Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gertraud Koellner"'
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 60:1417-1424
Purine-nucleoside phosphorylase (PNP) deficiency in humans leads to inhibition of the T-cell response. Potent membrane-permeable inhibitors of this enzyme are therefore considered to be potential immunosuppressive agents. The binary complex of the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcce119b92601d54d71c41255db53456
https://doi.org/10.1107/s0907444904013861
https://doi.org/10.1107/s0907444904013861
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 22:1699-1702
The crystal structure at 2.05 A resolution of calf spleen PNP complexed with stoichiometric concentration of acyclic nucleoside phosphonate inhibitor, 2,6-diamino-(S)-9-[2-(phosphonomethoxy)propyl]purine, in a new space group P2(1)2(1)2(1) which cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f377125ea9f5d0b81d065c69c1922a67
https://doi.org/10.1081/ncn-120023117
https://doi.org/10.1081/ncn-120023117
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 22:1695-1698
Binding enthalpies, dissociation constants and stoichiometry of binding for interaction of trimeric calf spleen and Cellulomonas sp. purine nucleoside phosphorylases with their ground state analogues (substrates and inhibitors) were studied by calori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784efcee953677a05c023437756546dd
https://doi.org/10.1081/ncn-120023116
https://doi.org/10.1081/ncn-120023116
Autor:
Agnieszka Bzowska, Wolfram Saenger, Marija Luić, Gertraud Koellner, Janusz Stepinski, Beata Wielgus-Kutrowska, Thomas Steiner
Publikováno v:
Journal of Molecular Biology. 315:351-371
The crystal structure of the ternary complex of hexameric purine nucleoside phosphorylase (PNP) from Escherichia coli with formycin A derivatives and phosphate or sulphate ions is determined at 2.0 Angstrom resolution. The hexamer is found as a trime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a45b7a2cc778e8fa39ae224ccb41f05
https://doi.org/10.1006/jmbi.2001.5211
https://doi.org/10.1006/jmbi.2001.5211
Autor:
Gertraud Koellner, Thomas Steiner
Publikováno v:
Journal of Molecular Biology. 305:535-557
A comprehensive structural analysis of X--H...pi hydrogen bonding in proteins is performed based on 592 published high-resolution crystal structures (< or = 1.6 A). All potential donors and acceptors are considered, including acidic C--H groups. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02f3dcec97ccab2aac3ba9df2c0ce599
https://doi.org/10.1006/jmbi.2000.4301
https://doi.org/10.1006/jmbi.2000.4301
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 57:30-36
The calf spleen purine nucleoside phosphorylase (PNP) ternary complex with an N(7)-acycloguanosine inhibitor and a phosphate ion has been crystallized in the cubic space group P2(1)3, with unit-cell parameter a = 94.11 Angstrom and one monomer per as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87845e2278ab3bbbc7ff2523c3e2ddb2
https://doi.org/10.1107/s0907444900014402
https://doi.org/10.1107/s0907444900014402
Autor:
Charles B. Millard, Thomas Steiner, Israel Silman, Gertraud Koellner, Joel L. Sussman, Gitay Kryger
Publikováno v:
Journal of Molecular Biology. 296:713-735
Buried water molecules and the water molecules in the active-site gorge are analyzed for five crystal structures of acetylcholinesterase from Torpedo californica in the resolution range 2.2-2.5 A (native enzyme, and four inhibitor complexes). A total
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::879ce830e363e8e94eee501fbb62ba2d
https://doi.org/10.1006/jmbi.1999.3468
https://doi.org/10.1006/jmbi.1999.3468
Autor:
Antoine M. M. Schreurs, Thomas Steiner, Gertraud Koellner, R. Srinivasan, Kathavarayan Subramanian, S. Suresh Kumar, K. Rajagopalan, Jan Kroon
Publikováno v:
Journal of Molecular Structure. 448:51-55
In the crystal structure of N-(4-methylphenyl)-N-prop-2-ynylurea, urea dimers are formed which are linked by cooperative NH···CCH···O hydrogen bonds, leading to an infinite two-dimensional hydrogen bond network.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d4a64b0754d5f07e7858cbf92a787a
https://doi.org/10.1016/s0022-2860(98)00336-6
https://doi.org/10.1016/s0022-2860(98)00336-6
Publikováno v:
Journal of Molecular Structure. 444:21-27
The X-ray crystal structure of 2-chloro-2′-deoxyadenosine was determined at low temperature [space group orthorhombic P21212, a = 7.493(6), b = 16.894(4), c = 9.065(4) →A, V = 1147.6(11) →A3, 4097 unique reflections, R = 0.050]. The ribose unit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70fe4c81c5d91974fd5b2858a62b72c2
https://doi.org/10.1016/s0022-2860(97)00312-8
https://doi.org/10.1016/s0022-2860(97)00312-8
Publikováno v:
Journal of Chemical Crystallography. 28:149-152
The X-ray crystal structure of 1,6-bis(N-cyano-p-methoxy-anilino)-2,4-hexadiyne, C22H18N4O2, is determined. The crystal packing is dominated by phenyl stacking interactions. Weak C–H···N hydrogen bonds help align the molecules. C–H···π hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a875ffad0a091c6d46f07b107b8a99
https://doi.org/10.1023/a:1022450015853
https://doi.org/10.1023/a:1022450015853