The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

Autor: Antinori, Spinello, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Van Coillie, Julie, Pongracz, Tamas, Rahmöller, Johann, Chen, Hung-Jen, Geyer, Chiara Elisabeth, Buhre, Jana Sophia, Šuštić, Tonći, van Osch, Thijs Luc Junior, Steenhuis, Maurice, Hoepel, Willianne, Wang, Wenjun, Lixenfeld, Anne Sophie, Nouta, Jan, Keijzer, Sofie, Linty, Federica, Visser, Remco, Larsen, Mads Delbo, Martin, Emily Lara, Künsting, Inga, Lehrian, Selina, von Kopylow, Vera, Kern, Carsten, Lunding, Hanna Bele, de Winther, Menno, Rispens, Theo, Graf, Tobias, Slim, Marleen Adriana, Minnaar, René Peter, Bomers, Marije Kristianne, Sikkens, Jonne Jochum, van der Schoot, C. Ellen, den Dunnen, Jeroen, Wuhrer, Manfred, Ehlers, Marc, Vidarsson, Gestur

Publikováno v: In eBioMedicine January 2023 87

Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation

Autor: He, Minghui, Saeed, Mezida B., Record, Julien, Keszei, Marton, Gonçalves Pinho, Lia, Vasconcelos-Fontes, Larissa, D’Aulerio, Roberta, Vieira, Rhaissa, Oliveira, Mariana M.S., Geyer, Chiara, Bohaumilitzky, Lena, Thiemann, Meike, Deordieva, Ekaterina, Buedts, Lieselot, Matias Lopes, Joao Pedro, Pershin, Dmitry, Hammarström, Lennart, Xia, Yu, Zhao, Xiaodong, Cunningham-Rundles, Charlotte, Thrasher, Adrian J., Burns, Siobhan O., Cotta-de-Almeida, Vinicius, Liu, Chaohong, Shcherbina, Anna, Vandenberghe, Peter, Westerberg, Lisa S.

Publikováno v: In The Journal of Allergy and Clinical Immunology March 2022 149(3):1069-1084

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Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Autor: Larsen, Mads Delbo, de Graaf, Erik L., Sonneveld, Myrthe E., Plomp, H. Rosina, Nouta, Jan, Hoepel, Willianne, Chen, Hung-Jen, Linty, Federica, Visser, Remco, Brinkhaus, Maximilian, Šuštić, Tonći, de Taeye, Steven W., Bentlage, Arthur E. H., Toivonen, Suvi, Koeleman, Carolien A. M., Sainio, Susanna, Kootstra, Neeltje A., Brouwer, Philip J. M., Geyer, Chiara Elisabeth, Derksen, Ninotska I. L., Wolbink, Gertjan, de Winther, Menno, Sanders, Rogier W., van Gils, Marit J., de Bruin, Sanne, Vlaar, Alexander P. J., Rispens, Theo, den Dunnen, Jeroen, Zaaijer, Hans L., Wuhrer, Manfred, van der Schoot, C. Ellen, Vidarsson, Gestur, Study group members AMC, Wiersinga, W. Joost, de Bree, Godelieve J., Geerlings, Suzanne E., Goorhuis, Bram, Grobusch, Martin P., Harris, Vanessa C., Hermans, Sabine M., Hovius, Joppe W. R., Nellen, Jeannine, van der Poll, Tom, Prins, Jan M., Stijnis, Cornelis S., van der Valk, Marc, van Vugt, Michele, Hollmann, Markus W., Preckel, Prof. dr. , Benedikt, Veelo, Denise P.

Publikováno v: Science, 371(6532):abc8378. American Association for the Advancement of Science
Science (New York, N.y.)
Science, 371(6532), 907-+. AMER ASSOC ADVANCEMENT SCIENCE
Science
Larsen, M D, de Graaf, E L, Sonneveld, M E, Plomp, H R, Nouta, J, Hoepel, W, Chen, H-J, Linty, F, Visser, R, Brinkhaus, M, Šuštić, T, de Taeye, S W, Bentlage, A E H, Toivonen, S, Koeleman, C A M, Sainio, S, Kootstra, N A, Brouwer, P J M, Geyer, C E, Derksen, N I L, Wolbink, G, de Winther, M, Sanders, R W, van Gils, M J, de Bruin, S, Vlaar, A P J, Rispens, T, den Dunnen, J, Zaaijer, H L, Wuhrer, M, Ellen van der Schoot, C, Vidarsson, G, Amsterdam UMC COVID-19 & Bugiani, M 2021, ' Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity ', Science, vol. 371, no. 6532, abc8378 . https://doi.org/10.1126/science.abc8378

A single sugar makes all the difference Antibodies are divided into several classes based on their nonvariable tail (Fc) domains. These regions interact with disparate immune cell receptors and complement proteins to help instruct distinct immune res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4588ae9863234ee73b2d592c7652a42b
https://doi.org/10.1126/science.abc8378

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