Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Gerwin, Heller"'
Autor:
Jana Trifinopoulos, Julia List, Thorsten Klampfl, Klara Klein, Michaela Prchal-Murphy, Agnieszka Witalisz-Siepracka, Florian Bellutti, Luca L. Fava, Gerwin Heller, Sarah Stummer, Patricia Testori, Monique L. den Boer, Judith M. Boer, Sonja Marinovic, Gregor Hoermann, Wencke Walter, Andreas Villunger, Piotr Sicinski, Veronika Sexl, Dagmar Gotthardt
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of cancer research
Externí odkaz:
https://doaj.org/article/8800b97f24a34ac584683af5d6db62a8
Autor:
Vanessa Maria Knab, Dagmar Gotthardt, Klara Klein, Reinhard Grausenburger, Gerwin Heller, Ingeborg Menzl, Daniela Prinz, Jana Trifinopoulos, Julia List, Daniela Fux, Agnieszka Witalisz-Siepracka, Veronika Sexl
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Abstract Triple-negative breast cancer (TNBC) is an aggressive malignant disease that is responsible for approximately 15% of breast cancers. The standard of care relies on surgery and chemotherapy but the prognosis is poor and there is an urgent nee
Externí odkaz:
https://doaj.org/article/7325c12c85af4d8aae4f8418324ba67e
Autor:
Ulrike Schmidt, Gerwin Heller, Gerald Timelthaler, Petra Heffeter, Zsolt Somodi, Norbert Schweifer, Maria Sibilia, Walter Berger, Agnes Csiszar
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-21 (2021)
Abstract Background Gene amplification of MET, which encodes for the receptor tyrosine kinase c-MET, occurs in a variety of human cancers. High c-MET levels often correlate with poor cancer prognosis. Interleukin-like EMT inducer (ILEI) is also overe
Externí odkaz:
https://doaj.org/article/3fb71a0b63bd4e22a31d76f2d1a78286
Autor:
Matthias Preusser, Anna Sophie Berghoff, Thorsten Fuereder, Leonhard Müllauer, Gerwin Heller, Angelika Martina Starzer, Katharina Feldmann, Erwin Tomasich, Teresa Hatziioannou, Stefan Traint, Thomas Melchardt, Christoph Minichsdorfer, Ursula Schwarz-Nemec, Maja Nackenhorst
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Biomarkers for response prediction to anti-programmed cell death 1 (PD-1) immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC) are urgently needed for a personalized therapy approach. We investi
Externí odkaz:
https://doaj.org/article/e6550fd49f974f6795b61c4497460f1c
Autor:
Matthias Millesi, Alice Senta Ryba, Johannes A. Hainfellner, Thomas Roetzer, Anna Sophie Berghoff, Matthias Preusser, Gerwin Heller, Erwin Tomasich, Felix Sahm, Karl Roessler, Stefan Wolfsberger
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundAccounting for 15–20% of all meningiomas, WHO grade II meningiomas represent an intermediate group regarding risk of tumor recurrence. However, even within this subgroup varying clinical courses are observed with potential occurrence of m
Externí odkaz:
https://doaj.org/article/d19636c3afd048e88057279c3151a4dd
Autor:
Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M. Knab, Iris Z. Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M. Hatcher, Yanke Liang, Nicholas P. Kwiatkowski, Daniela Fux, Andrea Hoelbl-Kovacic, Stefan Kubicek, Junia V. Melo, Peter Valent, Thomas Weichhart, Florian Grebien, Johannes Zuber, Nathanael S. Gray, Veronika Sexl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signal
Externí odkaz:
https://doaj.org/article/90ab601100a74a6da15edcbbea0a9c4e
Autor:
Nicole Amberg, Panagiota A. Sotiropoulou, Gerwin Heller, Beate M. Lichtenberger, Martin Holcmann, Bahar Camurdanoglu, Temenuschka Baykuscheva-Gentscheva, Cedric Blanpain, Maria Sibilia
Publikováno v:
iScience, Vol 15, Iss , Pp 243-256 (2019)
Summary: Epidermal growth factor receptor (EGFR) signaling controls skin development and homeostasis in mice and humans, and its deficiency causes severe skin inflammation, which might affect epidermal stem cell behavior. Here, we describe the inflam
Externí odkaz:
https://doaj.org/article/fec4df02adcd448198444c8a11fb38f7
Autor:
Elisabeth Sophie Bergen, Amelie Binter, Angelika Martina Starzer, Gerwin Heller, Barbara Kiesel, Kristina Tendl-Schulz, Zsuzsanna Bago-Horvath, Julia Furtner, Johannes Leitner, Ruth Exner, Florian Fitzal, Karin Dieckmann, Georg Widhalm, Matthias Preusser, Anna Sophie Berghoff, Rupert Bartsch
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: Dual human epidermal growth factor receptor 2 (HER2) blockade with trastuzumab and pertuzumab (TP) is a standard therapy of metastatic and localized HER2-positive breast cancer (BC), but its activity in breast cancer brain metastases (BCB
Externí odkaz:
https://doaj.org/article/4eb2fe5fd3694a6a890ef4fe3c3a3a7b
Autor:
Matthias Preusser, Leonhard Müllauer, Anna S Berghoff, Sebastian Bauer, Gerwin Heller, Thomas Brodowicz, Wolfgang Lamm, Katharina Feldmann, Angelika M Starzer, Rainer Hamacher, Erwin Tomasich, Teresa Hatziioannou, Stefan Traint, Iris M Noebauer-Huhmann, Julia Furtner, Gabriele Amann, Hans-Ulrich Schildhaus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Some sarcomas respond to immune checkpoint inhibition, but predictive biomarkers are unknown. We analyzed tumor DNA methylation profiles in relation to immunological parameters and response to anti-programmed cell death 1 (anti-PD-1) immun
Externí odkaz:
https://doaj.org/article/a79916ad1b1542e9b504874a3913dd32
Autor:
Erwin Tomasich, Ariane Steindl, Christina Paiato, Teresa Hatziioannou, Markus Kleinberger, Luzia Berchtold, Rainer Puhr, Johannes A. Hainfellner, Leonhard Müllauer, Georg Widhalm, Franziska Eckert, Rupert Bartsch, Gerwin Heller, Matthias Preusser, Anna Sophie Berghoff
Publikováno v:
Clinical Cancer Research. :OF1-OF12
Purpose: HER3 belongs to a family of receptor tyrosine kinases with oncogenic properties and is targeted by a variety of novel anticancer agents. There is a huge unmet medical need for systemic treatment options in patients with brain metastases (BM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::041fbda11e13ad493cbe7ffb8f8ba787
https://doi.org/10.1158/1078-0432.ccr-23-0020
https://doi.org/10.1158/1078-0432.ccr-23-0020