Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Gertrud Kortman"'
Autor:
Tobias Ackermann, Hidde R. Zuidhof, Christine Müller, Gertrud Kortman, Martijn G.S. Rutten, Mathilde J.C. Broekhuis, Mohamad Amr Zaini, Götz Hartleben, Cornelis F. Calkhoven
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101726- (2023)
Objective: Cancer cells use glycolysis for generation of metabolic intermediates and ATP needed for cell growth and proliferation. The transcription factor C/EBPβ-LIP stimulates glycolysis and mitochondrial respiration in cancer cells. We initially
Externí odkaz:
https://doaj.org/article/e7845cf038514e76a8bcc1de52b05e93
Autor:
Britt A. Sterken, Tobias Ackermann, Christine Müller, Hidde R. Zuidhof, Gertrud Kortman, Alejandra Hernandez-Segura, Mathilde Broekhuis, Diana Spierings, Victor Guryev, Cornelis F. Calkhoven
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract The transcription factor C/EBPβ is a master regulator of mammary gland development and tissue remodelling during lactation. The CEBPB-mRNA is translated into three distinct protein isoforms named C/EBPβ-LAP1, -LAP2 and -LIP that are functi
Externí odkaz:
https://doaj.org/article/053bf9612c99412689ab061e5d8d63d2
Autor:
Christine Müller, Laura M Zidek, Sabrina Eichwald, Gertrud Kortman, Mirjam H Koster, Cornelis F Calkhoven
Publikováno v:
eLife, Vol 11 (2022)
Chronic obesity is correlated with severe metabolic and cardiovascular diseases as well as with an increased risk for developing cancers. Obesity is usually characterized by fat accumulation in enlarged – hypertrophic – adipocytes that are a sour
Externí odkaz:
https://doaj.org/article/64bcc64988804739878871afa33841a6
Autor:
Mohamad A. Zaini, Christine Müller, Tristan V. de Jong, Tobias Ackermann, Götz Hartleben, Gertrud Kortman, Karl-Heinz Gührs, Fabrizia Fusetti, Oliver H. Krämer, Victor Guryev, Cornelis F. Calkhoven
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 497-511 (2018)
Summary: Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription factors that regulate gene expression and thereby cause changes
Externí odkaz:
https://doaj.org/article/b89c785701114568b66cb56f03f0941a
Autor:
Christine Müller, Laura M Zidek, Tobias Ackermann, Tristan de Jong, Peng Liu, Verena Kliche, Mohamad Amr Zaini, Gertrud Kortman, Liesbeth Harkema, Dineke S Verbeek, Jan P Tuckermann, Julia von Maltzahn, Alain de Bruin, Victor Guryev, Zhao-Qi Wang, Cornelis F Calkhoven
Publikováno v:
eLife, Vol 7 (2018)
Ageing is associated with physical decline and the development of age-related diseases such as metabolic disorders and cancer. Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signa
Externí odkaz:
https://doaj.org/article/b7abb0080c274a6897de4c882258f497
Autor:
Izabella Slezak-Prochazka, Joost Kluiver, Debora de Jong, Gertrud Kortman, Nancy Halsema, Sibrand Poppema, Bart-Jan Kroesen, Anke van den Berg
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76647 (2013)
Processing of miRNAs occurs simultaneous with the transcription and splicing of their primary transcripts. For the small subset of exonic miRNAs it is unclear if the unspliced and/or spliced transcripts are used for miRNA biogenesis. We assessed endo
Externí odkaz:
https://doaj.org/article/e2874de8a1604f51aa25bdf687459001
Autor:
Martijn G S Rutten, Mathilde J.C. Broekhuis, Tobias Ackermann, Gertrud Kortman, Mohamad A. Zaini, Cornelis F. Calkhoven, Götz Hartleben, Hidde R. Zuidhof
Oncogene-induced metabolic reprograming supports cell growth and proliferation. Yet, it also links cancer cell survival to certain metabolic pathways and nutrients. In order to synthesise amino acids and nucleotidesde novofor growth and proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ac7c0b7e1785911f954090c697d490
https://doi.org/10.1101/2020.10.09.333104
https://doi.org/10.1101/2020.10.09.333104
Autor:
Tineke van der Sluis, Arjan Diepstra, Jasper A. Koerts, Anke van den Berg, Klaas Kok, Gertrud Kortman, Lydia Visser, Joost Kluiver, Marian Bulthuis, Bea Rutgers, Annika Seitz, Debora de Jong, Agnieszka Dzikiewicz-Krawczyk
Publikováno v:
The American Journal of Pathology
The American Journal of Pathology, 188(5), 1289-1299. ELSEVIER SCIENCE INC
The American Journal of Pathology, 188(5), 1289-1299. ELSEVIER SCIENCE INC
miRNAs are small noncoding RNAs involved in the posttranscriptional regulation of gene expression. Deregulated miRNA levels have been linked to Burkitt lymphoma (BL) pathogenesis. To date, the number of known pathogenesis-related miRNA-target gene in
Autor:
Tristan V. de Jong, Cornelis F. Calkhoven, Karl-Heinz Gührs, Mohamad A. Zaini, Oliver H. Krämer, Victor Guryev, Götz Hartleben, Christine Müller, Gertrud Kortman, Fabrizia Fusetti, Tobias Ackermann
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 497-511 (2018)
Cell reports, 22(2), 497-511. CELL PRESS
Cell reports, 22(2), 497-511. CELL PRESS
Summary: Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription factors that regulate gene expression and thereby cause changes
Autor:
Sabrina Eichwald, Christine Müller, René Winkler, Cornelis F. Calkhoven, Zhao-Qi Wang, Christian Kosan, Laura M Zidek, Andreas Krämer, Gertrud Kortman, Joost Kluiver, Anke van den Berg, Iver Petersen, Heiko Schimmel, Carsten Dornblut, Götz Hartleben
Publikováno v:
The EMBO journal, 37(21)
The EMBO Journal
The EMBO Journal, 37(21):98589. Wiley
The EMBO Journal
The EMBO Journal, 37(21):98589. Wiley
The tuberous sclerosis complex (TSC) 1/2 is a negative regulator of the nutrient‐sensing kinase mechanistic target of rapamycin complex (mTORC1), and its function is generally associated with tumor suppression. Nevertheless, biallelic loss of funct