Zobrazeno 1 - 10 of 78 pro vyhledávání: '"Gertraud W. Robinson"'
1
Akademický článek
Loss of STAT1 from Mouse Mammary Epithelium Results in an Increased Neu-Induced Tumor Burden
Autor: Peter J. Klover, William J. Muller, Gertraud W. Robinson, Ruth M. Pfeiffer, Daisuke Yamaji, Lothar Hennighausen
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 11, Pp 899-905 (2010)
Type I and type II classes of interferons (IFNs) signal through the JAK/STAT1 pathway and are known to be important in adaptive and innate immune responses and in protection against tumors. Although STAT1 is widely considered a tumor suppressor, it r
Externí odkaz: https://doaj.org/article/c87b861932294890a94d2e77ee244fdd
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7
Akademický článek
Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions
Autor: Alejandro Villarino, Arian Laurence, Gertraud W Robinson, Michael Bonelli, Barbara Dema, Behdad Afzali, Han-Yu Shih, Hong-Wei Sun, Stephen R Brooks, Lothar Hennighausen, Yuka Kanno, John J O'Shea
Publikováno v: eLife, Vol 5 (2016)
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain. Using mouse models of paral
Externí odkaz: https://doaj.org/article/8af0f5efd04c4cec9fea78be48111138
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8
The STAT5-regulated miR-193b locus restrains mammary stem and progenitor cell activity and alveolar differentiation
Autor: Seung Jin Jang, Yonatan Feuermann, Lothar Hennighausen, Gertraud W. Robinson, Keunsoo Kang, Kyung Hyun Yoo
Publikováno v: Developmental Biology. 395(2):245-254
The transcription factor STAT5 mediates prolactin signaling and controls functional development of mammary tissue during pregnancy. This study has identified the miR-193b locus, also encoding miRNAs 365-1 and 6365, as a STAT5 target in mammary epithe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b388d9febf18c76bfe1b36fb09ab7c
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9
Mammary-Specific Gene Activation Is Defined by Progressive Recruitment of STAT5 during Pregnancy and the Establishment of H3K4me3 Marks
Autor: Keunsoo Kang, Kyung Hyun Yoo, Lothar Hennighausen, Daisuke Yamaji, Gertraud W. Robinson
Publikováno v: Molecular and Cellular Biology. 34:464-473
Differentiation of mammary secretory epithelium during pregnancy is characterized by sequential activation of genes over several orders of magnitude. Although the transcription factor STAT5 is key to alveolar development, it is not clear to what exte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d3758b96b29d6313d8960a1d7e6bf0
https://doi.org/10.1128/mcb.00988-13
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10
Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration
Autor: Lothar Hennighausen, Daisuke Yamaji, Keunsoo Kang, Gertraud W. Robinson
Publikováno v: Nucleic Acids Research
The transcription factors Signal Transducer and Activator of Transcription (STAT) 5A/B mediate prolactin-induced mammary development during pregnancy. However, it is not clear how the different processes, expansion and maturation of alveolar precurso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7fc161c35b3c743026cb9b77d2a060
https://doi.org/10.1093/nar/gks1310
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