Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Ghada Alsaleh"'
Autor:
Veronique Bernier, Ghada Alsaleh, Camille Point, Benjamin Wacquier, Jean-Pol Lanquart, Gwenolé Loas, Matthieu Hein
Publikováno v:
Brain Sciences, Vol 14, Iss 9, p 850 (2024)
Major depressive disorder (MDD) is associated with inflammation and a high level of comorbidities. Atypical depression (AD) is a MDD subtype based on DSM criteria, that could have specific underlying biological mechanisms. AD is associated with eleva
Externí odkaz:
https://doaj.org/article/f5e1be0618d94b75ac1de3eff751c258
Autor:
Dingxi Zhou, Mariana Borsa, Daniel J. Puleston, Susanne Zellner, Jesusa Capera, Sharon Sanderson, Martina Schifferer, Svenja S. Hester, Xin Ge, Roman Fischer, Luke Jostins, Christian Behrends, Ghada Alsaleh, Anna Katharina Simon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Autophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as
Externí odkaz:
https://doaj.org/article/1ccb857c105547c5b33bd8c47532fb9e
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Ageing is the biggest risk factor for the development of multiple chronic diseases as well as increased infection susceptibility and severity of diseases such as influenza and COVID-19. This increased disease risk is linked to changes in immune funct
Externí odkaz:
https://doaj.org/article/8b48fdc618c94f10a8bfbc1bff10bed9
Autor:
Valentina Pucino, Meriam Nefla, Vincent Gauthier, Ghada Alsaleh, Sally A. Clayton, Jennifer Marshall, Andrew Filer, Andy R. Clark, Karim Raza, Christopher D. Buckley
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe synovial membrane is the main site of inflammation in rheumatoid arthritis (RA). Here several subsets of fibroblasts and macrophages, with distinct effector functions, have been recently identified. The RA synovium is hypoxic and acid
Externí odkaz:
https://doaj.org/article/cf1c330f4be2412981ed289d70a14e95
Autor:
Vincent Gauthier, Maria Kyriazi, Meriam Nefla, Valentina Pucino, Karim Raza, Christopher D. Buckley, Ghada Alsaleh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts maintain micro-environmental homeostasis and create tissue niches by
Externí odkaz:
https://doaj.org/article/37284b22939d444e8a3070cf207582b2
Autor:
Ghada Alsaleh, Isabel Panse, Leo Swadling, Hanlin Zhang, Felix Clemens Richter, Alain Meyer, Janet Lord, Eleanor Barnes, Paul Klenerman, Christopher Green, Anna Katharina Simon
Publikováno v:
eLife, Vol 9 (2020)
Vaccines are powerful tools to develop immune memory to infectious diseases and prevent excess mortality. In older adults, however vaccines are generally less efficacious and the molecular mechanisms that underpin this remain largely unknown. Autopha
Externí odkaz:
https://doaj.org/article/286d449e7c4a45858c0bb7baa6a2e133
Autor:
Alain Meyer, Gilles Laverny, Livio Bernardi, Anne Laure Charles, Ghada Alsaleh, Julien Pottecher, Jean Sibilia, Bernard Geny
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Inflammation is a cellular and molecular response to infection and/or tissues injury. While a suited inflammatory response in intensity and time allows for killing pathogens, clearing necrotic tissue, and healing injury; an excessive inflammatory res
Externí odkaz:
https://doaj.org/article/b35d06021257451da6059528c4f92509
Autor:
Cindy Barnig, Ghada Alsaleh, Nicolas Jung, Doulaye Dembélé, Nicodème Paul, Anh Poirot, Béatrice Uring-Lambert, Philippe Georgel, Fréderic de Blay, Seiamak Bahram
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141740 (2015)
Eosinophils are leukocytes that are released into the peripheral blood in a phenotypically mature state and are capable of being recruited into tissues in response to appropriate stimuli. Eosinophils, traditionally considered cytotoxic effector cells
Externí odkaz:
https://doaj.org/article/eae73dc704d34dbdb90bfc65de53b964
Autor:
Ghada Alsaleh, Antoine François, Lucas Philippe, Ya-Zhuo Gong, Seiamak Bahram, Semih Cetin, Sébastien Pfeffer, Jacques-Eric Gottenberg, Dominique Wachsmann, Philippe Georgel, Jean Sibilia
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111266 (2014)
We evaluated micro (mi) RNA-mediated regulation of BAFF expression in fibroblasts using two concomitant models: (i) synovial fibroblasts (FLS) isolated from healthy controls (N) or Rheumatoid Arthritis (RA) patients; (ii) human dermal fibroblasts (HD
Externí odkaz:
https://doaj.org/article/ba75f109613e41e09b6c2b5e725bbe5a
Autor:
Eleonore Ostermann, Lee Tuddenham, Cecile Macquin, Ghada Alsaleh, Julie Schreiber-Becker, Melanie Tanguy, Seiamak Bahram, Sebastien Pfeffer, Philippe Georgel
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43744 (2012)
Regulation of gene expression by microRNAs (miRNAs) is now considered as an essential mechanism for cell development and homeostasis. Indeed, numerous studies have reported that modulating their expression, maturation, or activity can affect cell sur
Externí odkaz:
https://doaj.org/article/54280482a03249e3908c3ed8db9706e8