Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Gert, Schaart"'
Autor:
Vera H. W. de Wit-Verheggen, Vera B. Schrauwen-Hinderling, Kim Brouwers, Johanna A. Jörgensen, Gert Schaart, Anne Gemmink, Emmani B. M. Nascimento, Matthijs K. C. Hesselink, Joachim E. Wildberger, Patrique Segers, David Montaigne, Bart Staels, Patrick Schrauwen, Lucas Lindeboom, Joris Hoeks, Tineke van de Weijer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-MRS) in vivo, is a prognostic factor in heart failure and is lowered in cardiometabolic disease. It has
Externí odkaz:
https://doaj.org/article/37b93e8a37d543e9a681f2a0a9782dad
Autor:
Sten M. M. van Beek, Yvonne M. H. Bruls, Froukje Vanweert, Ciarán E. Fealy, Niels J. Connell, Gert Schaart, Esther Moonen-Kornips, Johanna A. Jörgensen, Frédéric M. Vaz, Ellen T. H. C. Smeets, Peter J. Joris, Anne Gemmink, Riekelt H. Houtkooper, Matthijs K. C. Hesselink, Tore Bengtsson, Bas Havekes, Patrick Schrauwen, Joris Hoeks
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
β2-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents. Here the authors report that two-weeks of treatment with the β2-agonist clenbuterol improves insulin-stimulated glucose disposal in healthy
Externí odkaz:
https://doaj.org/article/c70a9895a6d34e0086372025f6878383
Autor:
Anne Gemmink, Sabine Daemen, Jakob Wefers, Jan Hansen, Dirk van Moorsel, Puji Astuti, Johanna A. Jorgensen, Esther Kornips, Gert Schaart, Joris Hoeks, Patrick Schrauwen, Matthijs K.C. Hesselink
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101727- (2023)
Objective: Mitochondrial network dynamics may play role in metabolic homeostasis. Whether mitochondrial network dynamics are involved in adaptations to day–night fluctuations in energy supply and demand is unclear. Here we visualized and quantified
Externí odkaz:
https://doaj.org/article/ec9b4e2549404d0f8c96da16498adf41
Autor:
Yvo J.M. op den Kamp, Anne Gemmink, Marlies de Ligt, Bas Dautzenberg, Esther Kornips, Johanna A. Jorgensen, Gert Schaart, Russell Esterline, Diego A. Pava, Joris Hoeks, Vera B. Schrauwen-Hinderling, Sander Kersten, Bas Havekes, Timothy R. Koves, Deborah M. Muoio, Matthijs K.C. Hesselink, Jan Oscarsson, Esther Phielix, Patrick Schrauwen
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101620- (2022)
Objective: SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on cardiovascular and renal outcomes; the underlying mechanism may be metabolic adaptations due to urinary glucose loss. Here, we investigated the cellular and
Externí odkaz:
https://doaj.org/article/ce94ee3f45bd45f3ad7d1120c2287583
Autor:
Carlijn M. E. Remie, Michiel P. B. Moonen, Kay H. M. Roumans, Emmani B. M. Nascimento, Anne Gemmink, Bas Havekes, Gert Schaart, Esther Kornips, Peter J. Joris, Vera B. Schrauwen-Hinderling, Joris Hoeks, Sander Kersten, Matthijs K. C. Hesselink, Esther Phielix, Wouter D. van Marken Lichtenbelt, Patrick Schrauwen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Cold acclimation has been shown to have beneficial metabolic effects, including improved insulin sensitivity in patients with type 2 diabetes. Here the authors show that a mild cold acclimation regiment during which overt shivering was prevented did
Externí odkaz:
https://doaj.org/article/1c9d9177ddf8413ba3d5b7a5b26199f5
Autor:
Yvonne MH Bruls, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, Joachim E Wildberger, Matthijs KC Hesselink, Deborah Muoio, Patrick Schrauwen, Vera B Schrauwen-Hinderling
Publikováno v:
EBioMedicine, Vol 49, Iss , Pp 318-330 (2019)
Background: Type 2 diabetes patients and individuals at risk of developing diabetes are characterized by metabolic inflexibility and disturbed glucose homeostasis. Low carnitine availability may contribute to metabolic inflexibility and impaired gluc
Externí odkaz:
https://doaj.org/article/bf98d20bc751497bae98af5243b845aa
Autor:
Sabine Daemen, Anne Gemmink, Bram Brouwers, Ruth C.R. Meex, Peter R. Huntjens, Gert Schaart, Esther Moonen-Kornips, Johanna Jörgensen, Joris Hoeks, Patrick Schrauwen, Matthijs K.C. Hesselink
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 71-81 (2018)
Objective: Intramyocellular lipid (IMCL) storage negatively associates with insulin resistance, albeit not in endurance-trained athletes. We investigated the putative contribution of lipid droplet (LD) morphology and subcellular localization to the s
Externí odkaz:
https://doaj.org/article/0123bf70ec134acd896cf9f7d55b97fa
Autor:
Nynke vanPolanen, Evelyn Zacharewicz, Marlies deLigt, Silvie Timmers, Esther Moonen‐Kornips, Gert Schaart, Joris Hoeks, Patrick Schrauwen, Matthijs K. C. Hesselink
Publikováno v:
Physiological Reports, Vol 9, Iss 2, Pp n/a-n/a (2021)
Abstract In non‐athletes, insulin sensitivity correlates negatively with intramyocellular lipid (IMCL) content. In athletes, however, a pattern of benign IMCL storage exists, which is characterized by lipid storage in type I muscle fibres, in small
Externí odkaz:
https://doaj.org/article/864421b3ff874f979b2f3e93901993ff
Autor:
Yvonne M H Bruls, Yvo J M Op den Kamp, Esther Phielix, Lucas Lindeboom, Bas Havekes, Gert Schaart, Esther Moonen-Kornips, Joachim E Wildberger, Matthijs K C Hesselink, Patrick Schrauwen, Vera B Schrauwen-Hinderling
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239506 (2020)
BackgroundLow carnitine status may underlie the development of insulin resistance and metabolic inflexibility. Intravenous lipid infusion elevates plasma free fatty acid (FFA) concentration and is a model for simulating insulin resistance and metabol
Externí odkaz:
https://doaj.org/article/3aa7b54fb6b249e0a6e6904ab28a4607
Autor:
Marlies de Ligt, Yvonne M.H. Bruls, Jan Hansen, Marie-Fleur Habets, Bas Havekes, Emmani B.M. Nascimento, Esther Moonen-Kornips, Gert Schaart, Vera B. Schrauwen-Hinderling, Wouter van Marken Lichtenbelt, Patrick Schrauwen
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 39-47 (2018)
Objective: Resveratrol supplementation improves metabolic health in healthy obese men, but not in patients with type 2 diabetes (T2D) when given as add-on therapy. Therefore, we examined whether resveratrol can enhance metabolic health in men at risk
Externí odkaz:
https://doaj.org/article/203bde5cf7464e55b156af7cd459255a