Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum

Autor: Tineke Berkers, Dani Visscher, Gert S. Gooris, Joke A. Bouwstra

Publikováno v: Acta Dermato-Venereologica, Vol 98, Iss 4, Pp 421-427 (2018)

Previously, a skin barrier repair model was developed to examine the effect of formulations on the lipid properties of compromised skin. In this model, the lipid organization mimics that of several skin diseases with impaired skin barrier and less de

Externí odkaz: https://doaj.org/article/0d7040042a994993b296c01a690d2e11

The Importance of Free Fatty Chain Length on the Lipid Organization in the Long Periodicity Phase

Autor: Charlotte M. Beddoes, Denise E. Rensen, Gert S. Gooris, Marc Malfois, Joke A. Bouwstra

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7, p 3679 (2021)

The skin’s barrier ability is an essential function for terrestrial survival, which is controlled by intercellular lipids within the stratum corneum (SC) layer. In this barrier, free fatty acids (FFAs) are an important lipid class. As seen in infla

Externí odkaz: https://doaj.org/article/401b5c7408934b5db69780c8541a5d17

Lipid mixtures prepared with well-defined synthetic ceramides closely mimic the unique stratum corneum lipid phase behavior

Autor: Miranda W. de Jager, Gert S. Gooris, Maria Ponec, Joke A. Bouwstra

Publikováno v: Journal of Lipid Research, Vol 46, Iss 12, Pp 2649-2656 (2005)

Lipid lamellae present in the outermost layer of the skin, the stratum corneum, form the main barrier for the diffusion of molecules through the skin. The presence of a unique 13 nm lamellar phase and its high crystallinity are characteristic for the

Externí odkaz: https://doaj.org/article/d0c19711d98a438eaba2b547d1265534

The importance of ceramide headgroup for lipid localisation in skin lipid models

Autor: Charlotte M. Beddoes, Gert S. Gooris, David J. Barlow, M. Jayne Lawrence, Robert M. Dalgliesh, Marc Malfois, Bruno Demé, Joke A. Bouwstra

Publikováno v: 'Biochimica et Biophysica Acta (BBA)-Biomembranes ', vol: 1864, pages: 183886-1-183886-9 (2022)
BBA-Biomembranes, 1864(6)
Beddoes, C M, Gooris, G S, Barlow, D, Lawrence, J, Dalgliesh, R M, Malfois, M, Deme, B & Bouwstra, J A 2022, ' The importance of ceramide headgroup for lipid localisation in skin lipid models ', Biochimica et Biophysica Acta-Biomembranes, vol. 1864, no. 6, 183886 . https://doi.org/10.1016/j.bbamem.2022.183886

The stratum corneum's lipid matrix is a critical for the skin's barrier function and is primarily composed of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs). The lipids form a long periodicity phase (LPP), a unique trilayer unit cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc1863f9286fa88a34a013be86d564e
https://hdl.handle.net/1887/3281234

One Peptide for Them All: Gold Nanoparticles of Different Sizes Are Stabilized by a Common Peptide Amphiphile

Autor: Joke A. Bouwstra, Nico A. J. M. Sommerdijk, Gert S. Gooris, Aimee L. Boyle, Alexander Kros, Mark M. J. van Rijt, Elena A. Egorova

Publikováno v: ACS Nano
ACS Nano, 14(5), 5874-5886
ACS Nano, 14(5), 5874-5886. AMER CHEMICAL SOC
ACS Nano, 14(5), 5874-5886. American Chemical Society
ACS Nano, 14, 5, pp. 5874-5886
ACS Nano, 14, 5874-5886

The functionalization of gold nanoparticles (GNPs) with peptidic moieties can prevent their aggregation and facilitate their use for applications both in vitro and in vivo. To date, no peptide-based coating has been shown to stabilize GNPs larger tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c80a8f079983ed559c4ee2f049f6bf
https://doi.org/10.1021/acsnano.0c01021