Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gessica, Marchini"'
Autor:
Elisabetta Armani, Andrea Rizzi, Nicolò Iotti, Francesca Saccani, Maria Rosaria Di Lascia, Laura Tigli, Alice Pappani, Gessica Marchini, Annalisa Murgo, Anna Maria Capelli, Maurizio Delcanale, Paola Puccini, Gino Villetti, Maurizio Civelli, Claudia Beato, Marta Giuliani, Claudia Mundi, Francesca Murarolli, Mafalda Pagano, Luca F. Raveglia, Rosaria Remelli, Gabriele Amari
Publikováno v:
Journal of Medicinal Chemistry. 66:5622-5656
Autor:
Maurizio Civelli, Anna Rita Pisano, Gino Villetti, Hervé Van de Poël, Francesco Amadei, Vanessa Pitozzi, Carmelida Capaldi, Gabriele Amari, Alice Pappani, Michela Salvadori, Fanti Renato De, Paola Puccini, Valentina Cenacchi, Wesley Blackaby, Maurizio Delcanale, Riccardo Patacchini, Kevin Nash, Andrea Rizzi, Gessica Marchini, Maria Pittelli, Marcello Trevisani, Elisabetta Armani, Charles Baker-Glenn
Publikováno v:
Journal of Medicinal Chemistry. 64:9100-9119
In this paper, we report the discovery of dual M3 antagonist-PDE4 inhibitor (MAPI) compounds for the inhaled treatment of pulmonary diseases. The identification of dual compounds was enabled by the intuition that the fusion of a PDE4 scaffold derived
Autor:
Elisabetta, Armani, Andrea, Rizzi, Carmelida, Capaldi, Renato, De Fanti, Maurizio, Delcanale, Gino, Villetti, Gessica, Marchini, Anna Rita, Pisano, Vanessa, Pitozzi, Maria Gloria, Pittelli, Marcello, Trevisani, Michela, Salvadori, Valentina, Cenacchi, Paola, Puccini, Francesco, Amadei, Alice, Pappani, Maurizio, Civelli, Riccardo, Patacchini, Charles A G, Baker-Glenn, Hervé, Van de Poël, Wesley P, Blackaby, Kevin, Nash, Gabriele, Amari
Publikováno v:
Journal of medicinal chemistry. 64(13)
In this paper, we report the discovery of dual M
Autor:
Maurizio Civelli, Alice Pappani, Paola Puccini, Elisabetta Armani, Laura Carzaniga, Silvia Catinella, Roberta Volta, Riccardo Patacchini, Gabriele Amari, Valentina Cenacchi, Maurizio Delcanale, Fabrizio Facchinetti, Chiara Carnini, Carmelida Capaldi, Silvia Capacchi, Andrea Rizzi, Gessica Marchini, Valentina Bagnacani, Gino Villetti, Nadia Moretto, Loredana Battipaglia, Paola Caruso, Francesco Amadei, Eleonora Ghidini, Fanti Renato De
Publikováno v:
Journal of Medicinal Chemistry. 60:10026-10046
Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary disease (COPD). Herein
Publikováno v:
European journal of pharmacology. 850
Cigarette smokers with asthma and chronic obstructive pulmonary disease (COPD) are less responsive to glucocorticoids (GCs). The anti-inflammatory action of GCs depends also on their ability to transactivate genes such as GC-induced leucine zipper (G
Autor:
Alessandro Fioni, Anna Maria Capelli, Chiara Carnini, Gessica Marchini, Fabio Rancati, Valentina Cenacchi, Eleonora Ghidini, Fabrizio Facchinetti
Publikováno v:
Journal of medicinal chemistry. 61(11)
Inhaled corticosteroids (ICSs) represent the first line therapy for the treatment of asthma and are also extensively utilized in chronic obstructive pulmonary disease. Our goal was to develop a new ICS with a basic group, which can allow solid state
Autor:
Fabrizio Facchinetti, Eleonora Ghidini, Valentina Cenacchi, Anna Maria Capelli, A. Virdis, A. Italia, Chiara Carnini, Gessica Marchini
Publikováno v:
Steroids. 95:88-95
A novel glucocorticoids series of (GCs), 6α,9α-di-Fluoro 3-substituted C-16,17-isoxazolines was designed, synthesised and their structure–activity relationship was evaluated with glucocorticoid receptor (GR) binding studies together with GR nucle
Autor:
Maurizio Civelli, Carola Buccellati, Angelo Sala, Fabrizio Facchinetti, Laura Carzaniga, Eleonora Ghidini, Gabriele Amari, Fanti Renato De, Fiorella Pastore, Chiara Carnini, Paola Caruso, Maurizio Delcanale, Elisabetta Armani, Gino Villetti, Carmelida Capaldi, Riccardo Patacchini, Gessica Marchini, Andrea Rizzi, Emilio Hirsch, Raffaella Bosco, Nadia Moretto
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 352:559-567
This study examined the pharmacologic characterization of CHF6001 [(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide], a novel phosphodiesterase (
Autor:
Stefano Cavalli, Fabrizio Facchinetti, Alessandro Accetta, Silvia Cantoni, Gino Villetti, Fiorella Pastore, Gessica Marchini, Serena Bertolini
Publikováno v:
Pulmonary Circulation and Pulmonary Vascular Disease.
Studies aiming at elucidating the pathophysiological roles of Rho kinase (ROCK) in experimental pulmonary artery hypertension (PAH) mainly relies on a limited number of not very selective pharmacological inhibitors. From a patent we have identified t
Autor:
Fabrizio Facchinetti, Silvia Cantoni, Alessandro Accetta, Gessica Marchini, Stefano Cavalli, Gino Villetti, Maurizio Civelli, Fiorella Pastore, Serena Bertolini
Publikováno v:
European Heart Journal. 38