Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy

Autor: Song, Qiujing, Schmidt, Albrecht G., Hahn, Harvey S., Carr, Andrew N., Frank, Beate, Pater, Luke, Gerst, Mike, Young, Karen, Hoit, Brian D., McConnell, Bradley K., Haghighi, Kobra, Seidman, Christine E., Seidman, Jonathan G., Dorn, Gerald W., Kranias, Evangelia G.

Publikováno v: The Journal of clinical investigation. 111(6)

Cardiac hypertrophy, either compensated or decompensated, is associated with cardiomyocyte contractile dysfunction from depressed sarcoplasmic reticulum (SR) Ca(2+) cycling. Normalization of Ca(2+) cycling by ablation or inhibition of the SR inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654f3ef189184c92d3c677fd2d952d1e
https://pubmed.ncbi.nlm.nih.gov/12639985

Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure.

Autor: Schmidt AG; Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA., Zhai J, Carr AN, Gerst MJ, Lorenz JN, Pollesello P, Annila A, Hoit BD, Kranias EG

Publikováno v: Cardiovascular research [Cardiovasc Res] 2002 Nov; Vol. 56 (2), pp. 248-59.