KMT2A-MLLT1 and the Novel SEC16A-KMT2A in a Cryptic 3-Way Translocation t(9;11;19) Present in an Infant With Acute Lymphoblastic Leukemia

Autor: Roberto R.C. de Matos, Gerson M. Ferreira, Claus Meyer, Rolf Marschalek, Patrizia Larghero, Raul C. Ribeiro, Thomas Liehr, Moneeb Othman, Mariana T. de S.M. Bizarro, Elaine Sobral da Costa, Marcelo G.P. Land, Eliana Abdelhay, Renata Binato, Maria Luiza M. Silva

Publikováno v: Journal of Pediatric Hematology/Oncology. 44:e719-e722

About 25% of the patients with the translocation t(11;19)(q23;p13.3)/KMT2A-MLLT1 present three-way or more complex fusions, associated with a worse prognosis, suggesting that a particular mechanism creates functional KMT2A fusions for this condition.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de1adec00b72b2e1c327cdab168dce9
https://doi.org/10.1097/mph.0000000000002386

Twist1 Influences the Expression of Leading Members of the IL-17 Signaling Pathway in HER2-Positive Breast Cancer Cells

Autor: Bárbara Du Rocher, Eliana Abdelhay, Daniel Bulzico, Stephany Corrêa, Everton Cruz dos Santos, Luize G. Lima, Susanne Crocamo, Bruno R. B. Pires, Gerson M. Ferreira, Renata Binato

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12144, p 12144 (2021)

Breast cancer (BC) is a heterogeneous disease composed of multiple subtypes with different molecular characteristics and clinical outcomes. The metastatic process in BC depends on the transcription factors (TFs) related to epithelial-mesenchymal tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74ad2efa20ad70c0843517e1b91a034
https://pubmed.ncbi.nlm.nih.gov/34830027

Forkhead box M1 (FoxM1) gene is a new STAT3 transcriptional factor target and is essential for proliferation, survival and DNA repair of K562 cell line.

Autor: André L Mencalha, Renata Binato, Gerson M Ferreira, Barbara Du Rocher, Eliana Abdelhay

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e48160 (2012)

The forkhead box (Fox) M1 gene belongs to a superfamily of evolutionarily conserved transcriptional regulators that are involved in a wide range of biological processes, and its deregulation has been implicated in cancer survival, proliferation and c

Externí odkaz: https://doaj.org/article/b3c35d02fab445a190f3d51a590c2a09

Molecular approaches identify a cryptic MECOM rearrangement in a child with a rapidly progressive myeloid neoplasm

Autor: Gerson M. Ferreira, Elaine Sobral da Costa, Isabel M. Carreira, Marcelo Gerardin Poirot Land, Moneeb A.K. Othman, Joana B. Melo, Bruno Almeida Lopes, Maria Luiza Macedo Silva, Thomas Liehr, Mariana Tavares de Souza, Roberto R. Capela de Matos, Mariana Emerenciano, Raul C. Ribeiro

Publikováno v: Cancer Genetics. 221:25-30

Myeloid neoplasms are a heterogeneous group of hematologic disorders with divergent patterns of cell differentiation and proliferation, as well as divergent clinical courses. Rare recurrent genetic abnormalities related to this group of cancers are a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbe9e1d54926bb79121655dd9b46f86
https://doi.org/10.1016/j.cancergen.2017.12.002

A Novel TP53 Mutation Associated with TWIST1 and SIP1 Expression in an Aggressive Adrenocortical Carcinoma

Autor: Daniel Bulzico, Paulo Antônio Silvestre de Faria, Gerson M. Ferreira, Rocio Hassan, Davi Coe Torres, Leonardo Vieira Neto, Bruno R. B. Pires, Mario Vaisman, Eliana Abdelhay

Publikováno v: Endocrine Pathology. 28:326-331

Adrenocortical carcinomas (ACC) are very rare tumors related to TP53 mutations mostly in childhood onset cases. Epithelial-mesenchymal transition (EMT) transcription factors TWIST1 and Smad interacting protein 1 (SIP1) are related to poorer outcomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fd7cfe3d5702d761e5b7e13b9b518c
https://doi.org/10.1007/s12022-017-9482-7