Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gerry Steele"'
Publikováno v:
Chemical Engineering Research and Design. 164:400-411
A case study highlighting the risk of generating undesired hydrate polymorph following seeded distillative crystallization of an active pharmaceutical ingredient (API) from aqueous alcoholic solution and a strategy to overcome the issue is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0085333484017e41c8685a9bf863a7de
https://doi.org/10.1016/j.cherd.2020.09.021
https://doi.org/10.1016/j.cherd.2020.09.021
Autor:
Gerry Steele
Publikováno v:
Pharmaceutical Quality by Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5eaa833fe6ed1e606d68a09eeb11efd
https://doi.org/10.1002/9781118895238.ch4
https://doi.org/10.1002/9781118895238.ch4
Autor:
Martin Kuentz, Osmo Antikainen, Olivier Steiger, Daniele Angelosante, Moritz von Stosch, Srinivas Tummala, Min-Sen Chiu, John Oreilly, Miklos Lenner, Herman J. M. Kramer, Krist V. Gernaey, Hajnalka Pataki, Huiquan Wu, Niklas Sandler, Francois Kjell, Gerry Steele, Tom Leyssens, Brian Glennon, Remko Westra, Patrick Frohberg, Kaoutar Abbou-Oucherif, Konrad Hungerbühler, Richard D. Braatz, James D. Litster, Vamsi Krishna Kamaraju, Alfons Baiker, Rui Oliveira, Reginald B. H. Tan, Zoltan K. Nagy, Rafiqul Gani, Julian Morris, Mansoor A. Khan, Detlef Pape, Zeng-Ping Chen, Emmanuel Delle-Case, Des O'grady, Marjatta Louhi-Kultanen, Ravendra Singh, James W. Rydzak, Jouko Yliruusi, Levente L. Simon, Yannick Maret, Fabian Meemken, Anjan Pandey, Joachim Ulrich, György Marosi
Publikováno v:
Organic Process Research & Development. 19:3-62
This multiauthor review article aims to bring readers up to date with some of the current trends in the field of process analytical technology (PAT) by summarizing each aspect of the subject (sensor development, PAT based process monitoring and contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3e3fe4052f622e8a932cc658cd5900
https://doi.org/10.1021/op500261y
https://doi.org/10.1021/op500261y
Autor:
Talbir Austin, Gerry Steele
Publikováno v:
Pharmaceutical Preformulation and Formulation ISBN: 9780429147654
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4dd4d48e50c3ab279e0f3945e4770a1
https://doi.org/10.3109/9781420073188-6
https://doi.org/10.3109/9781420073188-6
Publikováno v:
Organic Process Research & Development. 13:1357-1363
In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09df3ca981abbfaee6ae522fa1738e21
https://doi.org/10.1021/op900237x
https://doi.org/10.1021/op900237x
Autor:
Krystel S. Howard, Basu Saha, David J. Martin, Anne L. Robertson, Zoltan K. Nagy, Gerry Steele
Publikováno v:
Crystal Growth & Design. 9:3964-3975
Manufacturing of medicines often requires a crystallization stage. The crystallization method must be designed to produce the desired crystal form with specific shape, size distribution, and polymorphic form. This paper presents the use of process an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::661f8fd8b63e58f1acd07751eb70b0fc
https://doi.org/10.1021/cg900108e
https://doi.org/10.1021/cg900108e
Publikováno v:
Organic Process Research & Development. 13:590-597
This paper presents the application of process analytical technology (PAT) tools in combination with solid state analytical (SSA) techniques for the detection of solvent-mediated pseudopolymorphic ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae5d7b57c628347292e9b67b803fc9e
https://doi.org/10.1021/op800309f
https://doi.org/10.1021/op800309f
Publikováno v:
IFAC Proceedings Volumes. 40:131-136
The paper presents a comprehensive evaluation study into the use of process analytical technology (PAT) for the in situ detection and monitoring of the polymorphic transformations from anhydrous to hydrate form, of a model system, caffeine in water.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d371d8416246bd933886cd55c9d86c
https://doi.org/10.3182/20070606-3-mx-2915.00140
https://doi.org/10.3182/20070606-3-mx-2915.00140
Controlling polymorphism is one of the most difficult challenges for the pharmaceutical industry. Polymorphs of the same compound can have very different properties that might affect the quality of the final drug. Many studies have focused on trying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813e86ac8c4daf844df31dbc16fa943e
http://hdl.handle.net/11583/2933998
http://hdl.handle.net/11583/2933998
Autor:
Emilie Deneau, Gerry Steele
Publikováno v:
Organic Process Research & Development. 9:943-950
The oiling out and crystallization of a pharmaceutical compound from a water−ethanol mixture has been studied using a range of in-line process analytical techniques in order to more fully understand the phenomenon and build in control of its crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::254dcc00629f7bb85074392cf5724291
https://doi.org/10.1021/op050107c
https://doi.org/10.1021/op050107c