Probing the Action of Permeation Enhancers Sodium Cholate and N-dodecyl-β-D-maltoside in a Porcine Jejunal Mucosal Explant System

Autor: E. Michael Danielsen, Gert H. Hansen

Publikováno v: Pharmaceutics, Vol 10, Iss 4, p 172 (2018)

The small intestinal epithelium constitutes a major permeability barrier for the oral administration of therapeutic drugs with poor bioavailability, and permeation enhancers (PEs) are required to increase the paracellular and/or transcellular uptake

Externí odkaz: https://doaj.org/article/05cb3e0cde854d3c972dce052f69db36

Short-term tissue permeability actions of dextran sulfate sodium studied in a colon organ culture system

Autor: E. Michael Danielsen, Alba De Haro Hernando, Jørgen Olsen, Mohammad Yassin, Elisabeth M. Danielsen, Gert H. Hansen, Karina Rasmussen

Publikováno v: Danielsen, E M, De Haro Hernando, A, Yassin, M, Rasmussen, K, Olsen, J, Hansen, G H & Danielsen, E M 2020, ' Short-term tissue permeability actions of dextran sulfate sodium studied in a colon organ culture system ', Tissue Barriers, vol. 8, no. 2, 1728165 . https://doi.org/10.1080/21688370.2020.1728165
Tissue Barriers
article-version (VoR) Version of Record

Dextran sulfate sodium (DSS)-induced colitis is the most commonly used animal model for inflammatory bowel diseases. However, the precise molecular action of DSS, in particular its initial effect on the epithelial tissue permeability, is still poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4011cd2d052d217e80de627f7a414d6f
https://curis.ku.dk/portal/da/publications/shortterm-tissue-permeability-actions-of-dextran-sulfate-sodium-studied-in-a-colon-organ-culture-system(b7f74e9c-5dcd-4f1c-aa35-88c4679a2169).html

Small molecule pinocytosis and clathrin-dependent endocytosis at the intestinal brush border: Two separate pathways into the enterocyte

Autor: E. Michael Danielsen, Gert H. Hansen

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:233-243

Pinocytosis at the small intestinal brush border was studied in postweaned porcine cultured mucosal explants, using the fluorescent polar probes Alexa hydrazide (AH, MW 570), Texas red dextran (TRD, MW ~ 3000), and Cascade blue dextran (CBD, MW ~ 10,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43eec1beb50b74d8e46bc8a91746d969
https://doi.org/10.1016/j.bbamem.2015.11.022

Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system

Autor: E. Michael Danielsen, Gert H. Hansen

Publikováno v: Tissue barriers. 5(3)

Intestinal permeation enhancers (PEs) are agents aimed to improve oral delivery of therapeutic drugs with poor bioavailability. The main permeability barrier for oral delivery is the intestinal epithelium, and PEs act to increase the paracellular and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97ff6db7f0882529c17b0b7c42224f9
https://pubmed.ncbi.nlm.nih.gov/28837408

IgG trafficking in the adult pig small intestine: one- or bidirectional transfer across the enterocyte brush border?

Autor: E. Michael Danielsen, Gert H. Hansen, Rebecca Möller

Publikováno v: Histochemistry and cell biology. 147(3)

Immunoglobulin G (IgG) transfer in opposite directions across the small intestinal brush border serves different purposes in early life and in adulthood. In the neonate, maternal IgG is taken up from the gut lumen into the blood, conferring passive i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad0eee9000c132a82daf7e4154e7098
https://pubmed.ncbi.nlm.nih.gov/27646280