Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Gerwald Jogl"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The long interspersed nuclear element-1 (LINE-1 or L1) retrotransposon is the only active autonomously replicating retrotransposon in the human genome. L1 harms the cell by inserting new copies, generating DNA damage, and triggering inflamma
Externí odkaz:
https://doaj.org/article/5e4909ae224c43a3913f3fc5d61b1e24
Publikováno v:
Antibiotics, Vol 10, Iss 11, p 1384 (2021)
Rhodothermus marinus is a halophilic extreme thermophile, with potential as a model organism for studies of the structural basis of antibiotic resistance. In order to facilitate genetic studies of this organism, we have surveyed the antibiotic sensit
Externí odkaz:
https://doaj.org/article/1a18f87c42764ee38afae6120ef9ca77
Publikováno v:
Antibiotics, Vol 9, Iss 6, p 313 (2020)
Tiamulin is a semisynthetic pleuromutilin antibiotic that binds to the 50S ribosomal subunit A site and whose (((2-diethylamino)ethyl)thio)-acetic acid tail extends into the P site to interfere with peptide bond formation. We have isolated spontaneou
Externí odkaz:
https://doaj.org/article/fab74adf45164b9fbcbbfbcda470ac9a
Autor:
Guray Kuzu, Emily G Kaye, Jessica Chery, Trevor Siggers, Lin Yang, Jason R Dobson, Sonia Boor, Jacob Bliss, Wei Liu, Gerwald Jogl, Remo Rohs, Nadia D Singh, Martha L Bulyk, Michael Y Tolstorukov, Erica Larschan
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006120 (2016)
Dosage compensation is an essential process that equalizes transcript levels of X-linked genes between sexes by forming a domain of coordinated gene expression. Throughout the evolution of Diptera, many different X-chromosomes acquired the ability to
Externí odkaz:
https://doaj.org/article/059126ee109c4fffbd67b17d9cc244b2
The long interspersed nuclear element-1 (LINE-1 or L1) retrotransposon is the only active autonomously replicating retrotransposon in the human genome. While most of the approximately 500,000 L1 copies are no longer able to propagate, those that reta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d227429b87e33b9f88a5cc229061b7
https://doi.org/10.1101/2022.12.29.522256
https://doi.org/10.1101/2022.12.29.522256
Autor:
Jocelyn C. Newton, Nicolas L. Fawzi, John M. Sedivy, Mandar T. Naik, Grace Y. Li, Gerwald Jogl, Eileen L. Murphy
Publikováno v:
Biophys J
Long interspersed nuclear element-1 (L1) is a retrotransposable element that autonomously replicates in the human genome, resulting in DNA damage and genomic instability. Activation of L1 in senescent cells triggers a type I interferon response and a
Autor:
Chinmai Pindi, Souvik Sinha, Helen Belato, Carmelissa Norbrun, Jinping Luo, Alexandra M. D'Ordine, Gerwald Jogl, George Lisi, Giulia Palermo
Publikováno v:
Biophysical Journal. 122:138a
Autor:
Helen B. Belato, Carmelissa Norbrun, Jinping Luo, Chinmai Pindi, Souvik Sinha, Alexandra M. D’Ordine, Gerwald Jogl, Giulia Palermo, George P. Lisi
Publikováno v:
The Journal of Chemical Physics. 157:225103
Allosteric signaling within multidomain proteins is a driver of communication between spatially distant functional sites. Understanding the mechanism of allosteric coupling in large multidomain proteins is the most promising route to achieving spatia
Autor:
Reza Khayat, Bryant Avila, Barbara E. Murray, Eileen L Murphy, Gerwald Jogl, Kurt L. Krause, Steven T. Gregory, Torsten Kleffmann, Kavindra V. Singh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Enterococcus faecalis is a gram-positive organism responsible for serious infections in humans, but as with many bacterial pathogens, resistance has rendered a number of commonly used antibiotics ineffective. Here, we report the cryo-EM structure of