Výsledky vyhledávání

[Clinical phase II-evaluation of neoadjuvant, cytostatic combination chemotherapy with docetaxel and epidoxorubicin in female breast cancer patients (T1-4, N0-2, M0)]

Autor: Wenzel C, Schmidinger M, Gj, Locker, Taucher S, Michael Gnant, Jakesz R, Gg, Steger

Publikováno v: Europe PubMed Central

Preoperative (neo-adjuvant) chemotherapy is very effective in downstaging primary tumors and moreover is able to prevent advancing metastatic growth early in the course of the disease.We report on 38 patients with a median age of 54 years (range, 33-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7a3aa2048155e22c16675e35a70723a2
https://pubmed.ncbi.nlm.nih.gov/10586489

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Negative chronotropic effects of fentanyl attenuate beneficial effects of dobutamine on oxygen metabolism: hemodynamic and pharmacokinetic interactions

Autor: Gj, Locker, Robert Mader, Rizovski B, Knapp S, Domanovits H, Muellner M, Hoeller C, Gg, Steger, Sterz F, Freissmuth M, Frass M, An, Laggner

Publikováno v: Europe PubMed Central

Opioids are well known to cause cardiovascular depression. The aim of the present investigation was to determine whether an interaction of opioid derivatives with catecholamines might be involved in these hemodynamic alterations. Six comatose patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::689127057f1237e7219e7d8ea9c931ae
https://pubmed.ncbi.nlm.nih.gov/10381758

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Interstitial methotrexate kinetics in primary breast cancer lesions

Autor: Müller M, Brunner M, Schmid R, Robert Mader, Bockenheimer J, Gg, Steger, Steiner B, Hg, Eichler, Blöchl-Daum B

Publikováno v: Europe PubMed Central

The transfer of cytotoxic agents across the tumor endothelium into the interstitial tumor space is considered a critical step in clinical resistance of solid tumors to antineoplastic chemotherapy. However, experimental data on drug transfer from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::508800a300d83136e18bf26356d6dd5f
https://pubmed.ncbi.nlm.nih.gov/9679959

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Modulation of 5-fluorouracil resistance in human colon tumor cell lines by azidothymidine

Autor: Findenig G, Robert Mader, Fritzer-Szekeres M, Gg, Steger, Jaeger W, Szekeres T

Publikováno v: Europe PubMed Central
Scopus-Elsevier

5-fluorouracil (5-FU), an inhibitor of thymidylate synthase (EC 2.1.1.45), is clinically used in the treatment of several solid tumors, including colorectal, head and neck, gastric, and pancreatic cancer. The drug effectively inhibits deoxynucleoside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4539c76f9b7f6c3c1587b0e22ace4327
https://pubmed.ncbi.nlm.nih.gov/8884811

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Stereospecific pharmacokinetics of rac-5-methyltetrahydrofolic acid in patients with advanced colorectal cancer

Autor: Robert Mader, Gg, Steger, Rizovski B, Mp, Djavanmard, Scheithauer W, Jakesz R, Rainer H

Publikováno v: Europe PubMed Central

1. The pharmacokinetics and toxicity of racemic 5-methyltetrahydrofolic (rac-5-MTHF) acid after i.v. infusion were investigated in 18 patients with advanced colorectal cancer. Doses of 100-600 mg rac-5-MTHF/m2 were administered over 2 h together with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3589663defaae97c3a1a29e06ec8f607
https://pubmed.ncbi.nlm.nih.gov/8527281

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The effects of granulocyte-macrophage colony-stimulating factor on tumour-infiltrating lymphocytes from renal cell carcinoma

Autor: JB deKernion, Randhir Kaboo, Arie S. Belldegrun, Robert A. Figlin, GG Steger

Publikováno v: British Journal of Cancer

It has been shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) can induce specific and non-specific anti-tumour cytotoxicity and also stimulates the proliferation and function of peripheral lymphocytes and thymocytes. GM-CSF and int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b289a8a103c5fe6b01b9109ec5cae526
https://pubmed.ncbi.nlm.nih.gov/7599037

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Long-term remission in a patient with erythroleukemia following interferon-alpha treatment

Autor: Gg, Steger, Dittrich C, Chott A, Kurt Derfler, Jd, Schwarzmeier

Publikováno v: Europe PubMed Central

A patient in second relapse of acute erythroleukemia (AEL) was treated with 10 MU of recombinant interferon (IFN)-alpha subcutaneously for 24 days after he had failed standard chemotherapy. Besides fever up to 38.9 degrees C and a transient raise in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8290b1729b659ab13e838c13812ed35d
https://pubmed.ncbi.nlm.nih.gov/2754435

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