Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Gersende Alphonse"'
Autor:
Anne-Sophie Wozny, Gersende Alphonse, Audrey Cassard, Céline Malésys, Safa Louati, Michael Beuve, Philippe Lalle, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract DNA double-strand breaks (DSBs) induced by photon irradiation are the most deleterious damage for cancer cells and their efficient repair may contribute to radioresistance, particularly in hypoxic conditions. Carbon ions (C-ions) act indepen
Externí odkaz:
https://doaj.org/article/b9246a0bfb4742b4a947afac465121a4
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 12, Iss , Pp 17-21 (2019)
The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV
Externí odkaz:
https://doaj.org/article/feb660222ca044bb8779f88dc904f277
Autor:
Arnaud Gauthier, Pierre Philouze, Alexandra Lauret, Gersende Alphonse, Céline Malesys, Dominique Ardail, Léa Payen, Philippe Céruse, Anne-Sophie Wozny, Claire Rodriguez-Lafrasse
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 3, p 445 (2022)
Patients with locally advanced oropharyngeal carcinoma treated with neoadjuvant chemotherapy are reassessed both radiologically and clinically to adapt their treatment after the first cycle. However, some responders show early tumor progression after
Externí odkaz:
https://doaj.org/article/7fb644a5e9534d5fb0738f5539dd3423
Autor:
Pierre Philouze, Arnaud Gauthier, Alexandra Lauret, Céline Malesys, Giovanna Muggiolu, Sylvie Sauvaigo, Antoine Galmiche, Philippe Ceruse, Gersende Alphonse, Anne-Sophie Wozny, Claire Rodriguez-Lafrasse
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 877 (2022)
Squamous cell carcinoma is the most common type of head and neck cancer (HNSCC) with a disease-free survival at 3 years that does not exceed 30%. Biomarkers able to predict clinical outcomes are clearly needed. The purpose of this study was to invest
Externí odkaz:
https://doaj.org/article/75246cbeed00412095b89786d517030b
Autor:
Anne-Sophie Wozny, Arnaud Gauthier, Gersende Alphonse, Céline Malésys, Virginie Varoclier, Michael Beuve, Delphine Brichart-Vernos, Nicolas Magné, Nicolas Vial, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Publikováno v:
Cancers, Vol 13, Iss 15, p 3833 (2021)
Hypoxia-Inducible Factor 1α (HIF-1α), which promotes cancer cell survival, is the main regulator of oxygen homeostasis. Hypoxia combined with photon and carbon ion irradiation (C-ions) stabilizes HIF-1α. Silencing HIF-1α under hypoxia leads to su
Externí odkaz:
https://doaj.org/article/8ca5e27fc78d4a77b39ddc35942c2c7d
Dual 'mAb' HER family blockade in head and neck cancer human cell lines combined with photon therapy
Autor:
Jean-Baptiste Guy, Benoîte Méry, Edouard Ollier, Sophie Espenel, Alexis Vallard, Anne-Sophie Wozny, Stéphanie Simonet, Alexandra Lauret, Priscillia Battiston-Montagne, Dominique Ardail, Gersende Alphonse, Chloé Rancoule, Claire Rodriguez-Lafrasse, Nicolas Magné
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Head and neck cancer stem cells (CSCs) are highly resistant to treatment. When EGFR is overexpressed in head and neck squamous cell carcinoma (HNSCC), HER2 and HER3 are also expressed. The aim of the present study was to investigate the effe
Externí odkaz:
https://doaj.org/article/25541696948a416d88c4361dcc1a3747
Autor:
Riad Ladjohounlou, Safa Louati, Alexandra Lauret, Arnaud Gauthier, Dominique Ardail, Nicolas Magne, Gersende Alphonse, Claire Rodriguez-Lafrasse
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7200 (2020)
We investigated the potential involvement of ceramide-enriched membrane domains in radiation-induced targeted and nontargeted effects using head and neck squamous cell carcinoma with opposite radiosensitivities. In radiosensitive SCC61 cells, the pro
Externí odkaz:
https://doaj.org/article/917626871d40469fbece9ce51b38db21
Autor:
Anne-Sophie Wozny, Guillaume Vares, Gersende Alphonse, Alexandra Lauret, Caterina Monini, Nicolas Magné, Charlotte Cuerq, Akira Fujimori, Jean-Claude Monboisse, Michael Beuve, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Publikováno v:
Cancers, Vol 11, Iss 4, p 468 (2019)
Although conventional radiotherapy promotes the migration/invasion of cancer stem cells (CSCs) under normoxia, carbon ion (C-ion) irradiation actually decreases these processes. Unraveling the mechanisms of this discrepancy, particularly under the hy
Externí odkaz:
https://doaj.org/article/186deb7eace64147ad805372bbea07e2
Autor:
Nicolas Vial, Sophie Espenel, Claire Rodriguez-Lafrasse, Anne-Sophie Wozny, Dominique Ardail, Nicolas Magné, M.-A. Garcia, Safa Louati, Arnaud Gauthier, Gersende Alphonse, Jean-Baptiste Guy, Céline Malésys
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology, Springer Verlag, 2021, 147 (7), pp.1905-1916. ⟨10.1007/s00432-021-03593-8⟩
Journal of Cancer Research and Clinical Oncology, Springer Verlag, 2021, 147 (7), pp.1905-1916. ⟨10.1007/s00432-021-03593-8⟩
International audience; PurposeThe clinical outcome of head and neck squamous cell carcinoma (HNSCC) remains poor, partly due to the presence of resistant cancer stem cells (CSCs) which are responsible of recurrences. CSCs have low EGFR expression an
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 12, Iss, Pp 17-21 (2019)
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩
Highlights • The accuracy of biophysical modeling is crucial for particle therapy. • Comparison of LEM(I-IV), MKM and NanOx models with data for 3 cell lines. • χ2 scoring for α(LET) curves. • NanOx yields the highest score more often than