Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Geurt Schilders"'
Autor:
Geurt Schilders, Aswin Jansen, Juha Kotimaa, Cees van Kooten, Helma Rutjes, Mohamed R. Daha, Ngaisah Klar-Mohammad, Faikah Gueler
Publikováno v:
Molecular Immunology
Molecular Immunology, 76, 13-21
Molecular Immunology, 76, 13-21
Experimental mouse models have been extensively used to elucidate the role of the complement system in different diseases and injuries. Contribution of gender has revealed an intriguing gender specific difference; female mice often show protection ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97db082abaac5108cb009d6ca8d202ca
https://hdl.handle.net/1887/113671
https://hdl.handle.net/1887/113671
Autor:
Shimyn Slomovic, Geurt Schilders, Reinout Raijmakers, Ger J.M. Pruijn, Alfred W. Bronkhorst, Gadi Schuster, Raymond H.J. Staals, Albert J. R. Heck
Publikováno v:
EMBO Journal, 29, 2358-2367
EMBO Journal, 29, 14, pp. 2358-2367
EMBO Journal, 29, 14, pp. 2358-2367
Item does not contain fulltext The exosome is an exoribonuclease complex involved in the degradation and maturation of a wide variety of RNAs. The nine-subunit core of the eukaryotic exosome is catalytically inactive and may have an architectural fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77158524799e29cd4824a99d456ed79
https://hdl.handle.net/2066/83868
https://hdl.handle.net/2066/83868
Publikováno v:
Nucleic Acids Research, 35, 8, pp. 2564-2572
Nucleic Acids Research, 35, 2564-2572
Nucleic Acids Research
Nucleic Acids Research, 35, 2564-2572
Nucleic Acids Research
The exosome is a complex of 3'-5' exoribonucleases and RNA-binding proteins, which is involved in processing or degradation of different classes of RNA. Previously, the characterization of purified exosome complexes from yeast and human cells suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85620be05b7efb920ce73bce8770748c
https://doi.org/10.1093/nar/gkm082
https://doi.org/10.1093/nar/gkm082
Autor:
Juha P. Kotimaa, Maaike B. van Werkhoven, Joseph O'Flynn, Ngaisah Klar-Mohamad, Jan van Groningen, Geurt Schilders, Helma Rutjes, Mohamed R. Daha, Marc A. Seelen, Cees van Kooten
Publikováno v:
Journal of Immunological Methods, 419, 25-34. ELSEVIER SCIENCE BV
Journal of Immunological Methods, 419, 25-34
Journal of Immunological Methods, 419, 25-34
The complement system is an essential component of our innate immunity, both for the protection against infections and for proper handling of dying cells. However, the complement system can also contribute to tissue injury and inflammatory responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df7efd55037cb9056ba12c180df4856
https://hdl.handle.net/1887/101444
https://hdl.handle.net/1887/101444
Publikováno v:
Nucleic Acids Research, 33, 6795-6804
Nucleic Acids Research, 33, 21, pp. 6795-6804
Nucleic Acids Research
Nucleic Acids Research, 33, 21, pp. 6795-6804
Nucleic Acids Research
The exosome is a complex of 3 0 !5 0 exoribonucleases which is involved in many RNA metabolic processes. To regulate these functions distinct proteins are believed to recruit the exosome to specific substrate RNAs. Here, we demonstrate that M-phase p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ff57acf59bfae0bea80ac4542f934b
https://hdl.handle.net/2066/32691
https://hdl.handle.net/2066/32691
Autor:
Juha Kotimaa, N. Klar-Mohammad, Helma Rutjes, C. van Kooten, P. van der Pol, M. R. Daha, S. Leijtens, Geurt Schilders
Publikováno v:
Journal of Immunological Methods, 412, 14-23
There is a growing interest in the monitoring of complement activation, not only in clinical settings but also in experimental models. However, for rodents only a limited number of tools are available to assess complement activity and activation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36993b36453c052afb21a84bdf2d7ac2
https://hdl.handle.net/1887/103439
https://hdl.handle.net/1887/103439
Autor:
Juha Kotimaa, J. P. van Groningen, C. van Kooten, Joseph O'Flynn, Mohamed R. Daha, Geurt Schilders
Publikováno v:
Molecular Immunology, 56(3), 270-271
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4422abd2b0897f1021852f23d989c5
https://hdl.handle.net/1887/103409
https://hdl.handle.net/1887/103409
Autor:
Geurt, Schilders, Ger J M, Pruijn
Publikováno v:
Methods in enzymology. 448
A key component responsible for 3'- to 5'-RNA turnover in eukaryotic cells is the exosome, a multisubunit complex present in both the nucleus and cytoplasm of the cell. Here we describe several methods that can be applied to study the structure and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09221a9b916eabe238137f9ac6498894
https://pubmed.ncbi.nlm.nih.gov/19111178
https://pubmed.ncbi.nlm.nih.gov/19111178
Autor:
Ger J. M. Pruijn, Geurt Schilders
A key component responsible for 3′‐ to 5′‐RNA turnover in eukaryotic cells is the exosome, a multisubunit complex present in both the nucleus and cytoplasm of the cell. Here we describe several methods that can be applied to study the structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e72359fd647ec48bba3903c4a42644
https://doi.org/10.1016/s0076-6879(08)02611-6
https://doi.org/10.1016/s0076-6879(08)02611-6
Publikováno v:
Rna : a Publication of the Rna Society, 13, 1027-1035
Rna : a Publication of the Rna Society, 13, 7, pp. 1027-1035
Rna : a Publication of the Rna Society, 13, 7, pp. 1027-1035
The human exosome is a 3'-5' exoribonuclease complex that functions both in the nucleus and in the cytoplasm to either degrade or process RNA. Little is known yet about potential differences among core exosome complexes in these different cellular co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55b13dca2156711c185c6fc801fd599
https://doi.org/10.1261/rna.575107
https://doi.org/10.1261/rna.575107