Zobrazeno 1 - 10
of 73
pro vyhledávání: '"GertJan J L Kaspers"'
Autor:
Wim J E Tissing, Martha A Grootenhuis, Raphaële R L van Litsenburg, Gertjan J L Kaspers, Emily R Schwartz, Niki Rensen, Lindsay M H Steur, Reinoud Gemke, Natasha K A van Eijkelenburg, Inge M van der Sluis, Natasja Dors, Cor van den Bos
Publikováno v:
BMJ Open, Vol 13, Iss 10 (2023)
Objectives Health-related quality of life (HRQoL) is impaired in paediatric patients with acute lymphoblastic leukaemia (ALL). Over the past decades, ALL treatment has successfully been adjusted to the risk of relapse, which is now reflected by the s
Externí odkaz:
https://doaj.org/article/d8d4a6a2c4f94863bdf0805391a44a8f
Autor:
Irsan E Kooi, Berber M Mol, Maarten P G Massink, Marcus C de Jong, Pim de Graaf, Paul van der Valk, Hanne Meijers-Heijboer, Gertjan J L Kaspers, Annette C Moll, Hein Te Riele, Jacqueline Cloos, Josephine C Dorsman
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153323 (2016)
BACKGROUND:While RB1 loss initiates retinoblastoma development, additional somatic copy number alterations (SCNAs) can drive tumor progression. Although SCNAs have been identified with good concordance between studies at a cytoband resolution, accura
Externí odkaz:
https://doaj.org/article/a4e101cc4a1d4a9ebfd3f8e89c61b4f4
Autor:
Costa Bachas, Gerrit Jan Schuurhuis, C Michel Zwaan, Marry M van den Heuvel-Eibrink, Monique L den Boer, Eveline S J M de Bont, Zinia J Kwidama, Dirk Reinhardt, Ursula Creutzig, Valérie de Haas, Gertjan J L Kaspers, Jacqueline Cloos
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121730 (2015)
Development of relapse remains a problem for further improvements in the survival of pediatric AML patients. While virtually all patients show a good response to initial treatment, more patients respond poorly when treated at relapse. The cellular ch
Externí odkaz:
https://doaj.org/article/f2c2fd5f271c447aa5b3df572240735c
Autor:
Mahban Irandoust, Julian Alvarez Zarate, Isabelle Hubeek, Ellen M van Beek, Karin Schornagel, Aart J F Broekhuizen, Mercan Akyuz, Arjan A van de Loosdrecht, Ruud Delwel, Peter J Valk, Edwin Sonneveld, Pamela Kearns, Ursula Creutzig, Dirk Reinhardt, Eveline S J M de Bont, Eva A Coenen, Marry M van den Heuvel-Eibrink, C Michel Zwaan, Gertjan J L Kaspers, Jacqueline Cloos, Timo K van den Berg
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52143 (2013)
BackgroundRecent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, i
Externí odkaz:
https://doaj.org/article/4130b2e000fb4e6db767bbaff246bd5c
Autor:
Susanna J E Veringa, Dennis Biesmans, Dannis G van Vuurden, Marc H A Jansen, Laurine E Wedekind, Ilona Horsman, Pieter Wesseling, William Peter Vandertop, David P Noske, GertJan J L Kaspers, Esther Hulleman
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61512 (2013)
Pediatric high-grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPG), are the leading cause of cancer-related death in children. While it is clear that surgery (if possible), and radiotherapy are beneficial for treatment, the role
Externí odkaz:
https://doaj.org/article/01e687bccdfb483d9029fcb1ae9fd28e
Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment.
Autor:
Dannis G van Vuurden, Maryam Yazdani, Ingeborg Bosma, Aart J F Broekhuizen, Tjeerd J Postma, Jan J Heimans, Paul van der Valk, Eleonora Aronica, Bakhos A Tannous, Thomas Würdinger, Gertjan J L Kaspers, Jacqueline Cloos
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5953 (2009)
BACKGROUND: Glioblastoma multiforme (GBM) cells secrete large amounts of glutamate that can trigger AMPA-type glutamate receptors (AMPARs). This commonly results in Na(+) and Ca(2+)-permeability and thereby in excitotoxic cell death of the surroundin
Externí odkaz:
https://doaj.org/article/644353f91b474748a5148f3504aa7c0a
Autor:
A. Laura Nijstad, Wan-Yu Chu, Evelien de Vos-Kerkhof, Catherine F. Enters-Weijnen, Mirjam E. van de Velde, Gertjan J. L. Kaspers, Shelby Barnett, Gareth J. Veal, Arief Lalmohamed, C. Michel Zwaan, Alwin D. R. Huitema
Publikováno v:
Pharmaceutical Research, 39(10), 2487-2495. Springer New York
Nijstad, A L, Chu, W-Y, de Vos-Kerkhof, E, Enters-Weijnen, C F, van de Velde, M E, Kaspers, G J L, Barnett, S, Veal, G J, Lalmohamed, A, Zwaan, C M & Huitema, A D R 2022, ' A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children ', Pharmaceutical Research, vol. 39, no. 10, pp. 2487-2495 . https://doi.org/10.1007/s11095-022-03364-1
Nijstad, A L, Chu, W-Y, de Vos-Kerkhof, E, Enters-Weijnen, C F, van de Velde, M E, Kaspers, G J L, Barnett, S, Veal, G J, Lalmohamed, A, Zwaan, C M & Huitema, A D R 2022, ' A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children ', Pharmaceutical Research, vol. 39, no. 10, pp. 2487-2495 . https://doi.org/10.1007/s11095-022-03364-1
Background Vincristine, a chemotherapeutic agent that extensively binds to β-tubulin, is commonly dosed at 1.4–2.0 mg/m2 capped at 2 mg. For infants, doses vary from 0.025–0.05 mg/kg or 50–80% of the mg/m2 dose. However, evidence for lower dos
Autor:
Nur Melani Sari, Sultan Devansyah, Ismiana Modjaningrat, Nur Suryawan, Susi Susanah, Lulu Rakhmillah, Kurnia Wahyudi, Gertjan J. L. Kaspers
Publikováno v:
Pediatric Blood and Cancer, 70(4):e30192. Wiley-Liss Inc.
Sari, N M, Devansyah, S, Modjaningrat, I, Suryawan, N, Susanah, S, Rakhmillah, L, Wahyudi, K & Kaspers, G J L 2023, ' Type of cancer and complementary and alternative medicine are determinant factors for the patient delay experienced by children with cancer : A study in West Java, Indonesia ', Pediatric Blood and Cancer, vol. 70, no. 4, e30192 . https://doi.org/10.1002/pbc.30192
Sari, N M, Devansyah, S, Modjaningrat, I, Suryawan, N, Susanah, S, Rakhmillah, L, Wahyudi, K & Kaspers, G J L 2023, ' Type of cancer and complementary and alternative medicine are determinant factors for the patient delay experienced by children with cancer : A study in West Java, Indonesia ', Pediatric Blood and Cancer, vol. 70, no. 4, e30192 . https://doi.org/10.1002/pbc.30192
Introduction: Most pediatric cancer patients in developing countries present at an advanced stage due to delayed diagnosis, being an important barrier to effective care. The objective of this study was to evaluate the associated factor of patient del
Autor:
Katja C E Drechsel, Maxime C F Pilon, Francis Stoutjesdijk, Salena Meivis, Linda J Schoonmade, William Hamish B Wallace, Eline van Dulmen-den Broeder, Auke Beishuizen, Gertjan J L Kaspers, Simone L Broer, Margreet A Veening
Publikováno v:
Human Reproduction Update.
BACKGROUNDOwing to a growing number of young and adolescent Hodgkin lymphoma (HL) survivors, awareness of (long-term) adverse effects of anticancer treatment increases. The risk of impaired reproductive ability is of great concern given its impact on
Autor:
Elin Irestorm, Lindsay M. H. Steur, Gertjan J. L. Kaspers, Natasha K. A. Van Eijkelenburg, Inge M. Van der Sluis, Natasja Dors, Cor Van den Bos, Wim J. E. Tissing, Martha A. Grootenhuis, Raphaele R. L. Van Litsenburg
Publikováno v:
Supportive care in cancer, 31(1):1. Springer Verlag
Supportive Care in Cancer, 31(1):1. Springer Verlag
Irestorm, E, Steur, L M H, Kaspers, G J L, van Eijkelenburg, N K A, van der Sluis, I M, Dors, N, van den Bos, C, Tissing, W J E, Grootenhuis, M A & van Litsenburg, R R L 2023, ' Fatigue trajectories during pediatric ALL therapy are associated with fatigue after treatment : a national longitudinal cohort study ', Supportive Care in Cancer, vol. 31, no. 1, 1 . https://doi.org/10.1007/s00520-022-07456-x
Supportive Care in Cancer, 31(1):1. SPRINGER
Supportive Care in Cancer, 31(1):1. Springer Verlag
Irestorm, E, Steur, L M H, Kaspers, G J L, van Eijkelenburg, N K A, van der Sluis, I M, Dors, N, van den Bos, C, Tissing, W J E, Grootenhuis, M A & van Litsenburg, R R L 2023, ' Fatigue trajectories during pediatric ALL therapy are associated with fatigue after treatment : a national longitudinal cohort study ', Supportive Care in Cancer, vol. 31, no. 1, 1 . https://doi.org/10.1007/s00520-022-07456-x
Supportive Care in Cancer, 31(1):1. SPRINGER
Objective Fatigue is one of the most prevalent and distressing symptoms reported by survivors of childhood cancer. There is currently a lack of longitudinal studies on cancer-related fatigue, and especially on the relationship between the course of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ff752006745c8397610ce6412eb7de
https://pure.amc.nl/en/publications/fatigue-trajectories-during-pediatric-all-therapy-are-associated-with-fatigue-after-treatment(d3fefd12-4197-4d81-b915-ce2120fcc181).html
https://pure.amc.nl/en/publications/fatigue-trajectories-during-pediatric-all-therapy-are-associated-with-fatigue-after-treatment(d3fefd12-4197-4d81-b915-ce2120fcc181).html