Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson’s Disease and Multiple System Atrophy

Autor: Berkiye Sonustun, Melek Firat Altay, Catherine Strand, Kirsten Ebanks, Geshanthi Hondhamuni, Thomas T. Warner, Hilal A. Lashuel, Rina Bandopadhyay

Publikováno v: Cells, Vol 11, Iss 5, p 906 (2022)

Aggregated alpha-synuclein (α-synuclein) is the main component of Lewy bodies (LBs), Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological hallmarks of idiopathic Parkinson’s disease (IPD) and multiple system atrophy

Externí odkaz: https://doaj.org/article/c09f6ecd7aea4af1a725ba337ebb3db0

High expression of nicotinamide N-methyltransferase in patients with sporadic Alzheimer’s disease

Autor: Linda Parsons, Altin Kocinaj, Rashad R. Junaid, David B. Ramsden, Tabassum Chaudhury, Richard B. Parsons, Geshanthi Hondhamuni, Fábio Klamt, Mohammed S. Uddin

Publikováno v: Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Molecular Neurobiology

We have previously shown that the expression of nicotinamide N-methyltransferase (NNMT) is significantly increased in the brains of patients who have died of Parkinson’s disease (PD). In this study, we have compared the expression of NNMT in post-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02041bb57be5ee221951ddcb5146dbe7

Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies

Autor: Kaj Blennow, David R. Williams, Ana Cámara, Yolande A.L. Pijnenburg, Radu Constantinescu, Perdita Anne Cheshire, Claudia Trenkwalder, Rohan de Silva, Barbara Borroni, Brit Mollenhauer, Yaroslau Compta, John C. van Swieten, Connie Luk, Henrik Zetterberg, Wan Zheng Chiu, Nadia K. Magdalinou, Andrew J. Lees, María José Martí, Geshanthi Hondhamuni

Publikováno v: Luk, C, Compta, Y, Magdalinou, N, Marti, M J, Hondhamuni, G, Zetterberg, H, Blennow, K, Constantinescu, R, Pijnenburg, Y A L, Mollenhauer, B, Trenkwalder, C, van Swieten, J C, Chiu, W Z, Borroni, B, Camara, A, Cheshire, P, Williams, D R, Lees, A J & de Silva, R 2012, ' Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three-and four-repeat tau isoforms in tauopathies ', Journal of Neurochemistry, vol. 123, no. 3, pp. 396-405 . https://doi.org/10.1111/j.1471-4159.2012.07911.x
Journal of Neurochemistry, 123(3), 396-405. Wiley-Blackwell Publishing Ltd
Journal of Neurochemistry, 123(3), 396-405. Wiley-Blackwell

Characteristic tau isoform composition of the insoluble fibrillar tau inclusions define tauopathies, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and frontotemporal dementia with parkinsonism linked to chromosome 17/fronto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6041045a1ff3d9b3efde0f48c7f56a8b
http://hdl.handle.net/11379/164877

P3‐119: Investigation of the role of tau gene transcriptional regulation in neurodegeneration

Autor: Roberto Simone, Geshanthi Hondhamuni, Rohan de Silva, Juan Anaya, Andrew J. Lees, Victoria Kay

Publikováno v: Alzheimer's & Dementia. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7114c2fc4e09aa8603e04afdf1210d53
https://doi.org/10.1016/j.jalz.2011.05.1559

Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies

Autor: Zeshan Ahmed, Janice L. Holton, Rohan de Silva, Laura Silveira-Moriyama, Stephen Wroe, Andrew J. Lees, Geshanthi Hondhamuni, Selina Wray, Tammaryn Lashley, Sean S. O'Sullivan, Adamantios Mamais, Jia Newcombe, Tamas Revesz, Karen M. Doherty, Rina Bandopadhyay

Publikováno v: Acta neuropathologica. 122(4)

A number of recent studies have described cases with tau-positive globular oligodendroglial inclusions (GOIs) and such cases have overlapping pathological features with progressive supranuclear palsy (PSP), but present with clinical features of motor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dba00040b5c0dd7a84a44fe78226268
https://pubmed.ncbi.nlm.nih.gov/23700215