
Synthesis and cytotoxic evaluation of novel quinazolinone derivatives as potential anticancer agents
Autor:
Safoora Poorirani, Sedighe Sadeghian-Rizi, Ghadamali Khodarahmi, Marzieh Rahmani Khajouei, Farshid Hassanzadeh
Publikováno v:
Research in Pharmaceutical Sciences, Vol 13, Iss 5, Pp 450-459 (2018)
Nitrogen-rich heterocyclic compounds represent a unique class of chemicals with especial properties and have been modified to design novel pharmaceutically active compounds. In this study, a series of novel quinazolinone derivatives with substituted
Externí odkaz:
https://doaj.org/article/4faa5471857549a8940794c6ab2a6fc8