Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gerta Cami-Kobeci"'
Publikováno v:
Brain Sciences, Vol 10, Iss 11, p 807 (2020)
The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson’s dise
Externí odkaz:
https://doaj.org/article/f26136ecdbd14ad886ac6822ce46305a
Autor:
Vinod Kumar, Willma E. Polgar, Gerta Cami-Kobeci, Mark P. Thomas, Taline V. Khroyan, Lawrence Toll, Stephen M. Husbands
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and delta (DOP) opioid receptors and nociceptin/orphanin FQ peptide (
Externí odkaz:
https://doaj.org/article/58e4bb6f303a4aafa9e71da6f7462d7d
Autor:
Lisa R. Gerak, David R. Maguire, Gerta Cami-Kobeci, Keith M. Olson, John R. Traynor, Stephen M. Husbands, Charles P. France, Lisette Acevedo, Barbara Belli, Peter Flynn
Publikováno v:
Behavioural pharmacology. 33(6)
Drugs targeting mu opioid receptors are the mainstay of clinical practice for treating moderate-to-severe pain. While they can offer excellent analgesia, their use can be limited by adverse effects, including constipation, respiratory depression, tol
Autor:
Gerta Cami-Kobeci, Stephen M. Husbands, Huiping Ding, Paul W. Czoty, Norikazu Kiguchi, Mei-Chuan Ko, Lawrence Toll, Heather B. DeLoid, Devki Sukhtankar, Fang-Chi Hsu
Publikováno v:
Br J Anaesth
Kiguchi, N, Ding, H, Cami-Kobeci, G, Sukhtankar, D D, Czoty, P W, DeLoid, H B, Hsu, F-C, Toll, L, Husbands, S & Ko, M C 2019, ' BU10038 as a safe opioid analgesic with fewer side effects after systemic and intrathecal administration in primates ', British Journal of Anaesthesia, vol. 122, no. 6, pp. e146-e156 . https://doi.org/10.1016/j.bja.2018.10.065
Kiguchi, N, Ding, H, Cami-Kobeci, G, Sukhtankar, D D, Czoty, P W, DeLoid, H B, Hsu, F-C, Toll, L, Husbands, S & Ko, M C 2019, ' BU10038 as a safe opioid analgesic with fewer side effects after systemic and intrathecal administration in primates ', British Journal of Anaesthesia, vol. 122, no. 6, pp. e146-e156 . https://doi.org/10.1016/j.bja.2018.10.065
Background The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and nociceptin/orphanin FQ peptide
Autor:
Andrea Cippitelli, Madeline Martinez, Gilles Zribi, Gerta Cami-Kobeci, Stephen M. Husbands, Lawrence Toll
Publikováno v:
Neuropharmacology
Cippitelli, A, Martinez, M, Zribi, G, Cami-Kobeci, G, Husbands, S M & Toll, L 2022, ' PPL-138 (BU10038) : A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats ', Neuropharmacology, vol. 211, 109045 . https://doi.org/10.1016/j.neuropharm.2022.109045
Cippitelli, A, Martinez, M, Zribi, G, Cami-Kobeci, G, Husbands, S M & Toll, L 2022, ' PPL-138 (BU10038) : A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats ', Neuropharmacology, vol. 211, 109045 . https://doi.org/10.1016/j.neuropharm.2022.109045
The search for new and effective treatments for cocaine use disorder (CUD) is a priority. We determined whether PPL-138 (BU10038), a compound with partial agonist activity at both nociceptin opioid peptide (NOP) and mu-opioid receptors, reduces cocai
Publikováno v:
Chaudhry, Z L, Klenja, D, Janjua, N, Cami-Kobeci, G & Ahmad, B Y 2020, ' COVID-19 and Parkinson’s disease : Shared inflammatory pathways under oxidative stress ', Brain Sciences, vol. 10, no. 11, 807 . https://doi.org/10.3390/brainsci10110807
Brain Sciences, Vol 10, Iss 807, p 807 (2020)
Brain Sciences
Volume 10
Issue 11
Brain Sciences, Vol 10, Iss 807, p 807 (2020)
Brain Sciences
Volume 10
Issue 11
The current coronavirus pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a serious global health crisis. It is a major concern for individuals living with chronic disorders such as Parkinson&rsquo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a30da08b12ff98d509c8c0b2be6fc3a
https://research-information.bris.ac.uk/en/publications/41772486-b863-402b-9d3d-b895ba101f6a
https://research-information.bris.ac.uk/en/publications/41772486-b863-402b-9d3d-b895ba101f6a
Autor:
Gerta Cami-Kobeci, Paul W. Czoty, Phillip M. Epperly, Stephen M. Husbands, Shawn M. Flynn, Mei-Chuan Ko, April T. Davenport
Publikováno v:
Flynn, S M, Epperly, P M, Davenport, A T, Cami-Kobeci, G, Husbands, S M, Ko, M C & Czoty, P W 2019, ' Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys ', Neuropsychopharmacology, vol. 44, no. 8, pp. 1476-1484 . https://doi.org/10.1038/s41386-019-0390-z
Neuropsychopharmacology
Neuropsychopharmacology
Alcohol use disorder (AUD) persists as a devastating public health problem; widely effective pharmacological treatments are needed. Evidence from rodent models suggests that stimulating brain receptors for the neuropeptide nociceptin/orphanin FQ (NOP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a09f5692e28520110d3239a03bf28e4
https://purehost.bath.ac.uk/ws/files/191604266/2019_Flynnetal_R1.pdf
https://purehost.bath.ac.uk/ws/files/191604266/2019_Flynnetal_R1.pdf
Publikováno v:
The FASEB Journal. 33
Autor:
Mariana Spetea, Tanila Ben Haddou, Gerta Cami-Kobeci, Radzisław Kordek, Stephen M. Husbands, Agata Jarmuż, Maciej Sałaga, Milena Padysz, Marta Zielińska, Jakub Fichna
Publikováno v:
European Journal of Pharmacology. 765:582-590
Endogenous opioid and nociceptin systems are widely distributed in the gastrointestinal tract where they seem to play a crucial role in maintaining the intestinal homeostasis. The aim of our study was to assess whether activation of nociceptin (NOP)
Autor:
Taline V. Khroyan, Lawrence Toll, Jinhua Wu, Stephen M. Husbands, Willma E. Polgar, Gerta Cami-Kobeci, Nikoletta Fotaki
Publikováno v:
British Journal of Pharmacology. 172:668-680
BACKGROUND AND PURPOSE Buprenorphine is a potent analgesic with high affinity at μ, δ and κ and moderate affinity at nociceptin opioid (NOP) receptors. Nevertheless, NOP receptor activation modulates the in vivo activity of buprenorphine. Structur