Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: evidence for reduced toxicity and enhanced antitumor activity in mice

Autor: Dl, Gu, Am, Gonzalez, Ma, Printz, Doukas J, Ying W, D'Andrea M, Dk, Hoganson, Dt, Curiel, Jt, Douglas, Ba, Sosnowski, Andrew Baird, Sl, Aukerman, Gf, Pierce

Publikováno v: Europe PubMed Central

Adenovirus (Ad) have been used as vectors to deliver genes to a wide variety of tissues. Despite achieving high expression levels in vivo, Ad vectors display normal tissue toxicity, transient expression, and antivector immune responses that limit the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::291ba106e8e0793bc5b9c32d4b122c7a
https://pubmed.ncbi.nlm.nih.gov/10363982

Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia

Autor: Dimitry Danilenko, Bd, Ring, Yanagihara D, Benson W, Wiemann B, Co, Starnes, Gf, Pierce

Publikováno v: Europe PubMed Central

The growth and development of hair follicles is influenced by a number of different growth factors and cytokines, particularly members of the fibroblast growth factor (FGF) family. Keratinocyte growth factor (KGF or FGF-7) is a recently identified 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::72eea989473df97f4b204523f64a07f6
https://pubmed.ncbi.nlm.nih.gov/7604876

A laboratory medicine residency training program that includes clinical consultation and research

Autor: Eric Spitzer, Gf, Pierce, Jm, Mcdonald

Publikováno v: Europe PubMed Central

We describe a laboratory medicine residency training program that includes ongoing interaction with both clinical laboratories and clinical services as well as significant research experience. Laboratory medicine residents serve as on-call consultant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ca27107e9c110df274207beebf2d5374
http://europepmc.org/abstract/med/2322095

International Society on Thrombosis and Haemostasis Clinical Practice Guideline for Treatment of Congenital Haemophilia-A Critical Appraisal.

Autor: Albisetti M; University Children's Hospital, Zurich, Switzerland., Ardila J; Clínica Imbanaco Quirón Salud Hemophilia Center, IPS Especializada Coagulopathies Program, Universidad del Valle School of Public Health, Cali, Colombia., Astermark J; Department of Translational Medicine, Lund University, Lund, Sweden.; Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Malmö, Sweden., Blatny J; Department of Paediatric Haematology and Biochemistry, University Hospital Brno and Masaryk University, Brno, Czech Republic and Hospital Bory, Bratislava, Slovakia., Carcao M; Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Chowdary P; Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London, UK., Connell NT; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Crato M; European Haemopilia Consortium, Brussels, Belgium., Dargaud Y; French Reference Center for Hemophilia, Clinical Haemostasis Unit, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France.; Universite Claude Bernard Lyon 1 (UCLB), Lyon, France., d'Oiron R; Centre de Référence de l'Hémophilie et des Maladies Hémorragiques Rares, Hôpital Bicêtre APHP, and HITh, UMR_S1176, INSERM, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Dunn AL; Nationwide Children's Hospital Division of Hematology, Oncology and Bone Marrow Transplant, Columbus, Ohio, USA., Escobar MA; University of Texas Health Science Center at Houston, Houston, Texas, USA., Ettingshausen CE; HZRM-Haemophilie Zentrum Rhein-Main, Frankfurt, Germany., Fischer K; Center for Benign Haematology, Thrombosis and Haemostasis Van Creveldkliniek, University Medical Center Utrecht, Utrecht, The Netherlands., Gouider E; Service d'hématologie biologique Hemophilia Center Aziza Othmana, University Tunis El Manar, Tunis, Tunisia., Harroche A; Service d'Hématologie Clinique Centre de Traitement de l'Hémophilie, Hôpital Necker Enfants Malades, AP-HP, Paris, France., Hermans C; Division of Adult Haematology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Brussels, Belgium., Jimenez-Yuste V; Hematology Department, Hospital Universitario La Paz-IdiPaz, Autonoma University, Madrid, Spain., Kaczmarek R; Indiana University School of Medicine, Indianapolis, Indiana, USA., Kenet G; The Israeli National Hemophilia Center and Thrombosis Research Institute, Sheba Medical Center, Tel Hashomer & Tel Aviv University, Ramat Gan, Israel., Khoo L; Haematology Department, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Klamroth R; Department for Internal Medicine and Vascular Medicine, Haemophilia Treatment Center, Vivantes Hospital im Friedrichshain, Berlin, Germany., Langer F; Department of Hematology and Oncology, University Medical Center Eppendorf, Hamburg, Germany., Lillicrap D; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada., Mahlangu J; Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, Gauteng, South Africa., Male C; Department of Paediatrics, Medical University of Vienna, Vienna, Austria., Mancuso ME; Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Matsushita T; Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan., Meunier S; Hospices Civils de Lyon- French Reference Center for Hemophilia, Clinical Haemostasis Unit Lyon, Louis Pradel Hospital, Bron, France., Miesbach W; Medical Clinic 2, University Hospital Frankfurt, Frankfurt, Germany., Nolan B; Children's Health Ireland at Crumlin, Dublin, Ireland., Oldenburg J; Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Medical Faculty, University of Bonn, Bonn, Germany., O'Mahony B; Irish Haemophilia Society, Dublin, Ireland., Ozelo M; Department of Internal Medicine, School of Medical Sciences, Hemocentro UNICAMP, University of Campinas, Campinas, SP, Brazil., Pierce GF; World Federation of Hemophilia, Montreal, Quebec, Canada., Ramos G; Reference Laboratory in Haemostasis and Hematology, National University, Bogotà, Colombia., Recht M; Yale University, New Haven, Connecticut, USA.; National Bleeding Disorders Foundation, New York, New York, USA., Romero-Lux O; European Haemopilia Consortium, Brussels, Belgium., Rotellini D; National Bleeding Disorders Foundation, New York, New York, USA., Santoro RC; Centre for Hemorrhagic and Thrombotic Disorders, Azienda Ospedaliera-Universitaria Renato Dulbecco, Catanzaro, Italy., Singleton TC; OchsnerClinic Foundation, Pediatric Hematology and Bone Marrow Transplant, New Orleans, Louisiana, USA., Skinner MW; Institute for Policy Development Ltd, Washington, District of Columbia, USA.; McMaster University, Hamilton, Ontario, Canada., Srivastava A; Haematology Research Unit, St. Johns Research Institute and Department of Clinical Haematology, St. John's Medical College Hospital, Bengaluru, India., Susen S; Hemostasis and Transfusion Department, University of Lille, Lille University Hospital, Lille, France., Talks K; Newcastle Haemophilia Centre, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK., Tran H; The Alfred Hospital, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia., Valentino LA; Hemophilia and Thrombophilia Center, Rush University Medical Center, Chicago, Illinois, USA., Windyga J; Department of Haemostasis Disorders and Internal Medicine, Laboratory of Haemostasis and Metabolic Diseases, Institute of Haematology and Transfusion Medicine, Warsaw, Poland., Yang R; Thrombosis and Hemostasis Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.

Second gene therapy for hemophilia B approved: More answers or questions?

Autor: Kaczmarek R; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: rkaczmar@iu.edu., Pierce GF; World Federation of Hemophilia, Montreal, QC, Canada. Electronic address: gpierce@wfh.org.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Nov 29. Date of Electronic Publication: 2024 Nov 29.