Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats

Autor: Jv, Medeiros, Gg, Gadelha, Sj, Lima, Ja, Garcia, Pm, Soares, Aa, Santos, Gerly Anne de Castro Brito, Ra, Ribeiro, Mh, Souza

Publikováno v: Europe PubMed Central

Sildenafil is a selective inhibitor of cGMP-specific phosphodiesterase. Sildenafil, acting via NO-dependent mechanisms, prevents indomethacin-induced gastropathy. Activation of ATP-sensitive potassium channels (K(ATP)) is involved in gastric defence.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::efe0d5093860163d7f9f9fc8e7bd0d07
https://pubmed.ncbi.nlm.nih.gov/18084311

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