Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Gerry A. F. Nicolaes"'
Autor:
Sara Bülow Anderberg, Joram Huckriede, Michael Hultström, Anders Larsson, Femke de Vries, Miklos Lipcsey, Gerry A. F. Nicolaes, Robert Frithiof
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Background Acute kidney injury (AKI) is common in critical cases of coronavirus disease 2019 (COVID-19) and associated with worse outcome. Dysregulated neutrophil extracellular trap (NET) formation is one of several suggested pathophysiologi
Externí odkaz:
https://doaj.org/article/e38a5599bce141d7baaa95ecdb09607b
Autor:
Tom Arfman, Valentina Zollet, Nick vanEs, Floris T. M. Bosch, Gerry A. F. Nicolaes, Nicoletta Sorvillo, Jan Voorberg
Publikováno v:
eJHaem, Vol 5, Iss 1, Pp 136-140 (2024)
Abstract Neutrophil released peptidyl arginine deiminase 4 (PAD4) converts arginine residues on plasma proteins into citrulline. Here, we developed an assay to quantify citrullinated fibrinogen. We employed a biotin‐conjugated phenylglyoxal (biotin
Externí odkaz:
https://doaj.org/article/81af964bf12e4c81afc00468102d5cf6
Autor:
Anjana Singh, Adriaan O. Kraaijeveld, Adelina Curaj, Kanin Wichapong, Linda Hammerich, Saskia C. A. de Jager, Ilze Bot, Sergei P. Atamas, Theo J. C. van Berkel, J. Wouter Jukema, Iain Comerford, Shaun R. McColl, Barend Mees, Johan W. M. Heemskerk, Gerry A. F. Nicolaes, Tilman Hackeng, Elisa Anamaria Liehn, Frank Tacke, Erik A. L. Biessen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigation into the r
Externí odkaz:
https://doaj.org/article/573017efcc53412a84624e171b71058e
Autor:
Berke Gürkan, Hessel Poelman, Liza Pereverzeva, Danielle Kruijswijk, Alex F. de Vos, Anouk G. Groenen, Edgar E. Nollet, Kanin Wichapong, Esther Lutgens, Tom van der Poll, Jiangfeng Du, W. Joost Wiersinga, Gerry A. F. Nicolaes, Cornelis van ‘t Veer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 depend
Externí odkaz:
https://doaj.org/article/0c33abacff5a46efbd205dff44b03560
Autor:
Chris P. M. Reutelingsperger, Marion J. Gijbels, Henri Spronk, Rene Van Oerle, Roy Schrijver, Peter Ekhart, Sjef de Kimpe, Gerry A. F. Nicolaes
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1376 (2024)
Extracellular histones have been shown to act as DAMPs in a variety of inflammatory diseases. Moreover, they have the ability to induce cell death. In this study, we show that M6229, a low-anticoagulant fraction of unfractionated heparin (UFH), rescu
Externí odkaz:
https://doaj.org/article/d619560b95fb4294b9ca9688d8e839f3
Autor:
Anna L. Beukenhorst, Jacopo Frallicciardi, Clarissa M. Koch, Jaco M. Klap, Angela Phillips, Michael M. Desai, Kanin Wichapong, Gerry A. F. Nicolaes, Wouter Koudstaal, Galit Alter, Jaap Goudsmit
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
Externí odkaz:
https://doaj.org/article/9503b87ece3445a8a8e5186347752be5
Autor:
Anna L. Beukenhorst, Jacopo Frallicciardi, Clarissa M. Koch, Jaco M. Klap, Angela Phillips, Michael M. Desai, Kanin Wichapong, Gerry A. F. Nicolaes, Wouter Koudstaal, Galit Alter, Jaap Goudsmit
Publikováno v:
Frontiers in Virology, Vol 2 (2022)
Human monoclonal antibodies (hmAbs) that protect against all influenza A and B strains are considered the road to universal influenza vaccines. Based on publicly-available data, we analyze the mechanistic and structural basis of pan-influenza protect
Externí odkaz:
https://doaj.org/article/7caffad1dc504f2b98bbea4798b7eb24
Autor:
Joram Huckriede, Sara Bülow Anderberg, Albert Morales, Femke de Vries, Michael Hultström, Anders Bergqvist, José T. Ortiz-Pérez, Jan Willem Sels, Kanin Wichapong, Miklos Lipcsey, Marcel van de Poll, Anders Larsson, Tomas Luther, Chris Reutelingsperger, Pablo Garcia de Frutos, Robert Frithiof, Gerry A. F. Nicolaes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Coronavirus disease 19 (COVID-19) presents with disease severities of varying degree. In its most severe form, infection may lead to respiratory failure and multi-organ dysfunction. Here we study the levels and evolution of the damage associ
Externí odkaz:
https://doaj.org/article/42f33b11eed544279e2c99d11b536402
Autor:
Angelina Pavlic, Hessel Poelman, Grzegorz Wasilewski, Kanin Wichapong, Petra Lux, Cecile Maassen, Esther Lutgens, Leon J. Schurgers, Chris P. Reutelingsperger, Gerry A. F. Nicolaes
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2027 (2023)
Vascular calcification (VC) is an important contributor and prognostic factor in the pathogenesis of cardiovascular diseases. VC is an active process mediated by the release of extracellular vesicles by vascular smooth muscle cells (VSMCs), and the e
Externí odkaz:
https://doaj.org/article/13c3fae4fd2a4699ac409f003b14fc17
Autor:
Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Caiment, Jiri Aubrecht, Gerry A. F. Nicolaes, Jos C. S. Kleinjans, Jacco J. Briedé
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 6, Pp 609-616 (2019)
Four complementary approaches were used to investigate acetaminophen overdose as a risk factor for Parkinson's disease (PD). Circulating microRNAs (miRNAs) serum profiles from acetaminophen‐overdosed patients were compared with patients with termin
Externí odkaz:
https://doaj.org/article/c4299ed8807e4bb1b34aa2f0ebac37f4