Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Gertrude B. Elion"'
Autor:
Gertrude B. Elion, George H. Hitchings
Publikováno v:
Annals of the New York Academy of Sciences. 129:799-803
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9dfc04d0855724a7ce4eeca5aa410f7
https://doi.org/10.1111/j.1749-6632.1966.tb12897.x
https://doi.org/10.1111/j.1749-6632.1966.tb12897.x
Autor:
Varsha Gandhi, Beverly S. Mitchell, C. Stephens, Joanne J. Lager, M.J. Keating, J.P. Hodge, T. Krenitsky, Joanne Kurtzberg, T.J. Ernst, Gertrude B. Elion, J. Levin, David F. Kisor
Publikováno v:
Journal of Clinical Oncology. 23:3396-3403
Purpose A phase I study was conducted to determine the maximum-tolerated dose (MTD), toxicity profile, and pharmacokinetics of a novel purine nucleoside, nelarabine, a soluble prodrug of 9-beta-D-arabinosylguanine (araG; Nelarabine), in pediatric and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b4460682cdc66461a26fa41ddd4b16
https://doi.org/10.1200/jco.2005.03.199
https://doi.org/10.1200/jco.2005.03.199
Autor:
Stewart P. Johnson, Stephen T. Keir, Peter J. Houghton, Darell D. Bigner, Gertrude B. Elion, Henry S. Friedman, Robert C. Castellino
Publikováno v:
Cancer Chemotherapy and Pharmacology. 45:345-349
Purpose: To further evaluate the activity of irinotecan (CPT-11) plus 1,3-bis-(chloroethyl)-1-nitrosourea (BCNU) in the treatment of central nervous system tumor-derived xenografts in athymic nude mice. Methods: We report studies evaluating the sched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bc570c51613023cf20d74f442b402f
https://doi.org/10.1007/s002800050050
https://doi.org/10.1007/s002800050050
Autor:
Lilia M. Beauchamp, Howard J. Schaeffer, Gertrude B. Elion, Paulo de Miranda, James A. Fyfe, Phillip A. Furman
Publikováno v:
Reviews in Medical Virology. 9:147-153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7921e4095107c207351bb24d4702065b
https://doi.org/10.1002/(sici)1099-1654(199907/09)9:3<147::aid-rmv255>3.0.co
https://doi.org/10.1002/(sici)1099-1654(199907/09)9:3<147::aid-rmv255>3.0.co
Autor:
Darell D. Bigner, Henry S. Friedman, Peter J. Houghton, Colvin Om, C B Hare, Stephen T. Keir, Gertrude B. Elion, C A Coggins
Publikováno v:
Cancer Chemotherapy and Pharmacology. 41:485-490
Two major obstacles in the treatment of patients with central nervous system malignancies are drug resistance and host toxicity. The goal of combination chemotherapy is to achieve therapeutic effects that are more favorable than using a single drug a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d9fd7fa80af2e11441314ef9867f8d
https://doi.org/10.1007/s002800050771
https://doi.org/10.1007/s002800050771
Autor:
Henry S. Friedman, Owen W. Griffith, S. L. Marcelli, William P. Petros, Colvin Om, Darell D. Bigner, Stephen T. Keir, C B Hare, Francis Ali-Osman, Gertrude B. Elion
Publikováno v:
Cancer Chemotherapy and Pharmacology. 40:409-414
Busulfan is an alkylating agent commonly used in the treatment of chronic myelogenous leukemia and in combination with cyclophosphamide in preparation for allogeneic bone marrow transplantation. Serial treatment of a childhood high-grade glioma xenog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3315a8a701b26d42d48fd016430833
https://doi.org/10.1007/s002800050678
https://doi.org/10.1007/s002800050678
Publikováno v:
Trends in Pharmacological Sciences. 18:3-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7eeed37e91a802fdddd9a002fa2fac9
https://doi.org/10.1016/s0165-6147(96)01007-3
https://doi.org/10.1016/s0165-6147(96)01007-3
Autor:
Charles N. Pegram, Darell D. Bigner, Daniel Wellner, Henry S. Friedman, Gertrude B. Elion, Kate Moynihan, Owen W. Griffith, Craig J. Reist
Publikováno v:
Cancer Chemotherapy and Pharmacology. 39:179-186
These studies evaluated the efficacy of sequential pretreatment with L-amino acid oxidase (LOX) and LOX antiserum in the modulation of melphalan activity against intracranial glioma in athymic nude mice. LOX produced statistically significant (P0.01)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c2b937da5040af9e3f3163e9d42ea3
https://doi.org/10.1007/s002800050557
https://doi.org/10.1007/s002800050557
Autor:
Mark W. Dewhirst, Gertrude B. Elion, Henry S. Friedman, Sharon M. Castellino, Darell D. Bigner, E. T. Ong, Robert L. Page, S. L. Marcelli
Publikováno v:
British Journal of Cancer
Flunarizine, a diphenylpiperazine calcium channel blocker, is known to increase tumor blood flow. It also interferes with calmodulin function, repair of DNA damage and drug resistance associated with P-glycoprotein. Flunarizine was tested for its abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958ddee8e9d4bff7dc3f0195a777a1b4
https://doi.org/10.1038/bjc.1995.230
https://doi.org/10.1038/bjc.1995.230
Autor:
Michael L. Graham, Gertrude B. Elion, R H Aaron, Darell D. Bigner, Henry S. Friedman, O M Colvin, Stephen T. Keir
Publikováno v:
Cancer Chemotherapy and Pharmacology. 35:127-131
We evaluated the antitumor activity of busulfan against a panel of tumor cell lines and xenografts in athymic nude mice derived from childhood high-grade glioma, adult high-grade glioma, ependymoma, and medulloblastoma. Busulfan displayed similar act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd2d091a01e2609e434c1e7eecb3101
https://doi.org/10.1007/bf00686634
https://doi.org/10.1007/bf00686634