Three-Dimensional Explant Platform for Studies on Choroid Plexus Epithelium

Autor: Natalia Petersen, Lola Torz, Kristian H. Reveles Jensen, Gertrud Malene Hjortø, Katja Spiess, Mette Marie Rosenkilde

Publikováno v: Frontiers in Cellular Neuroscience, Vol 14 (2020)

The choroid plexus (CP) plays a major role in controlling the entry of substances and immune cells into the brain as it forms the blood-cerebrospinal fluid barrier (BCSFB) in the brain ventricles. Dysregulated immune cell trafficking through the epit

Externí odkaz: https://doaj.org/article/dd16803e49bb4ad0b12399dfcd5e77a7

GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

Autor: Sine P. Schiellerup, Gertrud Malene Hjortø, Mette M. Rosenkilde, Florent Xavier Smit, Olav Larsen, Bolette Hartmann, Thor C. Møller, C. Christiansen, Jens J. Holst, Wijnand J.C. van der Velden, Hans Bräuner-Osborne, Thomas M. Frimurer

Publikováno v: ACS Pharmacol Transl Sci

[Image: see text] Biased ligands that selectively confer activity in one pathway over another are pharmacologically important because biased signaling may reduce on-target side effects and improve drug efficacy. Here, we describe an N-terminal modifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1b2b60a588622bae14728766e1f217
https://doi.org/10.1021/acsptsci.0c00193

Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21

Autor: Andy Chevigné, Michael B. Dwinell, Gertrud Malene Hjortø, Martyna Szpakowska, Natasha A. Moussouras, Brian F. Volkman, Mette M. Rosenkilde, Francis C. Peterson

Publikováno v: Biochemistry

The chemokines CCL21 and CCL19, through binding of their cognate receptor CCR7, orchestrate lymph node homing of dendritic cells and naïve T cells. CCL21 differs from CCL19 via an unstructured 32 residue C-terminal domain. Previously described roles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f4fed7c3dd9ce994e29f61f2ce7109
https://doi.org/10.1021/acs.biochem.0c00047

Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer

Autor: Astrid Sissel Jørgensen, Mette M. Rosenkilde, Gertrud Malene Hjortø, Emma Probst Brandum

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8340, p 8340 (2021)

Chemotactic cytokines—chemokines—control immune cell migration in the process of initiation and resolution of inflammatory conditions as part of the body’s defense system. Many chemokines also participate in pathological processes leading up to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b92619010fe90823178faa32fabcf4d
https://pubmed.ncbi.nlm.nih.gov/34361107

The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

Autor: Natasha A. Moussouras, Peter Johannes Holst, Brian F. Volkman, Christopher T. Veldkamp, Jeppe Malthe Mikkelsen, Zhang Yang, Frederik Vilhardt, Kristoffer L. Egerod, Katharina Lahl, Emma Probst Brandum, Mette M. Rosenkilde, Per H. Basse, Yen Hsi Chen, Christoffer K. Goth, Gertrud Malene Hjortø, Klaudia A. Orfin, Pawel Kalinski, Astrid Sissel Jørgensen, Michael B. Dwinell, Ditte Rahbæk Boilesen

Publikováno v: Jorgensen, A S, Brandum, E P, Mikkelsen, J M, Orfin, K A, Boilesen, D R, Egerod, K L, Moussouras, N A, Vilhardt, F, Kalinski, P, Basse, P, Chen, Y-H, Yang, Z, Dwinell, M B, Volkman, B F, Veldkamp, C T, Holst, P J, Lahl, K, Goth, C K, Rosenkilde, M M & Hjorto, G M 2021, ' The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus ', Cellular and Molecular Life Sciences, vol. 78, pp. 6963-6978 . https://doi.org/10.1007/s00018-021-03930-7
Cellular and Molecular Life Sciences

The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant compared to CCL19. Here we show that the 41-amino acid positively charged peptide, released th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0dd3d59f2ffef71bf371daee644900
https://curis.ku.dk/portal/da/publications/the-cterminal-peptide-of-ccl21-drastically-augments-ccl21-activity-through-the-dendritic-cell-lymph-node-homing-receptor-ccr7-by-interaction-with-the-receptor-nterminus(75fed330-7fae-4e10-a0b1-7fbac9b559e0).html