Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gesa König"'
Autor:
Joel Fauser, Burak Gulen, Vivian Pogenberg, Christian Pett, Danial Pourjafar-Dehkordi, Christoph Krisp, Dorothea Höpfner, Gesa König, Hartmut Schlüter, Matthias J. Feige, Martin Zacharias, Christian Hedberg, Aymelt Itzen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The ER chaperone BiP is critical for the unfolded protein response and tightly regulated through reversible AMPylation by FICD, but the structural basis is unknown. Here the authors use thiol-reactive nucleotide derivatives to stabilize the transient
Externí odkaz:
https://doaj.org/article/5b881075f8d343709870eb7b338a3da3
Autor:
Anton Letzer, Katja Lehmann, Christian Mess, Gesa König, Tobias Obser, Sven Peine, Sonja Schneppenheim, Ulrich Budde, Stefan W Schneider, Reinhard Schneppenheim, Maria A Brehm
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232637 (2020)
ADAMTS13 regulates the hemostatic activity of von Willebrand factor (VWF). Determined by static assays, proteolytic activity
Externí odkaz:
https://doaj.org/article/53fef788d1eb457e873b2fe593502998
Autor:
Hilger Jagau, Ina-Kristin Behrens, Karen Lahme, Georgina Lorz, Reinhard W. Köster, Reinhard Schneppenheim, Tobias Obser, Maria A. Brehm, Gesa König, Thomas P. Kohler, Manfred Rohde, Ronald Frank, Werner Tegge, Marcus Fulde, Sven Hammerschmidt, Michael Steinert, Simone Bergmann
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Streptococcus pneumoniae is a major cause of community acquired pneumonia and septicaemia in humans. These diseases are frequently associated with thromboembolic cardiovascular complications. Pneumococci induce the exocytosis of endothelial Weibel-Pa
Externí odkaz:
https://doaj.org/article/2f4315b814da42b68805ff930cfd2697
Autor:
Achim Löf, Gesa König, Sonja Schneppenheim, Reinhard Schneppenheim, Martin Benoit, Ulrich Budde, Jochen P Müller, Maria A Brehm
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210963 (2019)
The formation of hemostatic plugs at sites of vascular injury crucially involves the multimeric glycoprotein von Willebrand factor (VWF). VWF multimers are linear chains of N-terminally linked dimers. The latter are formed from monomers via formation
Externí odkaz:
https://doaj.org/article/3b653d22bd2943ca992fde80155b81f8
Autor:
Sandra Posch, Camilo Aponte-Santamaría, Richard Schwarzl, Andreas Karner, Matthias Radtke, Frauke Gräter, Tobias Obser, Gesa König, Maria A. Brehm, Hermann J. Gruber, Roland R. Netz, Carsten Baldauf, Reinhard Schneppenheim, Robert Tampé, Peter Hinterdorfer
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 1080-1087 (2016)
We here give information for a deeper understanding of single molecule force spectroscopy (SMFS) data through the example of the blood protein von Willebrand factor (VWF). It is also shown, how fitting of rupture forces versus loading rate profiles i
Externí odkaz:
https://doaj.org/article/a6af907a1b04473db79970e4cbf3d20c
Autor:
Sophia Gruber, Achim Löf, Adina Hausch, Fabian Kutzki, Res Jöhr, Tobias Obser, Gesa König, Reinhard Schneppenheim, Camilo Aponte-Santamaría, Frauke Gräter, Maria A. Brehm, Martin Benoit, Jan Lipfert
Publikováno v:
Blood Advances. 6:5198-5209
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the trans-Golgi is still not fully understood. We use the single-molecule
Autor:
Martin Zacharias, Christian Hedberg, Christoph Krisp, Joel Fauser, Matthias J. Feige, Christian Pett, Aymelt Itzen, Dorothea Höpfner, Danial Pourjafar-Dehkordi, Burak Gulen, Gesa König, Hartmut Schlüter, Vivian Pogenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications 12(1), 2426 (2021). doi:10.1038/s41467-021-22596-0
Nature Communications
Nature Communications 12(1), 2426 (2021). doi:10.1038/s41467-021-22596-0
Nature Communications
Nature Communications 12(1), 2426 (2021). doi:10.1038/s41467-021-22596-0
To adapt to fluctuating protein folding loads in the endoplasmic reticulum (ER), the Hsp70 chaperone BiP is reversibly modified with adenosine monophosphate (AMP) by the ER
To adapt to fluctuating protein folding loads in the endoplasmic reticulum (ER), the Hsp70 chaperone BiP is reversibly modified with adenosine monophosphate (AMP) by the ER
Autor:
Adiran Garaizar, Volker Huck, Joachim O. Rädler, Stefan W. Schneider, Maria A. Brehm, Angelica Sandoval-Perez, Gesa König, Stephen E. Farr, Ricarda M L Berger, Rosana Collepardo-Guevara, Camilo Aponte-Santamaría
Publikováno v:
Nucleic Acids Research
Neutrophils release their intracellular content, DNA included, into the bloodstream to form neutrophil extracellular traps (NETs) that confine and kill circulating pathogens. The mechanosensitive adhesive blood protein, von Willebrand Factor (vWF), i
Autor:
Matthias Wilmanns, Stefan W. Schneider, Maria A. Brehm, Volker Huck, Cécile V. Denis, Po-chia Chen, Gesa König, Frauke Gräter, Emma Ruoqi Xu, Christian Mess, Reinhard Schneppenheim, Fabian Kutzki, Tobias Obser, Ulrike Klemm, Matthew Auton, Alexander Tischer, Janosch Hennig, Camilo Aponte-Santamaría
Publikováno v:
Thrombosis and Haemostasis, 5
Thrombosis and haemostasis 122(02), 226-239 (2022). doi:10.1055/a-1344-4405
Thrombosis and haemostasis 122(02), 226-239 (2022). doi:10.1055/a-1344-4405
Thrombosis and haemostasis 122(02), 226 - 239 (2022). doi:10.1055/a-1344-4405
The multimeric plasma glycoprotein (GP) von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mut
The multimeric plasma glycoprotein (GP) von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mut
Autor:
Reinhard Schneppenheim, Gesa König, Tobias Obser, Stefan W. Schneider, Volker Huck, Maria A. Brehm
Publikováno v:
Hamburger Hämophilie Symposion Hamburg, Germany.