Zobrazeno 1 - 10
of 1 947
pro vyhledávání: '"Gershwin ME"'
Autor:
Huang, W, Rainbow, DB, Wu, Y, Adams, D, Shivakumar, P, Kottyan, L, Karns, R, Aronow, B, Bezerra, J, Gershwin, ME, Peterson, LB, Wicker, LS, Ridgway, WM
Publikováno v:
Journal of Immunology. 200(1)
We previously reported that NOD.c3c4 mice develop spontaneous autoimmune biliary disease (ABD) with anti-mitochondrial Abs, histopathological lesions, and autoimmune T lymphocytes similar to human primary biliary cholangitis. In this article, we demo
Publikováno v:
Annual review of pathology. 13
Autoimmune hepatitis is an uncommon idiopathic syndrome of immune-mediated destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is incompletely understood but includes a clear association with human leukocyte ant
Autor:
Juran BD, Hirschfield GM, Invernizzi P, Atkinson EJ, Li Y, Xie G, Kosoy R, Ransom M, Sun Y, Bianchi I, Schlicht EM, Lleo A, Coltescu C, Bernuzzi F, Podda M, Lammert C, Shigeta R, Chan LL, Balschun T, Marconi M, Cusi D, Heathcote EJ, Mason AL, Myers RP, Milkiewicz P, Odin JA, Luketic VA, Bacon BR, Bodenheimer HC Jr, Liakina V, Vincent C, Levy C, Franke A, Gregersen PK, Bossa F, Gershwin ME, deAndrade M, Amos CI, Italian PBC Genetics Study Group, Lazaridis KN, Seldin MF, Siminovitch KA, Almasio PL, Alvaro D, Andriulli A, Barlassina C, Battezzati PM, Benedetti A, Bragazzi M, Brunetto M, Bruno S, Caliari L, Casella G, Civardi F, Coco B, Colli A, Colombo M, Colombo S, Cursaro C, Crocè LS, Crosignani A, Donato F, Fabris L, Ferrari C, Floreani A, Fontana R, Galli A, Grattagliano I, Lazzari R, Macaluso F, Malinverno F, Marra F, Marzioni M, Mascia E, Mattalia A, Montanari R, Morini L, Morisco F, Niro GA, Picciotto A, Portincasa P, Prati D, Rosina F, Rossi S, Selmi C, Spinzi G, Strazzabosco M, Tarallo S, Tiribelli C, Toniutto P, Vinci M, Zuin M., ANDREONE, PIETRO, MURATORI, LUIGI, MURATORI, PAOLO
Publikováno v:
Human Molecular Genetics; Vol 21
To further characterize the genetic basis of primary biliary cirrhosis (PBC), we genotyped 2426 PBC patients and 5731 unaffected controls from three independent cohorts using a single nucleotide polymorphism (SNP) array (Immunochip) enriched for auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286a70f36076f84418e4d94034d3b715
http://hdl.handle.net/11585/133623
http://hdl.handle.net/11585/133623
Autor:
Italian PBC Genetics Study Group, Seldin, Mf, Gershwin, Me, Podda, M, de Bakker PI, Cusi, D, Siminovitch, Ka, Gregersen, Pk, Amos, Ci, Bossa, F, Franke, A, Shigeta, R, Lleo, A, Kosoy, R, Raychaudhuri, S, Ransom, M, Invernizzi, P, Almasio, Pl, Alvaro, D, Andreone, P, Andriulli, A, Barlassina, C, Benedetti, A, Bernuzzi, F, Bianchi, I, Bragazzi, Mc, Brunetto, M, Bruno, S, Caliari, L, Casella, G, Civardi, F, Coco, B, Colli, A, Colombo, M, Colombo, S, Cursaro, C, Croce, Ls, Crosignani, A, Donato, F, Fabris, L, Ferrari, C, Floreani, A, Galli, A, Grattagliano, I, Lazzari, R, Macaluso, F, Marra, F, Marzioni, M, Mattalia, A, Montanari, R, Morini, L, Morisco, F, Moroni, L, Muratori, L, Muratori, P, Niro, G, Picciotto, A, Portincasa, P, Prati, D, Prisco, C, Rosina, F, Rossi, S, Selmi, C, Spinzi, G, Strazzabosco, M, Tarallo, S, Tiribelli, C, Toniutto, P, Vinci, M, Zuin, M.
Publikováno v:
Genes and immunity
Genes and Immunity; Vol 13
Genes and Immunity; Vol 13
Susceptibility to primary biliary cirrhosis (PBC) is strongly associated with human leukocyte antigen (HLA)-region polymorphisms. To determine if associations can be explained by classical HLA determinants, we studied Italian, 676 cases and 1440 cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f45b1e10072c24202dd413e2604f5e7
http://hdl.handle.net/11368/2656515
http://hdl.handle.net/11368/2656515
Autor:
Invernizzi, P, Selmi, C, Poli, F, Frison, S, Floreani, A, Alvaro, D, Almasio, P, Rosina, F, Marzioni, M, Fabris, L, Muratori, L, Qi, L, Seldin, Mf, Gershwin, Me, Podda, M, Andreoletti, M, Andriulli, A, Baldini, V, Battezzati, Pm, Benedetti, A, Bernuzzi, F, Bianchi, Fb, Bianchi, I, Bignotto, M, Bragazzi, Mc, Brunetto, M, Caimi, M, Caliari, L, Caporaso, N, Casella, G, Casiraghi, A, Colli, A, Colombo, M, Conte, D, Croce, L, Crosignani, A, Dottorini, L, Ferrari, C, Fraquelli, M, Frati, Ce, Galli, A, Lleo, A, Mancino, Mg, Mandelli, G, Marra, F, Montanari, R, Monti, V, Morini, L, Morisco, F, Niro, G, Palasciano, G, Calmieri, Vo, Pasini, S, Picciotto, A, Portincasa, P, Pozzoli, V, Spinzi, G, Strazzabosco, M, Tiribelli, C, Toniutto, Pierluigi, Zerminai, P, Zuin, M.
Genetic factors are critical in determining susceptibility to primary biliary cirrhosis (PBC), but there has not been a clear association with human leukocyte antigen (HLA) genes. We performed a multicenter case-control study and analyzed HLA class I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cd137b02a393de0077991ebe7c319d
http://hdl.handle.net/11390/858961
http://hdl.handle.net/11390/858961
Autor:
van Leeuwen, Marcella, Damoiseaux, Jan, Duijvestijn, Adriaan, Heeringa, Peter, Gijbels, Marion, de Winther, Menno, Tervaert, Jan Willem Cohen, Shoenfeld, Y, Gershwin, ME
Publikováno v:
Annals of the New York Academy of Sciences, 1173, 274-279. Wiley-Blackwell
CONTEMPORARY CHALLENGES IN AUTOIMMUNITY, 274-279
STARTPAGE=274;ENDPAGE=279;TITLE=CONTEMPORARY CHALLENGES IN AUTOIMMUNITY
CONTEMPORARY CHALLENGES IN AUTOIMMUNITY, 274-279
STARTPAGE=274;ENDPAGE=279;TITLE=CONTEMPORARY CHALLENGES IN AUTOIMMUNITY
Introduction: It is hypothesized that IgM antibodies to oxidized LDL are anti-atherogenic. Myeloperoxidase from plaque-infiltrating neutrophils catalyzes the production of hypochlorite (HOCl), which oxidizes LDL. Here we study the IgM response to HOC
Autor:
Damoiseaux, Jan, Tervaert, Jan Willem Cohen, Derksen, Ronald, Hamann, Dorte, Hooijkaas, Herbert, Klasen, Ina, Kallenberg, Cees, Limburg, Pieter, Smeenk, Ruud, Shoenfeld, Y, Gershwin, ME
Publikováno v:
Annals of the New York Academy of Sciences, 1173, 10-14. Wiley-Blackwell
Contemporary challenges in autoimmunity, 10-14
STARTPAGE=10;ENDPAGE=14;TITLE=Contemporary challenges in autoimmunity
Contemporary challenges in autoimmunity, 10-14
STARTPAGE=10;ENDPAGE=14;TITLE=Contemporary challenges in autoimmunity
Several initiatives have been undertaken, independent of the European Autoantibody Standardization Initiative (EASI), to standardize autoantibodies in the Netherlands. The Dutch EASI team has made an inventory of which initiatives on autoantibody sta
Autor:
Cordell, HJ, Han, Y, Mells, GF, Li, Y, Hirschfield, GM, Greene, CS, Xie, G, Juran, BD, Zhu, D, Qian, DC, Floyd, JAB, Morley, KI, Prati, D, Lleo, A, Cusi, D, Gershwin, ME, Anderson, CA, Lazaridis, KN, Invernizzi, P, Seldin, MF, Sandford, RN, Amos, CI, Siminovitch, KA, Schlicht, EM, Lammert, C, Atkinson, EJ, Chan, LL, De Andrade, M, Balschun, T, Mason, AL, Myers, RP, Zhang, J, Milkiewicz, P, Qu, J, Odin, JA, Luketic, VA, Bacon, BR, Bodenheimer, HC, Liakina, V, Vincent, C, Levy, C, Gregersen, PK, Almasio, PL, Alvaro, D, Andreone, P, Andriulli, A, Barlassina, C, Battezzati, PM, Benedetti, A, Bernuzzi, F, Bianchi, I, Bragazzi, MC, Brunetto, M, Bruno, S, Casella, G, Coco, B, Colli, A, Colombo, M, Colombo, S, Cursaro, C, Crocè, LS, Crosignani, A, Donato, MF, Elia, G, Fabris, L, Ferrari, C, Floreani, A, Foglieni, B, Fontana, R, Galli, A, Lazzari, R, Macaluso, F, Malinverno, F, Marra, F, Marzioni, M, Mattalia, A, Montanari, R, Morini, L, Morisco, F, Mousa Hani, S, Muratori, L, Muratori, P, Niro, GA, Palmieri, VO, Picciotto, A, Podda, M, Portincasa, P, Ronca, V, Rosina, F, Rossi, S, Sogno, I, Spinzi, G, Spreafico, M
© 2015 Macmillan Publishers Limited. All rights reserved.Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::c707b41993c0ef059c9d7e88f5f038d5
http://hdl.handle.net/10044/1/32625
http://hdl.handle.net/10044/1/32625
Autor:
Kar, Sp, Seldin, Mf, Chen, W, Lu, E, Hirschfield, Gm, Invernizzi, P, Heathcote, J, Cusi, D, Almasio, Pl, Alvaro, D, Andreone, P, Andriulli, A, Barlassina, C, Benedetti, A, Bernuzzi, F, Bianchi, I, Bragazzi, M, Brunetto, M, Bruno, S, Caliari, L, Casella, G, Coco, B, Colli, A, Colombo, M, Colombo, S, Cursaro, C, Croce, Ls, Crosignani, A, Donato, F, Elia, G, Fabris, L, Floreani, A, Galli, A, Grattagliano, I, Lazzari, R, Lleo, A, Macaluso, F, Marra, F, Marzioni, M, Mascia, E, Mattalia, A, Montanari, R, Morini, L, Morisco, F, Muratori, L, Muratori, P, Niro, G, Picciotto, A, Podda, M, Portincasa, P, Prati, D, Raggi, C, Rosina, F, Rossi, S, Sogno, I, Spinzi, G, Strazzabosco, M, Tarallo, Sonia, Tarocchi, M, Tiribelli, C, Toniutto, P, Vinci, M, Zuin, M, Gershwin, Me, Siminovitch, Ka, Amos, Ci, Tarallo, S, Zuin, M.
Genome-wide association studies (GWAS) have successfully identified several loci associated with primary biliary cirrhosis (PBC) risk. Pathway analysis complements conventional GWAS analysis. We applied the recently developed linear combination test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d005b88683a1587aac38a2f8c4e92977
https://hdl.handle.net/11368/2656513
https://hdl.handle.net/11368/2656513
Autor:
De Leeuw, K., Kallenberg, Cees, Bijl, Marc, Shoenfeld, Y., Gershwin, M.E., Shoenfeld, Y, Gershwin, ME
Publikováno v:
Autoimmune diseases and treatment : organ-specific and systemic disorders, 362-371
STARTPAGE=362;ENDPAGE=371;TITLE=Autoimmune diseases and treatment : organ-specific and systemic disorders
STARTPAGE=362;ENDPAGE=371;TITLE=Autoimmune diseases and treatment : organ-specific and systemic disorders
Systemic autoimmune diseases such as systemic lupus erythematosus and Wegener's granulomatosis are associated with a significantly increased prevalence of cardiovascular disease (CVD) compared with age- and sex-matched controls. Many risk factors are