Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Gerta Hoxhaj"'
Autor:
Dong-Min Yu, Jiawei Zhao, Eunice E. Lee, Dohun Kim, Ruchika Mahapatra, Elysha K. Rose, Zhiwei Zhou, Calvin Hosler, Abdullah El Kurdi, Jun-Yong Choe, E. Dale Abel, Gerta Hoxhaj, Kenneth D. Westover, Raymond J. Cho, Jeffrey B. Cheng, Richard C. Wang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
The facilitative GLUT1 and GLUT3 hexose transporters are expressed abundantly in macrophages, but whether they have distinct functions remains unclear. We confirmed that GLUT1 expression increased after M1 polarization stimuli and found that GLUT3 ex
Externí odkaz:
https://doaj.org/article/9c866e5d91dc452ebe9f5a92286a3c61
Autor:
Janna L. Crossley, Sonya Ostashevskaya-Gohstand, Stefano Comazzetto, Jessica S. Hook, Lei Guo, Neda Vishlaghi, Conan Juan, Lin Xu, Alexander R. Horswill, Gerta Hoxhaj, Jessica G. Moreland, Robert J. Tower, Benjamin Levi
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that unde
Externí odkaz:
https://doaj.org/article/de41bdacaa51470f9d19876b0d0fa043
Autor:
Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers. Here, the authors show that purine depletion induces s
Externí odkaz:
https://doaj.org/article/e65828f4fe7b450899c62fcdaa40754f
Autor:
Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell, Aaron M. Hosios, Maria Osipovich, Margaret E. Torrence, James R. Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D. Manning
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110824- (2022)
Summary: The tuberous sclerosis complex (TSC) 1 and 2 proteins associate with TBC1D7 to form the TSC complex, which is an essential suppressor of mTOR complex 1 (mTORC1), a ubiquitous driver of cell and tissue growth. Loss-of-function mutations in TS
Externí odkaz:
https://doaj.org/article/a8d11e480e6448ff83b8e02eb07d3281
Autor:
Vanessa Byles, Yann Cormerais, Krystle Kalafut, Victor Barrera, James E. Hughes Hallett, Shannan Ho Sui, John M. Asara, Christopher M. Adams, Gerta Hoxhaj, Issam Ben-Sahra, Brendan D. Manning
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101309- (2021)
Objective: The mechanistic target of rapamycin complex 1 (mTORC1) is dynamically regulated by fasting and feeding cycles in the liver to promote protein and lipid synthesis while suppressing autophagy. However, beyond these functions, the metabolic r
Externí odkaz:
https://doaj.org/article/9bc1252e0f6b4fe8816ee31294ba42c1
Autor:
Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1331-1346 (2017)
Summary: Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis. We find that the mTORC1 pathway i
Externí odkaz:
https://doaj.org/article/2f396a16f2994d80bba511cc91261878
Autor:
Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh
Publikováno v:
eLife, Vol 5 (2016)
The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated E3 ubiquitin ligase ZNRF2
Externí odkaz:
https://doaj.org/article/22e15996b1d34e3eb9da975e48348923
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73327 (2013)
Insulin receptor substrate 1 (IRS1) and IRS2 are well-characterized adapter proteins that relay signals from receptor tyrosine kinases to downstream components of signalling pathways. In contrast, the function of IRS4 is not well understood. IRS4 ove
Externí odkaz:
https://doaj.org/article/5d0df97bb66b467aa2d53a4789674f91
Autor:
Ayaz Najafov, Tuncay Seker, Ipek Even, Gerta Hoxhaj, Osman Selvi, Duygu Esen Ozel, Ahmet Koman, Necla Birgül-İyison
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37013 (2012)
Wnt/β-catenin signalling pathway plays important roles in embryonic development and carcinogenesis. Overactivation of the pathway is one of the most common driving forces in major cancers such as colorectal and breast cancers. The downstream effecto
Externí odkaz:
https://doaj.org/article/209912e2be2441afa0af930f9b18ade5
Autor:
Gerta Hoxhaj, Ed Reznik
Publikováno v:
Nature Metabolism.