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Akademický článek

Leveraging gene correlations in single cell transcriptomic data

Autor: Kai Silkwood, Emmanuel Dollinger, Joshua Gervin, Scott Atwood, Qing Nie, Arthur D. Lander

Publikováno v: BMC Bioinformatics, Vol 25, Iss 1, Pp 1-43 (2024)

Abstract Background Many approaches have been developed to overcome technical noise in single cell RNA-sequencing (scRNAseq). As researchers dig deeper into data—looking for rare cell types, subtleties of cell states, and details of gene regulatory

Externí odkaz: https://doaj.org/article/1c805c6f0a6e47c8a01756342320121c

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Akademický článek

Citalopram exposure of hESCs during neuronal differentiation identifies dysregulated genes involved in neurodevelopment and depression

Autor: Mari Spildrejorde, Magnus Leithaug, Athina Samara, Hans Christian D. Aass, Ankush Sharma, Ganesh Acharya, Hedvig Nordeng, Kristina Gervin, Robert Lyle

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Selective serotonin reuptake inhibitors (SSRIs), including citalopram, are widely used antidepressants during pregnancy. However, the effects of prenatal exposure to citalopram on neurodevelopment remain poorly understood. We aimed to investigate the

Externí odkaz: https://doaj.org/article/2b228cf75b92424588deea0c5511a3cd

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Akademický článek

Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet

Autor: Sigrid Pedersen, Magnhild Kverneland, Knut Rudi, Kristina Gervin, Cecilie Johannessen Landmark, Per Ole Iversen, Kaja Kristine Selmer

Publikováno v: Epilepsia Open, Vol 8, Iss 3, Pp 858-866 (2023)

Abstract Objective To examine the potential influence of a ketogenic diet on serum concentrations of antiseizure medications (ASMs) in children with drug resistant epilepsy. Methods We investigated the serum concentrations of ASMs in 25 children with

Externí odkaz: https://doaj.org/article/13ef7f1ede34443ebe667428f9534f95

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Akademický článek

The joint effect of female sex and food insecurity on self-reported mood disorder among Canadian adults: the Canadian community health survey

Autor: James Kotuah Sakeah, Gervin Ane Apatinga, Edgar Balinia Adda, Paschal Awingura Apanga, Carol Vlassoff, Yue Chen

Publikováno v: BMC Nutrition, Vol 9, Iss 1, Pp 1-8 (2023)

Abstract Background Food insecurity is prevalent in Canada and may influence mental health, particularly among females. The present study examined the joint effect of female sex and food insecurity on mood disorders. Methods The study used data from

Externí odkaz: https://doaj.org/article/8f0c98807647400f809daa786158ddd7

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Akademický článek

Cytokine Patterns as Predictors of Antibiotic Treatment Effect in Chronic Low Back Pain with Modic Changes: Subgroup Analyses of a Randomized Trial (AIM Study)

Autor: Bråten LCH, Gjefsen E, Gervin K, Pripp AH, Skouen JS, Schistad E, Pedersen LM, Wigemyr M, Selmer KK, Aass HCD, Goll G, Brox JI, Espeland A, Grøvle L, Zwart JA, Storheim K

Publikováno v: Journal of Pain Research, Vol Volume 16, Pp 1713-1724 (2023)

Lars Christian Haugli Bråten,1 Elisabeth Gjefsen,1,2 Kristina Gervin,1 Are Hugo Pripp,3 Jan Sture Skouen,4 Elina Schistad,5 Linda Margareth Pedersen,1 Monica Wigemyr,1 Kaja Kristine Selmer,1 Hans Christian Dalsbotten Aass,6 Guro Goll,7 Jens Ivar Bro

Externí odkaz: https://doaj.org/article/4351788809c349d6ae26c461967a67af

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Akademický článek

Effects of prenatal exposure to (es)citalopram and maternal depression during pregnancy on DNA methylation and child neurodevelopment

Autor: Emilie Willoch Olstad, Hedvig Marie Egeland Nordeng, Geir Kjetil Sandve, Robert Lyle, Kristina Gervin

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Studies assessing associations between prenatal exposure to antidepressants, maternal depression, and offspring DNA methylation (DNAm) have been inconsistent. Here, we investigated whether prenatal exposure to citalopram or escitalopram ((es

Externí odkaz: https://doaj.org/article/1829ff5da09f4742956c92e5b9567707

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