Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Autor: Qi Hao, Manoj K. Rathinaswamy, Kelly L. Klinge, Matthew Bratkowski, Amirhossein Mafi, Christina K. Baumgartner, Keith M. Hamel, Gesine K. Veits, Rinku Jain, Claudio Catalano, Mark Fitzgerald, Alexander W. Hird, Eunice Park, Harit U. Vora, James A. Henderson, Kenton Longenecker, Charles W. Hutchins, Wei Qiu, Giovanna Scapin, Qi Sun, Vincent S. Stoll, Chaohong Sun, Ping Li, Dan Eaton, David Stokoe, Stewart L. Fisher, Christopher G. Nasveschuk, Marcia Paddock, Michael E. Kort

Publikováno v: Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)

Abstract PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models. Targeted protein degradation ha

Externí odkaz: https://doaj.org/article/1f2680b79836478cba894b08e1a585a6

Abstract ND09: The discovery and characterization of CFT8634: A potent and selective degrader of BRD9 for the treatment of SMARCB1-perturbed cancers

Autor: Katrina L. Jackson, Roman V. Agafonov, Mark W. Carlson, Prasoon Chaturvedi, David Cocozziello, Kyle Cole, Richard Deibler, Scott J. Eron, Andrew Good, Ashley A. Hart, Minsheng He, Christina S. Henderson, Hongwei Huang, Marta Isasa, R. Jason Kirby, Linda Lee, Michelle Mahler, Moses Moustakim, Christopher G. Nasveschuk, Michael Palmer, Laura L. Poling, Roy M. Pollock, Matthew Schnaderbeck, Stan Spence, Gesine K. Veits, Jeremy L. Yap, Ning Yin, Rhamy Zeid, Adam S. Crystal, Andrew J. Phillips, Stewart L. Fisher

Publikováno v: Cancer Research. 82:ND09-ND09

Introduction: The chromatin factor BRD9 is a genetic dependency in some cancers, often referred to as SMARCB1-perturbed cancers. Two types of genetic alterations result in SMARCB1 perturbation: SS18-SSX gene fusion and SMARCB1 loss-of-function mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96b44ef5d9fa5dc56a4a294008bf6985
https://doi.org/10.1158/1538-7445.am2022-nd09

Tandem Reaction Progress Analysis as a Means for Dissecting Catalytic Reactions: Application to the Aza-Piancatelli Rearrangement

Autor: Javier Read de Alaniz, Diana Yu, Ryan Chung, Jason E. Hein, Alyssa F. Jones, Van T. Thai, Gesine K. Veits

Publikováno v: ACS Catalysis, vol 5, iss 8
Chung, R; Yu, D; Thai, VT; Jones, AF; Veits, GK; Read De Alaniz, J; et al.(2015). Tandem Reaction Progress Analysis as a Means for Dissecting Catalytic Reactions: Application to the Aza-Piancatelli Rearrangement. ACS Catalysis, 5(8), 4579-4585. doi: 10.1021/acscatal.5b01087. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/892067f4

© 2015 American Chemical Society. Continuing developments in the elucidation techniques of complex catalytic processes is of foremost importance to modern synthetic chemistry, and the identification of efficient synthetic techniques relies on precis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd559f170bfd48c4e1df33e32b4eeb60
https://doi.org/10.1021/acscatal.5b01087

Rapid Synthesis of Fused Oxabicycles through the Molecular Rearrangement of Spirocyclic Ethers

Autor: Javier Read de Alaniz, Gesine K. Veits, Leoni I. Palmer

Publikováno v: European Journal of Organic Chemistry. 2013:6237-6240

A molecular rearrangement of 5,5-spirocyclic cyclopentenones to 5,6-fused cyclopentenones catalyzed by Amberlyst®15 is described. This work emphasizes the utility of renewable resources, such as furfural, that can be transformed into a variety of va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68785b810706a52d96c791ccde7419f9
https://doi.org/10.1002/ejoc.201300832

Dysprosium(III) catalysis in organic synthesis

Autor: Gesine K. Veits, Javier Read de Alaniz

Publikováno v: Tetrahedron. 68:2015-2026

Review: dysprosium(III) salts as extremely mild and efficient Lewis acid catalysts for numerous types of carbon—carbon bond forming reactions; 56 refs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1344623774df0497753b6726db30b5f6
https://doi.org/10.1016/j.tet.2011.11.042