Baseline epitope-specific IgE profiles are predictive of sustained unresponsiveness or high threshold 1-year post oral immunotherapy in the POISED trial.

Autor: Suprun M; Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY., Lee ASE; Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY., Getts R; Allergenis, Wynnewood, Pa., Peck S; Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY., Sindher SB; Division of Allergy and Immunology, Stanford School of Medicine, Stanford, Calif., Nadeau KC; Division of Allergy and Immunology, Stanford School of Medicine, Stanford, Calif., Chinthrajah RS; Division of Allergy and Immunology, Stanford School of Medicine, Stanford, Calif., Galli SJ; Department of Pathology, Stanford School of Medicine, Stanford, Calif; Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, Calif., Sampson HA; Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: hugh.sampson@mssm.edu.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Nov 05. Date of Electronic Publication: 2024 Nov 05.

Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors.

Autor: Vaziri-Gohar A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Cassel J; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Mohammed FS; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Zarei M; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA., Hue JJ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA., Hajihassani O; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Graor HJ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Srikanth YVV; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Karim SA; Cancer Research UK Beatson Institute, Glasgow, UK., Abbas A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Prendergast E; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Chen V; Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA., Katayama ES; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Dukleska K; Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Khokhar I; Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Andren A; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA., Zhang L; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA., Wu C; Department of Radiology, Case Western Reserve University, Cleveland, OH, USA., Erokwu B; Department of Radiology, Case Western Reserve University, Cleveland, OH, USA., Flask CA; Deptartments of Radiology, Biomedical Engineering, and Pediatrics, Case Western Reserve University, Cleveland, OH, USA., Zarei M; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA., Wang R; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Rothermel LD; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA., Romani AMP; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA., Bowers J; Code Biotherapeutics Inc, Hatfield, PA, USA., Getts R; Code Biotherapeutics Inc, Hatfield, PA, USA., Tatsuoka C; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Morton JP; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Bederman I; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Brunengraber H; Department of Nutrition and Biochemistry, Case Western Reserve University, Cleveland, OH, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA., Salvino JM; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA., Brody JR; Brenden Colson Center for Pancreatic Care; Departments of Surgery and Cell, Developmental & Cancer Biology; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Winter JM; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. jordan.winter@UHhospitals.org.; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA. jordan.winter@UHhospitals.org.

Publikováno v: Nature cancer [Nat Cancer] 2022 Jul; Vol. 3 (7), pp. 852-865. Date of Electronic Publication: 2022 Jun 09.

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

Autor: Joseph M. Salvino, Mohammed Fs, Khokhar I, Katerina Dukleska, Jordan M. Winter, Getts R, Brody, Prendergast E, Ilya Bederman, Hajhassani O, Browers J, Mahsa Zarei, Ali Vaziri-Gohar, Atheir I. Abbas, Joel Cassel, Jonathan J. Hue, Graor Hj, Rothermel Ld, Henri Brunengraber, Rui Wang, Chen

Pancreatic cancer cells alter their metabolism to survive cancer-associated stress (1-4). For example, cancer cells must adapt to steep nutrient gradients that characterize the natural tumor microenvironment (TME) (5-7). In the absence of adaptive st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64a609fef48b62d0bdc1530daadb2388
https://doi.org/10.1101/2020.11.19.390633

Predicting probability of tolerating discrete amounts of peanut protein in allergic children using epitope-specific IgE antibody profiling.

Autor: Suprun M; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Kearney P; AllerGenis LLC, Hatfield, Pennsylvania, USA., Hayward C; AllerGenis LLC, Hatfield, Pennsylvania, USA., Butler H; AllerGenis LLC, Hatfield, Pennsylvania, USA., Getts R; AllerGenis LLC, Hatfield, Pennsylvania, USA., Sicherer SH; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Turner PJ; National Heart & Lung Institute, Imperial College London, England, UK., Campbell DE; The University of Sydney, Sydney, New South Wales, Australia., Sampson HA; Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Publikováno v: Allergy [Allergy] 2022 Oct; Vol. 77 (10), pp. 3061-3069. Date of Electronic Publication: 2022 Aug 17.

Mapping Sequential IgE-Binding Epitopes on Major and Minor Egg Allergens.

Autor: Suprun M; Icahn School of Medicine at Mount Sinai, New York, New York, USA, suprun.maria@gmail.com., Sicherer SH; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Wood RA; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jones SM; University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA., Leung DYM; National Jewish Health, Denver, Colorado, USA., Burks AW; University of North Carolina, Chapel Hill, North Carolina, USA., Dunkin D; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Witmer M; AllerGenis LLC, Hatfield, Pennsylvania, USA., Grishina G; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Getts R; AllerGenis LLC, Hatfield, Pennsylvania, USA., Suárez-Fariñas M; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Sampson HA; Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Publikováno v: International archives of allergy and immunology [Int Arch Allergy Immunol] 2022; Vol. 183 (3), pp. 249-261. Date of Electronic Publication: 2021 Nov 24.