Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ghadah Alameer"'
Autor:
Peter Laslo, David G. Kent, Edwin Chen, Joanna Baxter, Jeanne F Rivera, Hershna Patel, Emma L Burman, Sally A Boxall, Brian R. Jackson, Ann Mullally, Grace Boyd, Rachael Smyth, Ghadah Alameer, April Joy Baral, Anthony R. Green, Fatima Nadat
Publikováno v:
Blood Adv
Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALRdel52) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c88bd78a01d6c569428b7041878c47a
https://www.repository.cam.ac.uk/handle/1810/319699
https://www.repository.cam.ac.uk/handle/1810/319699
Autor:
Sally A Boxall, Rachael Smyth, Fatima Nadat, Edwin Chen, Ann Mullally, Jeanne F Rivera, Brian R. Jackson, Ghadah Alameer, April Joy Baral, Emma L Burman
Publikováno v:
Blood. 134:312-312
Recurrent mutations in the ER chaperone calreticulin (CALR) are found in ~30% of MPNs. All known CALR mutations result in a +1-frameshift of the CALR reading frame that retains the N-domain and P-arm of wild-type CALR and generates a novel mutant-spe