Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation

Autor: Kathleen Santamaria, Fabienne Desmots, Simon Leonard, Gersende Caron, Marion Haas, Céline Delaloy, Fabrice Chatonnet, Delphine Rossille, Amandine Pignarre, Céline Monvoisin, Marine Seffals, Claire Lamaison, Michel Cogné, Karin Tarte, Thierry Fest

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

B cell affinity maturation occurs in the germinal center (GC). Light-zone (LZ) GC B cells (BGC-cells) interact with follicular dendritic cells (FDCs) and compete for the limited, sequential help from T follicular helper cells needed to escape from ap

Externí odkaz: https://doaj.org/article/2a37c82726ad4a66bf158171a125e426

The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation

Autor: Fabrice Chatonnet, Amandine Pignarre, Aurélien A. Sérandour, Gersende Caron, Stéphane Avner, Nicolas Robert, Alboukadel Kassambara, Audrey Laurent, Maud Bizot, Xabier Agirre, Felipe Prosper, José I. Martin-Subero, Jérôme Moreaux, Thierry Fest, Gilles Salbert

Publikováno v: Haematologica, Vol 105, Iss 3 (2020)

Cell identity relies on the cross-talk between genetics and epigenetics and their impact on gene expression. Oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) is the first step of an active DNA demethylation process occurring ma

Externí odkaz: https://doaj.org/article/3f5c35394af14794af1956e6002ceedc

Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues.

Autor: Iman Dalloul, François Boyer, Zeinab Dalloul, Amandine Pignarre, Gersende Caron, Thierry Fest, Fabrice Chatonnet, Céline Delaloy, Anne Durandy, Robin Jeannet, Emilie Lereclus, Hend Boutouil, Jean-Claude Aldigier, Sophie Péron, Sandrine Le Noir, Jeanne Cook-Moreau, Michel Cogné

Publikováno v: PLoS Genetics, Vol 15, Iss 6, p e1007721 (2019)

B-cell activation yields abundant cell death in parallel to clonal amplification and remodeling of immunoglobulin (Ig) genes by activation-induced deaminase (AID). AID promotes affinity maturation of Ig variable regions and class switch recombination

Externí odkaz: https://doaj.org/article/b008f55c724e43988bbb8e81994f41ac

Supplementary Data from Pan-HDAC Inhibitors Restore PRDM1 Response to IL21 in CREBBP-Mutated Follicular Lymphoma

Autor: Thierry Fest, Vincent Ribrag, Karin Tarte, Fabrice Jardin, Thierry Lamy, Pascal Godmer, Marc-Antoine Belaud-Rotureau, Catherine Henry, Gersende Caron, Valérie Camara-Clayette, Jérôme Le Priol, Eric Guiheneuf, Cédric Pastoret, Francisco Llamas-Gutierrez, Céline Pangault, Mikaël Roussel, Fabienne Desmots

Figure S1 : (A) The 1769-genes signature corresponding to CB/CC transition and CB response to IL-21/CD40L co-stimulation and that are differentially expressed in FL compared to CC and CB were explored using Ingenuity Pathway Analysis (IPA). IPA enric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6ac642ed71a057543286c71e80cba0
https://doi.org/10.1158/1078-0432.22474250.v1

Plasmablasts derive from CD23– activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction

Autor: Fabienne Desmots, Thierry Fest, Gersende Caron, Amandine Pignarre, Fabrice Chatonnet, Marion Haas

Publikováno v: Blood
Blood, 2021, 137 (9), pp.1166-1180. ⟨10.1182/blood.2020005083⟩
Blood, American Society of Hematology, 2021, 137 (9), pp.1166-1180. ⟨10.1182/blood.2020005083⟩

The terminal differentiation of B cells into antibody-secreting cells (ASCs) is a critical component of adaptive immune responses. However, it is a very sensitive process, and dysfunctions lead to a variety of lymphoproliferative neoplasias including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3641055a536fd644d0c7a31d50454d
https://doi.org/10.1182/blood.2020005083