Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

Autor: Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher, Vigo Heissmeyer

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

An extensive RNA binding protein atlas (RBPome) for primary T cells would be a useful resource. Here the authors use two different methods to characterise the mouse and human T cell RBPome and show regulation of Roquin-1/2 dependent and independent p

Externí odkaz: https://doaj.org/article/79f61fbb2db9463391f56fc5ab732e2e

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Autor: Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan, Vigo Heissmeyer

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and s

Externí odkaz: https://doaj.org/article/314fcd580797451983c726cd599eaae1

Cooperation of RNA-Binding Proteins - a Focus on Roquin Function in T Cells

Autor: Gesine Behrens, Vigo Heissmeyer

Publikováno v: Front. Immunol. 13:839762 (2022)
Frontiers in Immunology, Vol 13 (2022)

Post-transcriptional gene regulation by RNA-binding proteins (RBPs) is important in the prevention of inflammatory and autoimmune diseases. With respect to T cell activation and differentiation, the RBPs Roquin-1/2 and Regnase-1 play pivotal roles by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68133c4dc2f8ff589e9a4fd661c2cc07
https://pubmed.ncbi.nlm.nih.gov/35251035

Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3

Autor: Benjamin Busch, Veit Hornung, Gesine Behrens, Matthias von Gamm, Wolfgang Wurst, Arie Geerlof, Johannes Lichti, Regina Feederle, Annalisa Schaub, Dhruv Chauhan, Elke Glasmacher, Katharina Essig, Annette Feuchtinger, Alisha N Jones, Christine Wolf, Andreas Ehrlich, Caroline C. Friedel, Kathrin Davari, Vigo Heissmeyer, Michael Sattler, Matthias H. Tschöp, Mathias Heikenwalder, Joachim Pircher, Anna Macht, Christian Schulz, Stefanie M. Hauck

Publikováno v: J. Exp. Med. 216, 1700-1723 (2019)
The Journal of Experimental Medicine
Journal of experimental medicine 216(7), 1700-1723 (2019). doi:10.1084/jem.20181762

von Gamm et al. demonstrate that mice deficient for the RNase Regnase-3 (Zc3h12c) develop hypertrophic lymph nodes and a systemic interferon response. Regnase-3 is a functional RNase that acts in myeloid cells upon IRF signaling, suggesting it to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6ae2c005f84820cba549cbfe6e849d
https://doi.org/10.1084/jem.20181762

A translational silencing function of MCPIP1/Regnase-1 specified by the target site context

Autor: Nina Rehage, Gesine Behrens, Christopher Tiedje, Vigo Heissmeyer, Anne Hoffmann, Reinhard Winzen, Anneke Dörrie, Helmut Holtmann, Monika Barsch, Jörg Hackermüller

Publikováno v: Nucleic Acids Research
Nucleic Acids Res. 46, 4256-4270 (2018)

Aromatic hydrocarbons belong to the most abundant contaminants in groundwater systems. They can serve as carbon and energy source for a multitude of indigenous microorganisms. Predictions of contaminant biodegradation and microbial growth in contamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cefc02c179427c9e1fd6139c8cde78
http://europepmc.org/articles/PMC5934641