Výsledky vyhledávání - "Gertraud W. Robinson"

Akademický článek

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

Autor: Alejandro Villarino, Arian Laurence, Gertraud W Robinson, Michael Bonelli, Barbara Dema, Behdad Afzali, Han-Yu Shih, Hong-Wei Sun, Stephen R Brooks, Lothar Hennighausen, Yuka Kanno, John J O'Shea

Publikováno v: eLife, Vol 5 (2016)

The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain. Using mouse models of paral

Externí odkaz: https://doaj.org/article/8af0f5efd04c4cec9fea78be48111138

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Akademický článek

Loss of STAT1 from Mouse Mammary Epithelium Results in an Increased Neu-Induced Tumor Burden

Autor: Peter J. Klover, William J. Muller, Gertraud W. Robinson, Ruth M. Pfeiffer, Daisuke Yamaji, Lothar Hennighausen

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 11, Pp 899-905 (2010)

Type I and type II classes of interferons (IFNs) signal through the JAK/STAT1 pathway and are known to be important in adaptive and innate immune responses and in protection against tumors. Although STAT1 is widely considered a tumor suppressor, it r

Externí odkaz: https://doaj.org/article/c87b861932294890a94d2e77ee244fdd

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Akademický článek

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

Autor: Yonatan Feuermann, Keunsoo Kang, Avi Shamay, Gertraud W Robinson, Lothar Hennighausen

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85123 (2014)

Development of mammary alveolar epithelium during pregnancy is controlled by prolactin, through the transcription factors STAT5A/B that activate specific sets of target genes. Here we asked whether some of STAT5's functions are mediated by microRNAs.

Externí odkaz: https://doaj.org/article/d43b345da6e8488e99e1ec368fe87a7d

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Akademický článek

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

Autor: Ji-Yeon Lee, Heike Muenzberg, Oksana Gavrilova, Jacquelyn A Reed, Darlene Berryman, Eneida C Villanueva, Gwendolyn W Louis, Gina M Leinninger, Stefano Bertuzzi, Randy J Seeley, Gertraud W Robinson, Martin G Myers, Lothar Hennighausen

Publikováno v: PLoS ONE, Vol 3, Iss 2, p e1639 (2008)

Signal transducers and activators of transcription (STATs) are critical components of cytokine signaling pathways. STAT5A and STAT5B (STAT5), the most promiscuous members of this family, are highly expressed in specific populations of hypothalamic ne

Externí odkaz: https://doaj.org/article/280816b9ef87450aaf7fb5fa2b12ca4b

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The STAT5-regulated miR-193b locus restrains mammary stem and progenitor cell activity and alveolar differentiation

Autor: Seung Jin Jang, Yonatan Feuermann, Lothar Hennighausen, Gertraud W. Robinson, Keunsoo Kang, Kyung Hyun Yoo

Publikováno v: Developmental Biology. 395(2):245-254

The transcription factor STAT5 mediates prolactin signaling and controls functional development of mammary tissue during pregnancy. This study has identified the miR-193b locus, also encoding miRNAs 365-1 and 6365, as a STAT5 target in mammary epithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b388d9febf18c76bfe1b36fb09ab7c

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