Výsledky vyhledávání - "Gersende, ALPHONSE"

Akademický článek

Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells

Autor: Anne-Sophie Wozny, Gersende Alphonse, Audrey Cassard, Céline Malésys, Safa Louati, Michael Beuve, Philippe Lalle, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)

Abstract DNA double-strand breaks (DSBs) induced by photon irradiation are the most deleterious damage for cancer cells and their efficient repair may contribute to radioresistance, particularly in hypoxic conditions. Carbon ions (C-ions) act indepen

Externí odkaz: https://doaj.org/article/b9246a0bfb4742b4a947afac465121a4

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Akademický článek

Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions

Autor: Caterina Monini, Gersende Alphonse, Claire Rodriguez-Lafrasse, Étienne Testa, Michaël Beuve

Publikováno v: Physics and Imaging in Radiation Oncology, Vol 12, Iss , Pp 17-21 (2019)

The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV

Externí odkaz: https://doaj.org/article/feb660222ca044bb8779f88dc904f277

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Akademický článek

Dual 'mAb' HER family blockade in head and neck cancer human cell lines combined with photon therapy

Autor: Jean-Baptiste Guy, Benoîte Méry, Edouard Ollier, Sophie Espenel, Alexis Vallard, Anne-Sophie Wozny, Stéphanie Simonet, Alexandra Lauret, Priscillia Battiston-Montagne, Dominique Ardail, Gersende Alphonse, Chloé Rancoule, Claire Rodriguez-Lafrasse, Nicolas Magné

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Head and neck cancer stem cells (CSCs) are highly resistant to treatment. When EGFR is overexpressed in head and neck squamous cell carcinoma (HNSCC), HER2 and HER3 are also expressed. The aim of the present study was to investigate the effe

Externí odkaz: https://doaj.org/article/25541696948a416d88c4361dcc1a3747

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Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma

Autor: Nicolas Vial, Sophie Espenel, Claire Rodriguez-Lafrasse, Anne-Sophie Wozny, Dominique Ardail, Nicolas Magné, M.-A. Garcia, Safa Louati, Arnaud Gauthier, Gersende Alphonse, Jean-Baptiste Guy, Céline Malésys

Publikováno v: Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology, Springer Verlag, 2021, 147 (7), pp.1905-1916. ⟨10.1007/s00432-021-03593-8⟩

International audience; PurposeThe clinical outcome of head and neck squamous cell carcinoma (HNSCC) remains poor, partly due to the presence of resistant cancer stem cells (CSCs) which are responsible of recurrences. CSCs have low EGFR expression an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9729b50e7981ba5c11d16531b65c3d
https://doi.org/10.1007/s00432-021-03593-8

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CD44, γ-H2AX, and p-ATM Expressions in Short-Term Ex Vivo Culture of Tumour Slices Predict the Treatment Response in Patients with Oral Squamous Cell Carcinoma

Autor: Pierre Philouze, Arnaud Gauthier, Alexandra Lauret, Céline Malesys, Giovanna Muggiolu, Sylvie Sauvaigo, Antoine Galmiche, Philippe Ceruse, Gersende Alphonse, Anne-Sophie Wozny, Claire Rodriguez-Lafrasse

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 877, p 877 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 877

Squamous cell carcinoma is the most common type of head and neck cancer (HNSCC) with a disease-free survival at 3 years that does not exceed 30%. Biomarkers able to predict clinical outcomes are clearly needed. The purpose of this study was to invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b7d3a9cedc2a02e81598a927caf803
http://europepmc.org/articles/PMC8775909

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Involvement of HIF-1α in the Detection, Signaling, and Repair of DNA Double-Strand Breaks after Photon and Carbon-Ion Irradiation

Autor: Anne-Sophie, Wozny, Arnaud, Gauthier, Gersende, Alphonse, Céline, Malésys, Virginie, Varoclier, Michael, Beuve, Delphine, Brichart-Vernos, Nicolas, Magné, Nicolas, Vial, Dominique, Ardail, Tetsuo, Nakajima, Claire, Rodriguez-Lafrasse

Publikováno v: Cancers
Cancers, MDPI, 2021, 13 (15), pp.3833. ⟨10.3390/cancers13153833⟩
Cancers, Vol 13, Iss 3833, p 3833 (2021)
Volume 13
Issue 15

Simple Summary Hypoxia-Inducible Factor 1α (HIF-1α), the main regulator of the oxygen homeostasis, promotes cancer cell survival through proliferation, angiogenesis, metastasis and radioresistance. Previously, our group demonstrated that silencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::564d3e24a0a55e6e076ba29f1988467a
https://hal.archives-ouvertes.fr/hal-03326508

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Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions

Autor: Etienne Testa, Gersende Alphonse, Claire Rodriguez-Lafrasse, Caterina Monini, Michael Beuve

Publikováno v: Physics and Imaging in Radiation Oncology, Vol 12, Iss, Pp 17-21 (2019)
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩

Highlights • The accuracy of biophysical modeling is crucial for particle therapy. • Comparison of LEM(I-IV), MKM and NanOx models with data for 3 cell lines. • χ2 scoring for α(LET) curves. • NanOx yields the highest score more often than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e63cb9a2166d10c72c0e5cc748e3a2
https://doi.org/10.1016/j.phro.2019.10.004

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Abstract 3493: Comprehensive analysis of the DNA repair enzyme signature in tumor and blood cells from head and neck cancer patients and correlation with clinical data from a 18-months follow-up study

Autor: Sylvie Sauvaigo, Giovanna Muggiolu, Sarah Libert, Bertrand Treillard, Gersende Alphonse, Christian A. Righini, Philippe Ceruse, Pierre Philouze, Claire Rodriguez-Lafrasse

Publikováno v: Cancer Research. 82:3493-3493

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide. It is often associated with a history of smoking/alcohol consumption or exposure to the human papilloma virus (HPV). Beyond surgery, treatment usually includes DNA d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a03b173568144d56d732fd4fcc636fe
https://doi.org/10.1158/1538-7445.am2022-3493

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Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells

Autor: Safa Louati, Claire Rodriguez-Lafrasse, Arnaud Gauthier, Riad Ladjohounlou, Nicolas Magné, Gersende Alphonse, Alexandra Lauret, Dominique Ardail

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.7200. ⟨10.3390/ijms21197200⟩
International Journal of Molecular Sciences, Vol 21, Iss 7200, p 7200 (2020)
Volume 21
Issue 19

Background: It is now established that radiation can affect membranes of mammalian cells in several ways. Depending on the degree of conditioning and mobility of phospholipidic molecules within the plasma membrane, cells exhibit different degrees of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bb59ba560ad6cfcdd4c8867db47a0b
https://hal.archives-ouvertes.fr/hal-03001763

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