Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis)

Autor: Jonathan Scott, Loredana Trevi, Hannah McNeil, Tom Ewen, Phil Mawson, David McDonald, Andrew Filby, Ranjit Lall, Katie Booth, Gert Boschman, Vesna Melkebeek, Gavin Perkins, Ronan McMullan, Daniel F McAuley, Iain J McCullagh, Timothy Walsh, Anthony Rostron, Manu Shankar-Hari, Paul Dark, A John Simpson, Andrew Conway Morris, Thomas P Hellyer

Publikováno v: Dark, P & Hellyer, T P 2022, ' Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use : protocol for an observational study (RISC-sepsis) ', BMJ Open, vol. 12, no. 12, e068321 . https://doi.org/10.1136/bmjopen-2022-068321
Scott, J, Trevi, L, McNeil, H, Ewen, T, Mawson, P, McDonald, D, Filby, A, Lall, R, Booth, K, Boschman, G, Melkebeek, V, Perkins, G, McMullan, R, McAuley, D F, McCullagh, I J, Walsh, T, Rostron, A, Shankar-Hari, M, Dark, P, Simpson, A J, Conway Morris, A & Hellyer, T P 2022, ' Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use : protocol for an observational study (RISC-sepsis) ', BMJ Open, vol. 12, no. 12, pp. e068321 . https://doi.org/10.1136/bmjopen-2022-068321

Peer reviewed: True
INTRODUCTION: Sepsis is characterised by a dysregulated immune response to infection, with exaggerated pro-inflammatory and anti-inflammatory responses. A predominant immunosuppressive profile affecting both innate and adapti

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Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation

Autor: D W James Keenan, Alistair I Roy, Ronan McMullan, Ashley Agus, Niall Anderson, Gert Boschman, Christopher Bassford, Stephen E Wright, Jonathan Scott, Anthony J. Rostron, A. John Simpson, Nicole M Robin, Cecilia O'Kane, Vanessa Linnett, Simon Baudouin, Ingeborg Welters, Jonathan Hulme, Susan A Bowett, Glenn Phair, Lydia M Emerson, Daniel F. McAuley, A Joy Allen, Julian Sonksen, Bronagh Blackwood, Paul Dark, Ross L Paterson, Kallirroi Kefala, Stephen Bonner, Gavin D. Perkins, Bryan Yates, Tina Van Den Broeck, Jennie Parker, Shondipon Laha, Timothy S. Walsh, Craig Spencer, Thomas P Hellyer, Suveer Singh, Jonathan Bannard-Smith, Andrew Conway Morris

Publikováno v: LANCET RESPIRATORY MEDICINE
Hellyer, T P, Mcauley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, Mcmullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, D J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine . https://doi.org/10.1016/S2213-2600(19)30367-4
Ann Transl Med
Hellyer, T P, McAuley, D, Walsh, T S, Anderson, N H, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C, Baudouin, S V, Paterson, R W, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N, Welters, I, Bassford, C, Yates, B, Spencer, C, Laha, S, Hulme, J, Bonner, S, Linnett, V C, Sonksen, J, van den Broeck, T, Boschman, G, Keenan, J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2019, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine, vol. 8, no. 2, pp. 182 . https://doi.org/10.1016/S2213-2600(19)30367-4
Hellyer, T P, McAuley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, DW J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine, vol. 8, no. 2, pp. 182-191 . https://doi.org/10.1016/S2213-2600(19)30367-4

Background: Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1β and IL-8 in bronchoalveolar lavage

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http://hdl.handle.net/10044/1/82700